TLR8 (toll like receptor 8)

Gene

• Entrez ID: 51311
• Gene name: Toll like receptor 8
• Gene symbol: TLR8
• Synonyms: CD288, IMD98, TLR-8, hTLR8
• Chromosome: X
• Chromosome location: Xp22.2
• Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT650804	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650803	hsa-miR-891b	HITS-CLIP	23824327
MIRT650804	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650803	hsa-miR-891b	HITS-CLIP	23824327
MIRT735683	hsa-miR-340-3p	Immunofluorescence	31940779
MIRT735684	hsa-miR-132-5p	Immunofluorescence	31940779
MIRT736440	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT650804	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650803	hsa-miR-891b	HITS-CLIP	23824327
MIRT650804	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650803	hsa-miR-891b	HITS-CLIP	23824327
MIRT1427040	hsa-miR-125a-5p	CLIP-seq
MIRT1427041	hsa-miR-125b	CLIP-seq
MIRT1427042	hsa-miR-1301	CLIP-seq
MIRT1427043	hsa-miR-3613-3p	CLIP-seq
MIRT1427044	hsa-miR-3620	CLIP-seq
MIRT1427045	hsa-miR-3690	CLIP-seq
MIRT1427046	hsa-miR-371b-5p	CLIP-seq
MIRT1427047	hsa-miR-378	CLIP-seq
MIRT1427048	hsa-miR-378b	CLIP-seq
MIRT1427049	hsa-miR-378c	CLIP-seq
MIRT1427050	hsa-miR-378d	CLIP-seq
MIRT1427051	hsa-miR-378e	CLIP-seq
MIRT1427052	hsa-miR-378f	CLIP-seq
MIRT1427053	hsa-miR-378h	CLIP-seq
MIRT1427054	hsa-miR-378i	CLIP-seq
MIRT1427055	hsa-miR-3921	CLIP-seq
MIRT1427056	hsa-miR-410	CLIP-seq
MIRT1427057	hsa-miR-422a	CLIP-seq
MIRT1427058	hsa-miR-4251	CLIP-seq
MIRT1427059	hsa-miR-4319	CLIP-seq
MIRT1427060	hsa-miR-4329	CLIP-seq
MIRT1427061	hsa-miR-4459	CLIP-seq
MIRT1427062	hsa-miR-4653-5p	CLIP-seq
MIRT1427063	hsa-miR-4725-5p	CLIP-seq
MIRT1427064	hsa-miR-504	CLIP-seq
MIRT1427065	hsa-miR-5047	CLIP-seq
MIRT1427066	hsa-miR-548a-3p	CLIP-seq
MIRT1427067	hsa-miR-548ae	CLIP-seq
MIRT1427068	hsa-miR-548aj	CLIP-seq
MIRT1427069	hsa-miR-548am	CLIP-seq
MIRT1427070	hsa-miR-548e	CLIP-seq
MIRT1427071	hsa-miR-548f	CLIP-seq
MIRT1427072	hsa-miR-548g	CLIP-seq
MIRT1427073	hsa-miR-548x	CLIP-seq
MIRT1427074	hsa-miR-570	CLIP-seq
MIRT1427075	hsa-miR-665	CLIP-seq
MIRT2127948	hsa-miR-1972	CLIP-seq
MIRT2127949	hsa-miR-4274	CLIP-seq
MIRT2127950	hsa-miR-4436a	CLIP-seq
MIRT2127951	hsa-miR-4690-5p	CLIP-seq
MIRT2349577	hsa-miR-1269	CLIP-seq
MIRT2349578	hsa-miR-1269b	CLIP-seq
MIRT2349579	hsa-miR-1288	CLIP-seq
MIRT2349580	hsa-miR-323-5p	CLIP-seq
MIRT1427045	hsa-miR-3690	CLIP-seq
MIRT1427047	hsa-miR-378	CLIP-seq
MIRT1427048	hsa-miR-378b	CLIP-seq
MIRT1427049	hsa-miR-378c	CLIP-seq
MIRT1427050	hsa-miR-378d	CLIP-seq
MIRT1427051	hsa-miR-378e	CLIP-seq
MIRT1427052	hsa-miR-378f	CLIP-seq
MIRT1427053	hsa-miR-378h	CLIP-seq
MIRT1427054	hsa-miR-378i	CLIP-seq
MIRT1427057	hsa-miR-422a	CLIP-seq
MIRT2349581	hsa-miR-4292	CLIP-seq
MIRT2349582	hsa-miR-4308	CLIP-seq
MIRT2349583	hsa-miR-4446-5p	CLIP-seq
MIRT2349584	hsa-miR-4502	CLIP-seq
MIRT2349585	hsa-miR-4515	CLIP-seq
MIRT2349586	hsa-miR-4740-5p	CLIP-seq
MIRT2349587	hsa-miR-4755-5p	CLIP-seq
MIRT2349588	hsa-miR-621	CLIP-seq
MIRT2349589	hsa-miR-670	CLIP-seq
MIRT2643097	hsa-miR-1298	CLIP-seq
MIRT2643098	hsa-miR-3658	CLIP-seq
MIRT2643099	hsa-miR-579	CLIP-seq
MIRT2643100	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001774	Process	Microglial cell activation	IEA
GO:0001932	Process	Regulation of protein phosphorylation	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	IBA	21873635
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	IEA
GO:0003677	Function	DNA binding	IDA	16123302
GO:0003723	Function	RNA binding	TAS	16123302
GO:0003725	Function	Double-stranded RNA binding	IDA	16111635
GO:0003727	Function	Single-stranded RNA binding	IDA	14976262, 24942581
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IBA	21873635
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	IDA	12032557
GO:0008144	Function	Drug binding	IEA
GO:0009615	Process	Response to virus	IDA	12032557
GO:0009897	Component	External side of plasma membrane	IDA	24942581
GO:0010008	Component	Endosome membrane	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0016064	Process	Immunoglobulin mediated immune response	TAS	16123302
GO:0032695	Process	Negative regulation of interleukin-12 production	IDA	24942581
GO:0032727	Process	Positive regulation of interferon-alpha production	IDA	16286015
GO:0032728	Process	Positive regulation of interferon-beta production	IDA	16286015
GO:0032729	Process	Positive regulation of interferon-gamma production	IDA	16286015
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IDA	24942581
GO:0032755	Process	Positive regulation of interleukin-6 production	IBA	21873635
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	24942581
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	16188996
GO:0034158	Process	Toll-like receptor 8 signaling pathway	IDA	24942581
GO:0034162	Process	Toll-like receptor 9 signaling pathway	TAS
GO:0036020	Component	Endolysosome membrane	TAS
GO:0038023	Function	Signaling receptor activity	NAS	12032557
GO:0038187	Function	Pattern recognition receptor activity	IBA	21873635
GO:0045087	Process	Innate immune response	NAS	12032557
GO:0045089	Process	Positive regulation of innate immune response	IDA	16123302
GO:0051607	Process	Defense response to virus	IBA	21873635
GO:0051607	Process	Defense response to virus	IMP	16188996
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445

Other IDs

• MIM: 300366
• HGNC: 15632
• e!Ensembl: ENSG00000101916

Protein

• UniProt ID: Q9NR97
• Protein name: Toll-like receptor 8 (CD antigen CD288)
• Protein function: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are init
• PDB: 3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWA, 5AWB, 5AWC, 5AWD, 5AZ5, 5HDH, 5WYX, 5WYZ, 5Z14, 5Z15, 6KYA, 6TY5, 6V9U, 6WML, 6ZJZ, 7CRF, 7R52, 7R53, 7R54, 7RC9, 7YTX, 8PFI, 9MHW, 9MHX, 9MHY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00560	LRR_1	65 → 86	Leucine Rich Repeat	Repeat
  PF13855	LRR_8	276 → 323	Leucine rich repeat	Repeat
  PF13855	LRR_8	639 → 700	Leucine rich repeat	Repeat
  PF13855	LRR_8	712 → 774	Leucine rich repeat	Repeat
  PF01582	TIR	879 → 1039	TIR domain	Family

• Sequence:

  MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
  VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
  FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
  CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
  DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
  KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
  RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
  EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
  AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
  RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
  DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
  NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
  HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
  GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
  MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
  LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
  YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
  VVLTENDSRYNNMYVDSIKQY

• Sequence length: 1041

Pathways

KEGG:

Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
Coronavirus disease - COVID-19

Reactome:

Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174