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TNFRSF12A (TNF receptor superfamily member 12A)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51330
Gene nameGene Name - the full gene name approved by the HGNC.
TNF receptor superfamily member 12A
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TNFRSF12A
SynonymsGene synonyms aliases
CD266, FN14, TWEAKR
ChromosomeChromosome number
16
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT022342 hsa-miR-124-3p Microarray 18668037
MIRT031460 hsa-miR-16-5p Proteomics 18668040
MIRT042306 hsa-miR-484 CLASH 23622248
MIRT142988 hsa-miR-19a-3p HITS-CLIP 22473208
MIRT142988 hsa-miR-19a-3p Luciferase reporter assay, qRT-PCR, Western blot 26367773
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
MAML1 Repression 18503747
NR1I2 Activation 21072196
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0005515 Function Protein binding IPI 11728344, 21525013, 23438059, 25416956, 31515488, 32296183
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0006915 Process Apoptotic process IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NP84
Protein name Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)
Protein function Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
PDB 2EQP , 2KMZ , 2RPJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12191 stn_TNFRSF12A
1 → 129
Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
 Domain
Sequence
Sequence length 129
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Cytokine-cytokine receptor interaction   TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Myocardial infarction Myocardial Infarction rs12316150, rs41303970, rs909253, rs7291467, rs2234693 20082609
Unknown
Disease name Disease term dbSNP ID References
Kidney failure Kidney Failure, Acute 23052191
Acute kidney insufficiency Acute Kidney Insufficiency 23052191

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