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CRIM1 (cysteine rich transmembrane BMP regulator 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51232
Gene nameGene Name - the full gene name approved by the HGNC.
Cysteine rich transmembrane BMP regulator 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CRIM1
SynonymsGene synonyms aliases
CRIM-1, S52
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p22.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth f
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004053 hsa-miR-20b-5p Luciferase reporter assay, qRT-PCR 21042576
MIRT004053 hsa-miR-20b-5p Luciferase reporter assay, qRT-PCR 21042576
MIRT006756 hsa-miR-20a-5p Luciferase reporter assay 21743293
MIRT006756 hsa-miR-20a-5p Luciferase reporter assay 21743293
MIRT020040 hsa-miR-375 Microarray 20215506
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0005010 Function Insulin-like growth factor-activated receptor activity TAS 10642437
GO:0005520 Function Insulin-like growth factor binding IEA
GO:0005576 Component Extracellular region IEA
GO:0005886 Component Plasma membrane IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NZV1
Protein name Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein]
Protein function May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its pr
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00219 IGFBP
37 90
Insulin-like growth factor binding protein
Domain
PF00093 VWC
336 390
von Willebrand factor type C domain
Family
PF00093 VWC
403 456
von Willebrand factor type C domain
Family
PF02822 Antistasin
469 498
Antistasin family
Domain
PF02822 Antistasin
505 532
Antistasin family
Domain
PF02822 Antistasin
539 564
Antistasin family
Domain
PF02822 Antistasin
567 592
Antistasin family
Domain
PF00093 VWC
608 662
von Willebrand factor type C domain
Family
PF00093 VWC
679 734
von Willebrand factor type C domain
Family
PF00093 VWC
753 808
von Willebrand factor type C domain
Family
PF00093 VWC
819 873
von Willebrand factor type C domain
Family
Sequence
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVC
GCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLL
GFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGE
CCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGF
PVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ
GGVAICFTAQCGEINCERYYVPEGECCPVC
EDPVYPFNNPAGCYANGLILAHGDRWREDD
CTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVC
EEPTIITVDPPACGELSNCTLTGK
DCINGFKRDHNGCRTCQC
INTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCR
PIICDKYCPLGLLKNKHGCDICRC
KKCPELSCSKICPLGFQQDSHGCLICKCREASASAG
PPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCP
SC
ADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC
QNPSRTQDSCCPQC
TDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDS
VISCFSESCPSVSCERPVLRKGQCCPYC
IEDTIPKKVVCHFSGKAYADEERWDLDSCTHC
YCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC
PEMYVPEPTNIPIEKTNHRGEVDLEVP
LWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFI
NQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYS
MQKQNHLQADNFYQTV
Sequence length 1036
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 23967269
Unknown
Disease name Disease term dbSNP ID References
Macrophthalmia, colobomatous, with microcornea Colobomatous macrophthalmia-microcornea syndrome, MACROPHTHALMIA, COLOBOMATOUS, WITH MICROCORNEA 25561690, 26681494

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