TLR7 (toll like receptor 7)

Gene

• Entrez ID: 51284
• Gene name: Toll like receptor 7
• Gene symbol: TLR7
• Synonyms: IMD74, SLEB17, TLR7-like
• Chromosome: X
• Chromosome location: Xp22.2
• Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT438602	hsa-miR-758-3p	Luciferase reporter assay, Western blot, qRT-PCR	25008898
MIRT438602	hsa-miR-758-3p	Luciferase reporter assay, Western blot, qRT-PCR	25008898
MIRT684099	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684098	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684097	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684096	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684095	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684094	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684093	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684092	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684091	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684090	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684089	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684088	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684087	hsa-miR-302e	HITS-CLIP	23313552
MIRT684086	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684085	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684084	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684083	hsa-miR-520b	HITS-CLIP	23313552
MIRT684082	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684081	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684080	hsa-miR-520e	HITS-CLIP	23313552
MIRT684079	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684078	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684077	hsa-miR-520h	HITS-CLIP	23313552
MIRT684076	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684074	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT684073	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT684072	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT684071	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684070	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684069	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684068	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684067	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684066	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT684065	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT684099	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684098	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684097	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684096	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684095	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684094	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684093	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684092	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684091	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684090	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684089	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684088	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684087	hsa-miR-302e	HITS-CLIP	23313552
MIRT684086	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684085	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684084	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684083	hsa-miR-520b	HITS-CLIP	23313552
MIRT684082	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684081	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684080	hsa-miR-520e	HITS-CLIP	23313552
MIRT684079	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684078	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684077	hsa-miR-520h	HITS-CLIP	23313552
MIRT684076	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684075	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT684074	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT684073	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT684072	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT684071	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684070	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684069	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684068	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684067	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684066	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT684065	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT449487	hsa-miR-8087	PAR-CLIP	22100165
MIRT449486	hsa-miR-586	PAR-CLIP	22100165
MIRT684097	hsa-miR-17-5p	Luciferase reporter assay	26041742
MIRT734567	hsa-let-7b-3p	qRT-PCR, Flow cytometry	33079387
MIRT735682	hsa-miR-132-5p	Immunofluorescence	31940779
MIRT736103	hsa-let-7a-3p	Microarray	31540501
MIRT684099	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684098	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684097	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684096	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684095	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684094	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684093	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684092	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684091	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684090	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684089	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684088	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684087	hsa-miR-302e	HITS-CLIP	23313552
MIRT684086	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684085	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684084	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684083	hsa-miR-520b	HITS-CLIP	23313552
MIRT684082	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684081	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684080	hsa-miR-520e	HITS-CLIP	23313552
MIRT684079	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684078	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684077	hsa-miR-520h	HITS-CLIP	23313552
MIRT684076	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684074	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT684073	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT684072	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT684071	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684070	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684069	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684068	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684067	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684066	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT684065	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT684099	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684098	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684097	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684096	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684095	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684094	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684093	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684092	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684091	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684090	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684089	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684088	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684087	hsa-miR-302e	HITS-CLIP	23313552
MIRT684086	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684085	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684084	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684083	hsa-miR-520b	HITS-CLIP	23313552
MIRT684082	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684081	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684080	hsa-miR-520e	HITS-CLIP	23313552
MIRT684079	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684078	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684077	hsa-miR-520h	HITS-CLIP	23313552
MIRT684076	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684075	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT684074	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT684073	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT684072	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT684071	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684070	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684069	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684068	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684067	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684066	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT684065	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT449487	hsa-miR-8087	PAR-CLIP	22100165
MIRT449486	hsa-miR-586	PAR-CLIP	22100165
MIRT755537	hsa-miR-146a-5p	Luciferase reporter assay, Western blotting, Flow cytometry, ELISA	34808293
MIRT755537	hsa-miR-146a-5p	Western blotting, qRT-PCR	36210830
MIRT1427013	hsa-miR-1267	CLIP-seq
MIRT1427014	hsa-miR-1307	CLIP-seq
MIRT1427015	hsa-miR-150	CLIP-seq
MIRT1427016	hsa-miR-1912	CLIP-seq
MIRT1427017	hsa-miR-1976	CLIP-seq
MIRT1427018	hsa-miR-3136-3p	CLIP-seq
MIRT1427019	hsa-miR-3688-3p	CLIP-seq
MIRT1427020	hsa-miR-4269	CLIP-seq
MIRT1427021	hsa-miR-4275	CLIP-seq
MIRT1427022	hsa-miR-4279	CLIP-seq
MIRT1427023	hsa-miR-4284	CLIP-seq
MIRT1427024	hsa-miR-4422	CLIP-seq
MIRT1427025	hsa-miR-4438	CLIP-seq
MIRT1427026	hsa-miR-4532	CLIP-seq
MIRT1427027	hsa-miR-4638-5p	CLIP-seq
MIRT1427028	hsa-miR-4652-3p	CLIP-seq
MIRT1427029	hsa-miR-4690-5p	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT1427031	hsa-miR-4722-3p	CLIP-seq
MIRT1427032	hsa-miR-4778-3p	CLIP-seq
MIRT1427033	hsa-miR-488	CLIP-seq
MIRT1427034	hsa-miR-495	CLIP-seq
MIRT1427035	hsa-miR-498	CLIP-seq
MIRT1427036	hsa-miR-5095	CLIP-seq
MIRT1427037	hsa-miR-562	CLIP-seq
MIRT1427038	hsa-miR-659	CLIP-seq
MIRT1427039	hsa-miR-944	CLIP-seq
MIRT1427014	hsa-miR-1307	CLIP-seq
MIRT2127929	hsa-miR-197	CLIP-seq
MIRT2127930	hsa-miR-3149	CLIP-seq
MIRT2127931	hsa-miR-3187-3p	CLIP-seq
MIRT2127932	hsa-miR-3663-5p	CLIP-seq
MIRT2127933	hsa-miR-371-5p	CLIP-seq
MIRT2127934	hsa-miR-371b-5p	CLIP-seq
MIRT1427023	hsa-miR-4284	CLIP-seq
MIRT2127935	hsa-miR-4435	CLIP-seq
MIRT1427025	hsa-miR-4438	CLIP-seq
MIRT2127936	hsa-miR-4463	CLIP-seq
MIRT2127937	hsa-miR-4494	CLIP-seq
MIRT1427027	hsa-miR-4638-5p	CLIP-seq
MIRT2127938	hsa-miR-4701-5p	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT2127939	hsa-miR-4716-5p	CLIP-seq
MIRT2127940	hsa-miR-4735-5p	CLIP-seq
MIRT2127941	hsa-miR-4775	CLIP-seq
MIRT2127942	hsa-miR-4781-3p	CLIP-seq
MIRT1427036	hsa-miR-5095	CLIP-seq
MIRT2127943	hsa-miR-5096	CLIP-seq
MIRT2127944	hsa-miR-548s	CLIP-seq
MIRT2127945	hsa-miR-588	CLIP-seq
MIRT2127946	hsa-miR-590-3p	CLIP-seq
MIRT2127947	hsa-miR-640	CLIP-seq
MIRT1427014	hsa-miR-1307	CLIP-seq
MIRT1427015	hsa-miR-150	CLIP-seq
MIRT2127929	hsa-miR-197	CLIP-seq
MIRT2127930	hsa-miR-3149	CLIP-seq
MIRT2127931	hsa-miR-3187-3p	CLIP-seq
MIRT2349566	hsa-miR-338-3p	CLIP-seq
MIRT1427020	hsa-miR-4269	CLIP-seq
MIRT1427023	hsa-miR-4284	CLIP-seq
MIRT2127935	hsa-miR-4435	CLIP-seq
MIRT1427025	hsa-miR-4438	CLIP-seq
MIRT2127936	hsa-miR-4463	CLIP-seq
MIRT2127937	hsa-miR-4494	CLIP-seq
MIRT2349567	hsa-miR-4530	CLIP-seq
MIRT1427027	hsa-miR-4638-5p	CLIP-seq
MIRT2349568	hsa-miR-4659a-3p	CLIP-seq
MIRT2349569	hsa-miR-4659b-3p	CLIP-seq
MIRT2349570	hsa-miR-4691-5p	CLIP-seq
MIRT2349571	hsa-miR-4695-3p	CLIP-seq
MIRT2127938	hsa-miR-4701-5p	CLIP-seq
MIRT2349572	hsa-miR-4713-5p	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT2127939	hsa-miR-4716-5p	CLIP-seq
MIRT2127940	hsa-miR-4735-5p	CLIP-seq
MIRT2127941	hsa-miR-4775	CLIP-seq
MIRT2127942	hsa-miR-4781-3p	CLIP-seq
MIRT2349573	hsa-miR-483-5p	CLIP-seq
MIRT1427036	hsa-miR-5095	CLIP-seq
MIRT2127943	hsa-miR-5096	CLIP-seq
MIRT2349574	hsa-miR-532-3p	CLIP-seq
MIRT2127944	hsa-miR-548s	CLIP-seq
MIRT1427037	hsa-miR-562	CLIP-seq
MIRT2127945	hsa-miR-588	CLIP-seq
MIRT2127946	hsa-miR-590-3p	CLIP-seq
MIRT2127947	hsa-miR-640	CLIP-seq
MIRT2349575	hsa-miR-766	CLIP-seq
MIRT2349576	hsa-miR-942	CLIP-seq
MIRT1427015	hsa-miR-150	CLIP-seq
MIRT1427017	hsa-miR-1976	CLIP-seq
MIRT1427020	hsa-miR-4269	CLIP-seq
MIRT1427022	hsa-miR-4279	CLIP-seq
MIRT1427025	hsa-miR-4438	CLIP-seq
MIRT1427026	hsa-miR-4532	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT1427031	hsa-miR-4722-3p	CLIP-seq
MIRT1427035	hsa-miR-498	CLIP-seq
MIRT1427036	hsa-miR-5095	CLIP-seq
MIRT1427037	hsa-miR-562	CLIP-seq
MIRT1427015	hsa-miR-150	CLIP-seq
MIRT1427017	hsa-miR-1976	CLIP-seq
MIRT2127930	hsa-miR-3149	CLIP-seq
MIRT1427022	hsa-miR-4279	CLIP-seq
MIRT1427026	hsa-miR-4532	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT1427031	hsa-miR-4722-3p	CLIP-seq
MIRT2127940	hsa-miR-4735-5p	CLIP-seq
MIRT2127941	hsa-miR-4775	CLIP-seq
MIRT2349573	hsa-miR-483-5p	CLIP-seq
MIRT1427035	hsa-miR-498	CLIP-seq
MIRT2127946	hsa-miR-590-3p	CLIP-seq
MIRT2643094	hsa-miR-101	CLIP-seq
MIRT2643095	hsa-miR-1261	CLIP-seq
MIRT2643096	hsa-miR-144	CLIP-seq
MIRT1427015	hsa-miR-150	CLIP-seq
MIRT1427017	hsa-miR-1976	CLIP-seq
MIRT2127930	hsa-miR-3149	CLIP-seq
MIRT1427020	hsa-miR-4269	CLIP-seq
MIRT1427022	hsa-miR-4279	CLIP-seq
MIRT1427025	hsa-miR-4438	CLIP-seq
MIRT1427026	hsa-miR-4532	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT1427031	hsa-miR-4722-3p	CLIP-seq
MIRT2127940	hsa-miR-4735-5p	CLIP-seq
MIRT2127941	hsa-miR-4775	CLIP-seq
MIRT2349573	hsa-miR-483-5p	CLIP-seq
MIRT1427035	hsa-miR-498	CLIP-seq
MIRT1427036	hsa-miR-5095	CLIP-seq
MIRT1427037	hsa-miR-562	CLIP-seq
MIRT2127946	hsa-miR-590-3p	CLIP-seq
MIRT2693231	hsa-miR-1323	CLIP-seq
MIRT1427015	hsa-miR-150	CLIP-seq
MIRT1427017	hsa-miR-1976	CLIP-seq
MIRT2127930	hsa-miR-3149	CLIP-seq
MIRT1427020	hsa-miR-4269	CLIP-seq
MIRT1427022	hsa-miR-4279	CLIP-seq
MIRT1427025	hsa-miR-4438	CLIP-seq
MIRT1427026	hsa-miR-4532	CLIP-seq
MIRT1427030	hsa-miR-4715-3p	CLIP-seq
MIRT1427031	hsa-miR-4722-3p	CLIP-seq
MIRT2127940	hsa-miR-4735-5p	CLIP-seq
MIRT2127941	hsa-miR-4775	CLIP-seq
MIRT1427035	hsa-miR-498	CLIP-seq
MIRT1427036	hsa-miR-5095	CLIP-seq
MIRT2693232	hsa-miR-548aa	CLIP-seq
MIRT2693233	hsa-miR-548o	CLIP-seq
MIRT1427037	hsa-miR-562	CLIP-seq
MIRT2127946	hsa-miR-590-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFKB1	Activation	16423052;20658750
RELA	Activation	16423052;20658750

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001774	Process	Microglial cell activation	IEA
GO:0001932	Process	Regulation of protein phosphorylation	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	IBA	21873635
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0003725	Function	Double-stranded RNA binding	IDA	16111635
GO:0003727	Function	Single-stranded RNA binding	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005737	Component	Cytoplasm	IDA	19740627
GO:0005764	Component	Lysosome	ISS
GO:0005768	Component	Endosome	ISS
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	19740627
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IBA	21873635
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0007252	Process	I-kappaB phosphorylation	IDA	19740627
GO:0008144	Function	Drug binding	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0032009	Component	Early phagosome	ISS
GO:0032722	Process	Positive regulation of chemokine production	IDA	19740627
GO:0032727	Process	Positive regulation of interferon-alpha production	IDA	16286015
GO:0032728	Process	Positive regulation of interferon-beta production	IDA	16286015
GO:0032729	Process	Positive regulation of interferon-gamma production	IDA	16286015
GO:0032755	Process	Positive regulation of interleukin-6 production	IBA	21873635
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	19740627
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	16188996
GO:0034154	Process	Toll-like receptor 7 signaling pathway	IBA	21873635
GO:0034162	Process	Toll-like receptor 9 signaling pathway	TAS
GO:0035197	Function	SiRNA binding	ISS
GO:0036020	Component	Endolysosome membrane	TAS
GO:0038187	Function	Pattern recognition receptor activity	IBA	21873635
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045087	Process	Innate immune response	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IC	19740627
GO:0051607	Process	Defense response to virus	IBA	21873635
GO:0051607	Process	Defense response to virus	IMP	16188996
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:1901224	Process	Positive regulation of NIK/NF-kappaB signaling	IDA	19740627

Other IDs

• MIM: 300365
• HGNC: 15631
• e!Ensembl: ENSG00000196664

Protein

• UniProt ID: Q9NYK1
• Protein name: Toll-like receptor 7
• Protein function: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or
• PDB: 7CYN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	496 → 554	Leucine rich repeat	Repeat
  PF00560	LRR_1	700 → 743	Leucine Rich Repeat	Repeat
  PF01582	TIR	890 → 1048	TIR domain	Family

• Sequence:

  MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
  GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
  RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
  QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
  QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
  SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
  NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
  KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
  EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
  LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
  LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
  SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
  CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
  HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
  ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
  DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
  YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
  AHPYFWQCLKNALATDNHVAYSQVFKETV

• Sequence length: 1049

Pathways

KEGG:

Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
Measles
Influenza A
Coronavirus disease - COVID-19

Reactome:

Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	25226551