NRN1 (neuritin 1)

Gene

• Entrez ID: 51299
• Gene name: Neuritin 1
• Gene symbol: NRN1
• Synonyms: NRN, dJ380B8.2
• Chromosome: 6
• Chromosome location: 6p25.1
• Summary: This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by n

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028913	hsa-miR-26b-5p	Microarray	19088304
MIRT050310	hsa-miR-25-3p	CLASH	23622248
MIRT049996	hsa-miR-28-5p	CLASH	23622248
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT626909	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT626908	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT626907	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT626906	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT626905	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT1194313	hsa-miR-103a	CLIP-seq
MIRT1194314	hsa-miR-107	CLIP-seq
MIRT1194315	hsa-miR-129-5p	CLIP-seq
MIRT1194316	hsa-miR-15a	CLIP-seq
MIRT1194317	hsa-miR-15b	CLIP-seq
MIRT1194318	hsa-miR-16	CLIP-seq
MIRT1194319	hsa-miR-195	CLIP-seq
MIRT1194320	hsa-miR-3123	CLIP-seq
MIRT1194321	hsa-miR-3129-3p	CLIP-seq
MIRT1194322	hsa-miR-3133	CLIP-seq
MIRT1194323	hsa-miR-3659	CLIP-seq
MIRT1194324	hsa-miR-3919	CLIP-seq
MIRT1194325	hsa-miR-424	CLIP-seq
MIRT1194326	hsa-miR-4276	CLIP-seq
MIRT1194327	hsa-miR-4291	CLIP-seq
MIRT1194328	hsa-miR-4310	CLIP-seq
MIRT1194329	hsa-miR-4511	CLIP-seq
MIRT1194330	hsa-miR-4524	CLIP-seq
MIRT1194331	hsa-miR-4680-3p	CLIP-seq
MIRT1194332	hsa-miR-4775	CLIP-seq
MIRT1194333	hsa-miR-497	CLIP-seq
MIRT1194334	hsa-miR-503	CLIP-seq
MIRT1194335	hsa-miR-591	CLIP-seq
MIRT1194336	hsa-miR-628-5p	CLIP-seq
MIRT1194337	hsa-miR-646	CLIP-seq
MIRT2056404	hsa-miR-1284	CLIP-seq
MIRT2056405	hsa-miR-4684-5p	CLIP-seq
MIRT1194315	hsa-miR-129-5p	CLIP-seq
MIRT1194320	hsa-miR-3123	CLIP-seq
MIRT1194323	hsa-miR-3659	CLIP-seq
MIRT2284933	hsa-miR-374a	CLIP-seq
MIRT2284934	hsa-miR-374b	CLIP-seq
MIRT1194324	hsa-miR-3919	CLIP-seq
MIRT1194327	hsa-miR-4291	CLIP-seq
MIRT1194328	hsa-miR-4310	CLIP-seq
MIRT2284935	hsa-miR-4658	CLIP-seq
MIRT1194331	hsa-miR-4680-3p	CLIP-seq
MIRT1194332	hsa-miR-4775	CLIP-seq
MIRT2284936	hsa-miR-574-5p	CLIP-seq
MIRT1194336	hsa-miR-628-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007399	Process	Nervous system development	IEA
GO:0031225	Component	Anchored component of membrane	IEA
GO:0045202	Component	Synapse	IEA

Other IDs

• MIM: 607409
• HGNC: 17972
• e!Ensembl: ENSG00000124785

Protein

• UniProt ID: Q9NPD7
• Protein name: Neuritin
• Protein function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15056	NRN1	31 → 117	Neuritin protein family	Domain

• Sequence:

  MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKT
  NIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGS
  LLPAFPVLLVSLSAALATWLSF

• Sequence length: 142

Pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19569075