UBR5 (ubiquitin protein ligase E3 component n-recognin 5)

Gene

• Entrez ID: 51366
• Gene name: Ubiquitin protein ligase E3 component n-recognin 5
• Gene symbol: UBR5
• Synonyms: DD5, EDD, EDD1, HYD
• Chromosome: 8
• Chromosome location: 8q22.3
• Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016621	hsa-miR-484	Sequencing	20371350
MIRT024039	hsa-miR-1-3p	Proteomics	18668040
MIRT028107	hsa-miR-93-5p	Sequencing	20371350
MIRT031026	hsa-miR-21-5p	Microarray	18591254
MIRT043427	hsa-miR-331-3p	CLASH	23622248
MIRT439352	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439350	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439349	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439352	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439350	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726187	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726188	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028107	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726186	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439349	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT726185	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT726184	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT1471499	hsa-miR-106a	CLIP-seq
MIRT1471500	hsa-miR-106b	CLIP-seq
MIRT1471501	hsa-miR-1178	CLIP-seq
MIRT1471502	hsa-miR-1244	CLIP-seq
MIRT1471503	hsa-miR-1245	CLIP-seq
MIRT1471504	hsa-miR-1284	CLIP-seq
MIRT1471505	hsa-miR-1301	CLIP-seq
MIRT1471506	hsa-miR-140-5p	CLIP-seq
MIRT1471507	hsa-miR-17	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471509	hsa-miR-20a	CLIP-seq
MIRT1471510	hsa-miR-20b	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT1471513	hsa-miR-300	CLIP-seq
MIRT1471514	hsa-miR-3121-5p	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT1471516	hsa-miR-3156-5p	CLIP-seq
MIRT1471517	hsa-miR-3163	CLIP-seq
MIRT1471518	hsa-miR-3182	CLIP-seq
MIRT1471519	hsa-miR-320e	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT1471522	hsa-miR-340	CLIP-seq
MIRT1471523	hsa-miR-3606	CLIP-seq
MIRT1471524	hsa-miR-3609	CLIP-seq
MIRT1471525	hsa-miR-361-5p	CLIP-seq
MIRT1471526	hsa-miR-3670	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471535	hsa-miR-371b-3p	CLIP-seq
MIRT1471536	hsa-miR-381	CLIP-seq
MIRT1471537	hsa-miR-3929	CLIP-seq
MIRT1471538	hsa-miR-3934	CLIP-seq
MIRT1471539	hsa-miR-3938	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471541	hsa-miR-410	CLIP-seq
MIRT1471542	hsa-miR-425	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT1471544	hsa-miR-433	CLIP-seq
MIRT1471545	hsa-miR-4419b	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471548	hsa-miR-4477b	CLIP-seq
MIRT1471549	hsa-miR-4478	CLIP-seq
MIRT1471550	hsa-miR-4499	CLIP-seq
MIRT1471551	hsa-miR-4513	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471553	hsa-miR-4652-3p	CLIP-seq
MIRT1471554	hsa-miR-4659a-3p	CLIP-seq
MIRT1471555	hsa-miR-4659b-3p	CLIP-seq
MIRT1471556	hsa-miR-4666-3p	CLIP-seq
MIRT1471557	hsa-miR-4666-5p	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471559	hsa-miR-4682	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471561	hsa-miR-4719	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT1471563	hsa-miR-4733-3p	CLIP-seq
MIRT1471564	hsa-miR-4753-3p	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471566	hsa-miR-4795-3p	CLIP-seq
MIRT1471567	hsa-miR-4796-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471569	hsa-miR-5047	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471571	hsa-miR-519d	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471575	hsa-miR-548ac	CLIP-seq
MIRT1471576	hsa-miR-548ae	CLIP-seq
MIRT1471577	hsa-miR-548ag	CLIP-seq
MIRT1471578	hsa-miR-548ah	CLIP-seq
MIRT1471579	hsa-miR-548ai	CLIP-seq
MIRT1471580	hsa-miR-548aj	CLIP-seq
MIRT1471581	hsa-miR-548am	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471583	hsa-miR-548b-3p	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT1471585	hsa-miR-548d-3p	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT1471590	hsa-miR-548x	CLIP-seq
MIRT1471591	hsa-miR-548z	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT1471593	hsa-miR-628-5p	CLIP-seq
MIRT1471594	hsa-miR-642a	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT1471596	hsa-miR-889	CLIP-seq
MIRT1471597	hsa-miR-921	CLIP-seq
MIRT1471598	hsa-miR-93	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT2141906	hsa-miR-1825	CLIP-seq
MIRT2141907	hsa-miR-1912	CLIP-seq
MIRT2141908	hsa-miR-1972	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471514	hsa-miR-3121-5p	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2141912	hsa-miR-3170	CLIP-seq
MIRT2141913	hsa-miR-3646	CLIP-seq
MIRT2141914	hsa-miR-3652	CLIP-seq
MIRT2141915	hsa-miR-3662	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT2141916	hsa-miR-3684	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT2141917	hsa-miR-3941	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT2141919	hsa-miR-4430	CLIP-seq
MIRT2141920	hsa-miR-4435	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT2141921	hsa-miR-4505	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT2141922	hsa-miR-4731-5p	CLIP-seq
MIRT2141923	hsa-miR-4755-3p	CLIP-seq
MIRT2141924	hsa-miR-4775	CLIP-seq
MIRT2141925	hsa-miR-4781-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT2141926	hsa-miR-570	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141929	hsa-miR-590-3p	CLIP-seq
MIRT2141930	hsa-miR-626	CLIP-seq
MIRT1471593	hsa-miR-628-5p	CLIP-seq
MIRT2141931	hsa-miR-647	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT2141933	hsa-miR-9	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT1471524	hsa-miR-3609	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT2141917	hsa-miR-3941	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471542	hsa-miR-425	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471548	hsa-miR-4477b	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471563	hsa-miR-4733-3p	CLIP-seq
MIRT1471577	hsa-miR-548ag	CLIP-seq
MIRT1471578	hsa-miR-548ah	CLIP-seq
MIRT1471579	hsa-miR-548ai	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2462825	hsa-miR-3591-3p	CLIP-seq
MIRT2141913	hsa-miR-3646	CLIP-seq
MIRT2141915	hsa-miR-3662	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT2656489	hsa-miR-105	CLIP-seq
MIRT1471499	hsa-miR-106a	CLIP-seq
MIRT1471500	hsa-miR-106b	CLIP-seq
MIRT2656490	hsa-miR-1179	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT1471507	hsa-miR-17	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471509	hsa-miR-20a	CLIP-seq
MIRT1471510	hsa-miR-20b	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2656491	hsa-miR-3189-5p	CLIP-seq
MIRT2656492	hsa-miR-328	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT2656493	hsa-miR-3613-3p	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471535	hsa-miR-371b-3p	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT2656494	hsa-miR-4273	CLIP-seq
MIRT2656495	hsa-miR-4290	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471557	hsa-miR-4666-5p	CLIP-seq
MIRT2656496	hsa-miR-4677-5p	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT2141925	hsa-miR-4781-3p	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471571	hsa-miR-519d	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT2656497	hsa-miR-888	CLIP-seq
MIRT1471598	hsa-miR-93	CLIP-seq
MIRT2656490	hsa-miR-1179	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2656491	hsa-miR-3189-5p	CLIP-seq
MIRT2656492	hsa-miR-328	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA	21873635
GO:0000209	Process	Protein polyubiquitination	IDA	21118991, 28689657
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12011095, 16601676, 21118991
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	12011095, 21118991, 28689657
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	Cellular response to DNA damage stimulus	IBA	21873635
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	12011095
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	22884692
GO:0008270	Function	Zinc ion binding	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	18076571
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0032991	Component	Protein-containing complex	IDA	18076571
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IDA	21118991
GO:0042307	Process	Positive regulation of protein import into nucleus	IMP	21118991
GO:0043130	Function	Ubiquitin binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18076571
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	12011095
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	28689657
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	28689657
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	21118991, 28689657
GO:1901315	Process	Negative regulation of histone H2A K63-linked ubiquitination	IBA	21873635
GO:1901315	Process	Negative regulation of histone H2A K63-linked ubiquitination	IMP	22884692
GO:2000779	Process	Regulation of double-strand break repair	IBA	21873635
GO:2000780	Process	Negative regulation of double-strand break repair	IMP	22884692

Other IDs

• MIM: 608413
• HGNC: 16806
• e!Ensembl: ENSG00000104517

Protein

• UniProt ID: O95071
• Protein name: E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
• Protein function: E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubi
• PDB: 1I2T, 2QHO, 3PT3, 8BJA, 8C06, 8C07, 8D4X, 8E0Q, 8EWI, 8P82, 8P83
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11547	E3_UbLigase_EDD	179 → 230	E3 ubiquitin ligase EDD	Domain
  PF00658	PABP	2385 → 2449	Poly-adenylate binding protein, unique domain	Family
  PF00632	HECT	2498 → 2799	HECT-domain (ubiquitin-transferase)	Domain

• Sequence:

  MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
  LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
  GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
  PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
  SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
  LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
  QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
  NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
  LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
  LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
  EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
  DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
  TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
  ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
  ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
  LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
  AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
  IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
  RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
  KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
  LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
  ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
  PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
  DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
  VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
  STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
  QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
  ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
  SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
  SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
  LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
  SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
  ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
  LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
  EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
  KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
  SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
  KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
  FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
  EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
  LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
  ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
  NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
  QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
  HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
  GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
  HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV

• Sequence length: 2799

Pathways

KEGG:

Ubiquitin mediated proteolysis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Colorectal cancer	Adenocarcinoma of large intestine	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Unknown
Disease name	Disease term	dbSNP ID	References
Benign neoplasm of stomach	Benign neoplasm of stomach
Impaired cognition	Impaired cognition		22833209
Malignant lymphoma, lymphocytic, intermediate differentiation	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms
Stomach carcinoma	Stomach Carcinoma, Carcinoma in situ of stomach