GTSE1 (G2 and S-phase expressed 1)

Gene

• Entrez ID: 51512
• Gene name: G2 and S-phase expressed 1
• Gene symbol: GTSE1
• Synonyms: B99
• Chromosome: 22
• Chromosome location: 22q13.31
• Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor supp

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042290	hsa-miR-484	CLASH	23622248
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT613532	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT1038269	hsa-miR-122	CLIP-seq
MIRT1038270	hsa-miR-1224-3p	CLIP-seq
MIRT1038271	hsa-miR-1245b-5p	CLIP-seq
MIRT1038272	hsa-miR-1262	CLIP-seq
MIRT1038273	hsa-miR-1293	CLIP-seq
MIRT1038274	hsa-miR-1297	CLIP-seq
MIRT1038275	hsa-miR-150	CLIP-seq
MIRT1038276	hsa-miR-151-5p	CLIP-seq
MIRT1038277	hsa-miR-151b	CLIP-seq
MIRT1038278	hsa-miR-1973	CLIP-seq
MIRT1038279	hsa-miR-2114	CLIP-seq
MIRT1038280	hsa-miR-23a	CLIP-seq
MIRT1038281	hsa-miR-23b	CLIP-seq
MIRT1038282	hsa-miR-23c	CLIP-seq
MIRT1038283	hsa-miR-2467-3p	CLIP-seq
MIRT1038284	hsa-miR-2467-5p	CLIP-seq
MIRT1038285	hsa-miR-26a	CLIP-seq
MIRT1038286	hsa-miR-26b	CLIP-seq
MIRT1038287	hsa-miR-296-3p	CLIP-seq
MIRT1038288	hsa-miR-3123	CLIP-seq
MIRT1038289	hsa-miR-3135b	CLIP-seq
MIRT1038290	hsa-miR-3142	CLIP-seq
MIRT1038291	hsa-miR-3156-3p	CLIP-seq
MIRT1038292	hsa-miR-3157-5p	CLIP-seq
MIRT1038293	hsa-miR-3168	CLIP-seq
MIRT1038294	hsa-miR-3188	CLIP-seq
MIRT1038295	hsa-miR-3189-3p	CLIP-seq
MIRT1038296	hsa-miR-3199	CLIP-seq
MIRT1038297	hsa-miR-323-5p	CLIP-seq
MIRT1038298	hsa-miR-338-3p	CLIP-seq
MIRT1038299	hsa-miR-342-3p	CLIP-seq
MIRT1038300	hsa-miR-3652	CLIP-seq
MIRT1038301	hsa-miR-3919	CLIP-seq
MIRT1038302	hsa-miR-3925-3p	CLIP-seq
MIRT1038303	hsa-miR-3960	CLIP-seq
MIRT1038304	hsa-miR-3975	CLIP-seq
MIRT1038305	hsa-miR-4301	CLIP-seq
MIRT1038306	hsa-miR-4430	CLIP-seq
MIRT1038307	hsa-miR-4438	CLIP-seq
MIRT1038308	hsa-miR-4465	CLIP-seq
MIRT1038309	hsa-miR-4467	CLIP-seq
MIRT1038310	hsa-miR-4483	CLIP-seq
MIRT1038311	hsa-miR-4530	CLIP-seq
MIRT1038312	hsa-miR-4646-5p	CLIP-seq
MIRT1038313	hsa-miR-4649-3p	CLIP-seq
MIRT1038314	hsa-miR-4690-3p	CLIP-seq
MIRT1038315	hsa-miR-4701-3p	CLIP-seq
MIRT1038316	hsa-miR-4779	CLIP-seq
MIRT1038317	hsa-miR-485-5p	CLIP-seq
MIRT1038318	hsa-miR-491-3p	CLIP-seq
MIRT1038319	hsa-miR-5095	CLIP-seq
MIRT1038320	hsa-miR-562	CLIP-seq
MIRT1038321	hsa-miR-766	CLIP-seq
MIRT1038322	hsa-miR-885-3p	CLIP-seq
MIRT1038269	hsa-miR-122	CLIP-seq
MIRT1038289	hsa-miR-3135b	CLIP-seq
MIRT1038300	hsa-miR-3652	CLIP-seq
MIRT1038306	hsa-miR-4430	CLIP-seq
MIRT2007836	hsa-miR-4705	CLIP-seq
MIRT2240494	hsa-miR-140-3p	CLIP-seq
MIRT1038275	hsa-miR-150	CLIP-seq
MIRT1038280	hsa-miR-23a	CLIP-seq
MIRT1038281	hsa-miR-23b	CLIP-seq
MIRT1038282	hsa-miR-23c	CLIP-seq
MIRT2240495	hsa-miR-3149	CLIP-seq
MIRT1038291	hsa-miR-3156-3p	CLIP-seq
MIRT1038292	hsa-miR-3157-5p	CLIP-seq
MIRT1038296	hsa-miR-3199	CLIP-seq
MIRT1038305	hsa-miR-4301	CLIP-seq
MIRT1038307	hsa-miR-4438	CLIP-seq
MIRT1038314	hsa-miR-4690-3p	CLIP-seq
MIRT1038319	hsa-miR-5095	CLIP-seq
MIRT2240496	hsa-miR-532-3p	CLIP-seq
MIRT1038320	hsa-miR-562	CLIP-seq
MIRT2240494	hsa-miR-140-3p	CLIP-seq
MIRT1038296	hsa-miR-3199	CLIP-seq
MIRT1038307	hsa-miR-4438	CLIP-seq
MIRT1038319	hsa-miR-5095	CLIP-seq
MIRT2450892	hsa-miR-941	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	20577264
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005881	Component	Cytoplasmic microtubule	IBA	21873635
GO:0005881	Component	Cytoplasmic microtubule	IDA	10974554
GO:0006977	Process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	NAS	10974554
GO:0007017	Process	Microtubule-based process	NAS	10974554
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0015630	Component	Microtubule cytoskeleton	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0030335	Process	Positive regulation of cell migration	TAS
GO:0046827	Process	Positive regulation of protein export from nucleus	TAS
GO:0050821	Process	Protein stabilization	TAS
GO:1900182	Process	Positive regulation of protein localization to nucleus	TAS
GO:1902749	Process	Regulation of cell cycle G2/M phase transition	TAS

Other IDs

• MIM: 607477
• HGNC: 13698
• e!Ensembl: ENSG00000075218

Protein

• UniProt ID: Q9NYZ3
• Protein name: G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)
• Protein function: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
• PDB: 6QNN, 6QNP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15259	GTSE1_N	9 → 152	G-2 and S-phase expressed 1	Family

• Sequence:

  MDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQP
  PLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQ
  ESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARL
  TRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEI
  PASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKA
  PGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPA
  MLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSE
  SSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTS
  VGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCV
  PARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTF
  SKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAH
  VAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF
  

• Sequence length: 720

Pathways

KEGG:

p53 signaling pathway

Reactome:

G2/M Checkpoints
The role of GTSE1 in G2/M progression after G2 checkpoint

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560