PCSK1 (proprotein convertase subtilisin/kexin type 1)

Gene

• Entrez ID: 5122
• Gene name: Proprotein convertase subtilisin/kexin type 1
• Gene symbol: PCSK1
• Synonyms: BMIQ12, NEC1, PC1, PC1/3, PC3, SPC3
• Chromosome: 5
• Chromosome location: 5q15
• Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein under

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029995	hsa-miR-26b-5p	Microarray	19088304
MIRT530376	hsa-miR-3156-5p	PAR-CLIP	22012620
MIRT530375	hsa-miR-1179	PAR-CLIP	22012620
MIRT530374	hsa-miR-892c-5p	PAR-CLIP	22012620
MIRT530373	hsa-miR-10b-3p	PAR-CLIP	22012620
MIRT530372	hsa-miR-5100	PAR-CLIP	22012620
MIRT530371	hsa-miR-518d-5p	PAR-CLIP	22012620
MIRT530370	hsa-miR-518e-5p	PAR-CLIP	22012620
MIRT530369	hsa-miR-518f-5p	PAR-CLIP	22012620
MIRT530368	hsa-miR-519a-5p	PAR-CLIP	22012620
MIRT530367	hsa-miR-519b-5p	PAR-CLIP	22012620
MIRT530366	hsa-miR-519c-5p	PAR-CLIP	22012620
MIRT530365	hsa-miR-520c-5p	PAR-CLIP	22012620
MIRT530364	hsa-miR-522-5p	PAR-CLIP	22012620
MIRT530363	hsa-miR-523-5p	PAR-CLIP	22012620
MIRT530362	hsa-miR-526a	PAR-CLIP	22012620
MIRT530361	hsa-miR-4777-5p	PAR-CLIP	22012620
MIRT530360	hsa-miR-498	PAR-CLIP	22012620
MIRT530359	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT440020	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440018	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT440019	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440017	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT440020	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440018	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT440019	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440017	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT530376	hsa-miR-3156-5p	PAR-CLIP	22012620
MIRT530375	hsa-miR-1179	PAR-CLIP	22012620
MIRT530374	hsa-miR-892c-5p	PAR-CLIP	22012620
MIRT530373	hsa-miR-10b-3p	PAR-CLIP	22012620
MIRT530372	hsa-miR-5100	PAR-CLIP	22012620
MIRT530371	hsa-miR-518d-5p	PAR-CLIP	22012620
MIRT530370	hsa-miR-518e-5p	PAR-CLIP	22012620
MIRT530369	hsa-miR-518f-5p	PAR-CLIP	22012620
MIRT530368	hsa-miR-519a-5p	PAR-CLIP	22012620
MIRT530367	hsa-miR-519b-5p	PAR-CLIP	22012620
MIRT530366	hsa-miR-519c-5p	PAR-CLIP	22012620
MIRT530365	hsa-miR-520c-5p	PAR-CLIP	22012620
MIRT530364	hsa-miR-522-5p	PAR-CLIP	22012620
MIRT530363	hsa-miR-523-5p	PAR-CLIP	22012620
MIRT530362	hsa-miR-526a	PAR-CLIP	22012620
MIRT530361	hsa-miR-4777-5p	PAR-CLIP	22012620
MIRT530360	hsa-miR-498	PAR-CLIP	22012620
MIRT530359	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT1218408	hsa-miR-103a	CLIP-seq
MIRT1218409	hsa-miR-107	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT1218413	hsa-miR-4267	CLIP-seq
MIRT1218414	hsa-miR-4269	CLIP-seq
MIRT1218415	hsa-miR-4423-5p	CLIP-seq
MIRT1218416	hsa-miR-4514	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT1218419	hsa-miR-4692	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT1218422	hsa-miR-508-5p	CLIP-seq
MIRT1218423	hsa-miR-510	CLIP-seq
MIRT1218424	hsa-miR-512-5p	CLIP-seq
MIRT1218425	hsa-miR-543	CLIP-seq
MIRT1218426	hsa-miR-544	CLIP-seq
MIRT1218427	hsa-miR-548ac	CLIP-seq
MIRT1218428	hsa-miR-548ae	CLIP-seq
MIRT1218429	hsa-miR-548aj	CLIP-seq
MIRT1218430	hsa-miR-548am	CLIP-seq
MIRT1218431	hsa-miR-548d-3p	CLIP-seq
MIRT1218432	hsa-miR-548x	CLIP-seq
MIRT1218433	hsa-miR-548z	CLIP-seq
MIRT1218434	hsa-miR-766	CLIP-seq
MIRT1218435	hsa-miR-128	CLIP-seq
MIRT1218436	hsa-miR-140-3p	CLIP-seq
MIRT1218437	hsa-miR-148a	CLIP-seq
MIRT1218438	hsa-miR-148b	CLIP-seq
MIRT1218439	hsa-miR-152	CLIP-seq
MIRT1218440	hsa-miR-338-5p	CLIP-seq
MIRT1218441	hsa-miR-4517	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT1218442	hsa-miR-4733-3p	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT1218443	hsa-miR-4799-5p	CLIP-seq
MIRT1218444	hsa-miR-767-5p	CLIP-seq
MIRT2063199	hsa-miR-105	CLIP-seq
MIRT2063200	hsa-miR-1261	CLIP-seq
MIRT2063201	hsa-miR-3671	CLIP-seq
MIRT2063202	hsa-miR-5096	CLIP-seq
MIRT2063203	hsa-miR-607	CLIP-seq
MIRT2291579	hsa-miR-3125	CLIP-seq
MIRT2291580	hsa-miR-3916	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT2063199	hsa-miR-105	CLIP-seq
MIRT2589174	hsa-miR-1178	CLIP-seq
MIRT2589175	hsa-miR-1237	CLIP-seq
MIRT2589176	hsa-miR-1245	CLIP-seq
MIRT2589177	hsa-miR-1245b-5p	CLIP-seq
MIRT2589178	hsa-miR-1248	CLIP-seq
MIRT2589179	hsa-miR-1252	CLIP-seq
MIRT2589180	hsa-miR-1256	CLIP-seq
MIRT2589181	hsa-miR-125a-3p	CLIP-seq
MIRT2589182	hsa-miR-1264	CLIP-seq
MIRT2589183	hsa-miR-1266	CLIP-seq
MIRT2589184	hsa-miR-1273d	CLIP-seq
MIRT2589185	hsa-miR-1273e	CLIP-seq
MIRT2589186	hsa-miR-1279	CLIP-seq
MIRT1218435	hsa-miR-128	CLIP-seq
MIRT2589187	hsa-miR-1294	CLIP-seq
MIRT2589188	hsa-miR-1295	CLIP-seq
MIRT2589189	hsa-miR-1299	CLIP-seq
MIRT2589190	hsa-miR-1305	CLIP-seq
MIRT2589191	hsa-miR-1321	CLIP-seq
MIRT2589192	hsa-miR-1323	CLIP-seq
MIRT2589193	hsa-miR-1324	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT2589194	hsa-miR-141	CLIP-seq
MIRT2589195	hsa-miR-142-3p	CLIP-seq
MIRT1218437	hsa-miR-148a	CLIP-seq
MIRT1218438	hsa-miR-148b	CLIP-seq
MIRT1218439	hsa-miR-152	CLIP-seq
MIRT2589196	hsa-miR-181a	CLIP-seq
MIRT2589197	hsa-miR-181b	CLIP-seq
MIRT2589198	hsa-miR-181c	CLIP-seq
MIRT2589199	hsa-miR-181d	CLIP-seq
MIRT2589200	hsa-miR-186	CLIP-seq
MIRT2589201	hsa-miR-1912	CLIP-seq
MIRT2589202	hsa-miR-1915	CLIP-seq
MIRT2589203	hsa-miR-200a	CLIP-seq
MIRT2589204	hsa-miR-203	CLIP-seq
MIRT2589205	hsa-miR-205	CLIP-seq
MIRT2589206	hsa-miR-2052	CLIP-seq
MIRT2589207	hsa-miR-2116	CLIP-seq
MIRT2589208	hsa-miR-219-1-3p	CLIP-seq
MIRT2589209	hsa-miR-2276	CLIP-seq
MIRT2589210	hsa-miR-2278	CLIP-seq
MIRT2589211	hsa-miR-23a	CLIP-seq
MIRT2589212	hsa-miR-23b	CLIP-seq
MIRT2589213	hsa-miR-23c	CLIP-seq
MIRT2589214	hsa-miR-2909	CLIP-seq
MIRT2589215	hsa-miR-302f	CLIP-seq
MIRT2589216	hsa-miR-3064-3p	CLIP-seq
MIRT2589217	hsa-miR-3074-5p	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT2589218	hsa-miR-3120-3p	CLIP-seq
MIRT2291579	hsa-miR-3125	CLIP-seq
MIRT2589219	hsa-miR-3127-3p	CLIP-seq
MIRT2589220	hsa-miR-3133	CLIP-seq
MIRT2589221	hsa-miR-3140-3p	CLIP-seq
MIRT2589222	hsa-miR-3142	CLIP-seq
MIRT2589223	hsa-miR-3145-5p	CLIP-seq
MIRT2589224	hsa-miR-3148	CLIP-seq
MIRT2589225	hsa-miR-3152-5p	CLIP-seq
MIRT2589226	hsa-miR-3161	CLIP-seq
MIRT2589227	hsa-miR-3162-5p	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT2589228	hsa-miR-3166	CLIP-seq
MIRT2589229	hsa-miR-3170	CLIP-seq
MIRT2589230	hsa-miR-3185	CLIP-seq
MIRT2589231	hsa-miR-3194-3p	CLIP-seq
MIRT2589232	hsa-miR-3200-5p	CLIP-seq
MIRT2589233	hsa-miR-320a	CLIP-seq
MIRT2589234	hsa-miR-320b	CLIP-seq
MIRT2589235	hsa-miR-320c	CLIP-seq
MIRT2589236	hsa-miR-320d	CLIP-seq
MIRT2589237	hsa-miR-338-3p	CLIP-seq
MIRT1218440	hsa-miR-338-5p	CLIP-seq
MIRT2589238	hsa-miR-340	CLIP-seq
MIRT2589239	hsa-miR-345	CLIP-seq
MIRT2589240	hsa-miR-3529	CLIP-seq
MIRT2589241	hsa-miR-3545-3p	CLIP-seq
MIRT2589242	hsa-miR-3606	CLIP-seq
MIRT2589243	hsa-miR-3607-3p	CLIP-seq
MIRT2589244	hsa-miR-3613-3p	CLIP-seq
MIRT2589245	hsa-miR-3614-5p	CLIP-seq
MIRT2589246	hsa-miR-3646	CLIP-seq
MIRT2589247	hsa-miR-3647-3p	CLIP-seq
MIRT2589248	hsa-miR-3652	CLIP-seq
MIRT2589249	hsa-miR-3664-3p	CLIP-seq
MIRT2589250	hsa-miR-3665	CLIP-seq
MIRT2589251	hsa-miR-3670	CLIP-seq
MIRT2063201	hsa-miR-3671	CLIP-seq
MIRT2589252	hsa-miR-3673	CLIP-seq
MIRT2589253	hsa-miR-3678-3p	CLIP-seq
MIRT2589254	hsa-miR-3688-3p	CLIP-seq
MIRT2589255	hsa-miR-370	CLIP-seq
MIRT2589256	hsa-miR-371-5p	CLIP-seq
MIRT2589257	hsa-miR-379	CLIP-seq
MIRT2291580	hsa-miR-3916	CLIP-seq
MIRT2589258	hsa-miR-3928	CLIP-seq
MIRT2589259	hsa-miR-3944-5p	CLIP-seq
MIRT2589260	hsa-miR-3978	CLIP-seq
MIRT2589261	hsa-miR-4255	CLIP-seq
MIRT2589262	hsa-miR-4256	CLIP-seq
MIRT2589263	hsa-miR-4261	CLIP-seq
MIRT2589264	hsa-miR-4262	CLIP-seq
MIRT2589265	hsa-miR-4266	CLIP-seq
MIRT1218413	hsa-miR-4267	CLIP-seq
MIRT1218414	hsa-miR-4269	CLIP-seq
MIRT2589266	hsa-miR-4280	CLIP-seq
MIRT2589267	hsa-miR-4282	CLIP-seq
MIRT2589268	hsa-miR-4307	CLIP-seq
MIRT2589269	hsa-miR-4310	CLIP-seq
MIRT2589270	hsa-miR-433	CLIP-seq
MIRT2589271	hsa-miR-4422	CLIP-seq
MIRT1218415	hsa-miR-4423-5p	CLIP-seq
MIRT2589272	hsa-miR-4426	CLIP-seq
MIRT2589273	hsa-miR-4427	CLIP-seq
MIRT2589274	hsa-miR-4429	CLIP-seq
MIRT2589275	hsa-miR-4430	CLIP-seq
MIRT2589276	hsa-miR-4437	CLIP-seq
MIRT2589277	hsa-miR-4451	CLIP-seq
MIRT2589278	hsa-miR-4461	CLIP-seq
MIRT2589279	hsa-miR-4481	CLIP-seq
MIRT2589280	hsa-miR-4501	CLIP-seq
MIRT2589281	hsa-miR-4505	CLIP-seq
MIRT1218416	hsa-miR-4514	CLIP-seq
MIRT1218441	hsa-miR-4517	CLIP-seq
MIRT2589282	hsa-miR-4518	CLIP-seq
MIRT2589283	hsa-miR-452	CLIP-seq
MIRT2589284	hsa-miR-4642	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT2589285	hsa-miR-4647	CLIP-seq
MIRT2589286	hsa-miR-4650-3p	CLIP-seq
MIRT2589287	hsa-miR-4652-3p	CLIP-seq
MIRT2589288	hsa-miR-4659a-5p	CLIP-seq
MIRT2589289	hsa-miR-4659b-5p	CLIP-seq
MIRT2589290	hsa-miR-4662b	CLIP-seq
MIRT2589291	hsa-miR-4670-3p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT2589292	hsa-miR-4674	CLIP-seq
MIRT2589293	hsa-miR-4676-3p	CLIP-seq
MIRT2589294	hsa-miR-4677-5p	CLIP-seq
MIRT2589295	hsa-miR-4680-3p	CLIP-seq
MIRT2589296	hsa-miR-4680-5p	CLIP-seq
MIRT2589297	hsa-miR-4684-5p	CLIP-seq
MIRT1218419	hsa-miR-4692	CLIP-seq
MIRT2589298	hsa-miR-4693-3p	CLIP-seq
MIRT2589299	hsa-miR-4698	CLIP-seq
MIRT2589300	hsa-miR-4700-3p	CLIP-seq
MIRT2589301	hsa-miR-4709-3p	CLIP-seq
MIRT2589302	hsa-miR-4710	CLIP-seq
MIRT2589303	hsa-miR-4715-5p	CLIP-seq
MIRT2589304	hsa-miR-4717-3p	CLIP-seq
MIRT2589305	hsa-miR-4719	CLIP-seq
MIRT2589306	hsa-miR-4722-3p	CLIP-seq
MIRT2589307	hsa-miR-4724-3p	CLIP-seq
MIRT2589308	hsa-miR-4726-3p	CLIP-seq
MIRT2589309	hsa-miR-4731-3p	CLIP-seq
MIRT2589310	hsa-miR-4731-5p	CLIP-seq
MIRT1218442	hsa-miR-4733-3p	CLIP-seq
MIRT2589311	hsa-miR-4733-5p	CLIP-seq
MIRT2589312	hsa-miR-4738-3p	CLIP-seq
MIRT2589313	hsa-miR-4739	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT2589314	hsa-miR-4745-5p	CLIP-seq
MIRT2589315	hsa-miR-4756-5p	CLIP-seq
MIRT2589316	hsa-miR-4760-3p	CLIP-seq
MIRT2589317	hsa-miR-4762-3p	CLIP-seq
MIRT2589318	hsa-miR-4765	CLIP-seq
MIRT2589319	hsa-miR-4771	CLIP-seq
MIRT2589320	hsa-miR-4772-3p	CLIP-seq
MIRT2589321	hsa-miR-4774-3p	CLIP-seq
MIRT2589322	hsa-miR-4776-3p	CLIP-seq
MIRT2589323	hsa-miR-4778-5p	CLIP-seq
MIRT2589324	hsa-miR-4782-5p	CLIP-seq
MIRT2589325	hsa-miR-4786-3p	CLIP-seq
MIRT2589326	hsa-miR-4795-3p	CLIP-seq
MIRT2589327	hsa-miR-4797-5p	CLIP-seq
MIRT1218443	hsa-miR-4799-5p	CLIP-seq
MIRT2589328	hsa-miR-4801	CLIP-seq
MIRT2589329	hsa-miR-4802-3p	CLIP-seq
MIRT2589330	hsa-miR-490-5p	CLIP-seq
MIRT2589331	hsa-miR-494	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT1218422	hsa-miR-508-5p	CLIP-seq
MIRT1218423	hsa-miR-510	CLIP-seq
MIRT1218424	hsa-miR-512-5p	CLIP-seq
MIRT2589332	hsa-miR-516b	CLIP-seq
MIRT2589333	hsa-miR-518a-5p	CLIP-seq
MIRT2589334	hsa-miR-522	CLIP-seq
MIRT2589335	hsa-miR-526b	CLIP-seq
MIRT2589336	hsa-miR-527	CLIP-seq
MIRT2589337	hsa-miR-532-5p	CLIP-seq
MIRT1218425	hsa-miR-543	CLIP-seq
MIRT2589338	hsa-miR-545	CLIP-seq
MIRT2589339	hsa-miR-548a-3p	CLIP-seq
MIRT2589340	hsa-miR-548b-3p	CLIP-seq
MIRT2589341	hsa-miR-548e	CLIP-seq
MIRT2589342	hsa-miR-548f	CLIP-seq
MIRT2589343	hsa-miR-548g	CLIP-seq
MIRT2589344	hsa-miR-548o	CLIP-seq
MIRT2589345	hsa-miR-548v	CLIP-seq
MIRT2589346	hsa-miR-571	CLIP-seq
MIRT2589347	hsa-miR-576-3p	CLIP-seq
MIRT2589348	hsa-miR-576-5p	CLIP-seq
MIRT2589349	hsa-miR-578	CLIP-seq
MIRT2589350	hsa-miR-580	CLIP-seq
MIRT2589351	hsa-miR-582-5p	CLIP-seq
MIRT2589352	hsa-miR-600	CLIP-seq
MIRT2063203	hsa-miR-607	CLIP-seq
MIRT2589353	hsa-miR-627	CLIP-seq
MIRT2589354	hsa-miR-647	CLIP-seq
MIRT2589355	hsa-miR-651	CLIP-seq
MIRT2589356	hsa-miR-656	CLIP-seq
MIRT2589357	hsa-miR-659	CLIP-seq
MIRT2589358	hsa-miR-671-5p	CLIP-seq
MIRT2589359	hsa-miR-759	CLIP-seq
MIRT1218434	hsa-miR-766	CLIP-seq
MIRT1218444	hsa-miR-767-5p	CLIP-seq
MIRT2589360	hsa-miR-873	CLIP-seq
MIRT2589361	hsa-miR-875-3p	CLIP-seq
MIRT2589362	hsa-miR-889	CLIP-seq
MIRT2589363	hsa-miR-921	CLIP-seq
MIRT2589364	hsa-miR-924	CLIP-seq
MIRT2589365	hsa-miR-944	CLIP-seq
MIRT2063199	hsa-miR-105	CLIP-seq
MIRT2589174	hsa-miR-1178	CLIP-seq
MIRT2589175	hsa-miR-1237	CLIP-seq
MIRT2589176	hsa-miR-1245	CLIP-seq
MIRT2589177	hsa-miR-1245b-5p	CLIP-seq
MIRT2589178	hsa-miR-1248	CLIP-seq
MIRT2589179	hsa-miR-1252	CLIP-seq
MIRT2589180	hsa-miR-1256	CLIP-seq
MIRT2589181	hsa-miR-125a-3p	CLIP-seq
MIRT2687274	hsa-miR-1262	CLIP-seq
MIRT2589182	hsa-miR-1264	CLIP-seq
MIRT2589183	hsa-miR-1266	CLIP-seq
MIRT2589184	hsa-miR-1273d	CLIP-seq
MIRT2589185	hsa-miR-1273e	CLIP-seq
MIRT2589186	hsa-miR-1279	CLIP-seq
MIRT1218435	hsa-miR-128	CLIP-seq
MIRT2589187	hsa-miR-1294	CLIP-seq
MIRT2589188	hsa-miR-1295	CLIP-seq
MIRT2589189	hsa-miR-1299	CLIP-seq
MIRT2589190	hsa-miR-1305	CLIP-seq
MIRT2589191	hsa-miR-1321	CLIP-seq
MIRT2589192	hsa-miR-1323	CLIP-seq
MIRT2589193	hsa-miR-1324	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT2589194	hsa-miR-141	CLIP-seq
MIRT2589195	hsa-miR-142-3p	CLIP-seq
MIRT1218437	hsa-miR-148a	CLIP-seq
MIRT1218438	hsa-miR-148b	CLIP-seq
MIRT1218439	hsa-miR-152	CLIP-seq
MIRT2589196	hsa-miR-181a	CLIP-seq
MIRT2589197	hsa-miR-181b	CLIP-seq
MIRT2589198	hsa-miR-181c	CLIP-seq
MIRT2589199	hsa-miR-181d	CLIP-seq
MIRT2589200	hsa-miR-186	CLIP-seq
MIRT2589202	hsa-miR-1915	CLIP-seq
MIRT2589203	hsa-miR-200a	CLIP-seq
MIRT2589204	hsa-miR-203	CLIP-seq
MIRT2589205	hsa-miR-205	CLIP-seq
MIRT2589206	hsa-miR-2052	CLIP-seq
MIRT2589207	hsa-miR-2116	CLIP-seq
MIRT2589208	hsa-miR-219-1-3p	CLIP-seq
MIRT2589209	hsa-miR-2276	CLIP-seq
MIRT2589211	hsa-miR-23a	CLIP-seq
MIRT2589212	hsa-miR-23b	CLIP-seq
MIRT2589213	hsa-miR-23c	CLIP-seq
MIRT2589214	hsa-miR-2909	CLIP-seq
MIRT2589215	hsa-miR-302f	CLIP-seq
MIRT2589216	hsa-miR-3064-3p	CLIP-seq
MIRT2589217	hsa-miR-3074-5p	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT2589218	hsa-miR-3120-3p	CLIP-seq
MIRT2291579	hsa-miR-3125	CLIP-seq
MIRT2589219	hsa-miR-3127-3p	CLIP-seq
MIRT2589220	hsa-miR-3133	CLIP-seq
MIRT2589221	hsa-miR-3140-3p	CLIP-seq
MIRT2589222	hsa-miR-3142	CLIP-seq
MIRT2589223	hsa-miR-3145-5p	CLIP-seq
MIRT2589224	hsa-miR-3148	CLIP-seq
MIRT2589225	hsa-miR-3152-5p	CLIP-seq
MIRT2589226	hsa-miR-3161	CLIP-seq
MIRT2589227	hsa-miR-3162-5p	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT2589228	hsa-miR-3166	CLIP-seq
MIRT2589229	hsa-miR-3170	CLIP-seq
MIRT2589230	hsa-miR-3185	CLIP-seq
MIRT2589231	hsa-miR-3194-3p	CLIP-seq
MIRT2589232	hsa-miR-3200-5p	CLIP-seq
MIRT2589233	hsa-miR-320a	CLIP-seq
MIRT2589234	hsa-miR-320b	CLIP-seq
MIRT2589235	hsa-miR-320c	CLIP-seq
MIRT2589236	hsa-miR-320d	CLIP-seq
MIRT2589237	hsa-miR-338-3p	CLIP-seq
MIRT1218440	hsa-miR-338-5p	CLIP-seq
MIRT2589240	hsa-miR-3529	CLIP-seq
MIRT2589241	hsa-miR-3545-3p	CLIP-seq
MIRT2589242	hsa-miR-3606	CLIP-seq
MIRT2589244	hsa-miR-3613-3p	CLIP-seq
MIRT2589245	hsa-miR-3614-5p	CLIP-seq
MIRT2589246	hsa-miR-3646	CLIP-seq
MIRT2589247	hsa-miR-3647-3p	CLIP-seq
MIRT2589248	hsa-miR-3652	CLIP-seq
MIRT2589249	hsa-miR-3664-3p	CLIP-seq
MIRT2589251	hsa-miR-3670	CLIP-seq
MIRT2063201	hsa-miR-3671	CLIP-seq
MIRT2589252	hsa-miR-3673	CLIP-seq
MIRT2589253	hsa-miR-3678-3p	CLIP-seq
MIRT2589254	hsa-miR-3688-3p	CLIP-seq
MIRT2589255	hsa-miR-370	CLIP-seq
MIRT2589256	hsa-miR-371-5p	CLIP-seq
MIRT2589257	hsa-miR-379	CLIP-seq
MIRT2291580	hsa-miR-3916	CLIP-seq
MIRT2589258	hsa-miR-3928	CLIP-seq
MIRT2589259	hsa-miR-3944-5p	CLIP-seq
MIRT2589260	hsa-miR-3978	CLIP-seq
MIRT2589261	hsa-miR-4255	CLIP-seq
MIRT2589263	hsa-miR-4261	CLIP-seq
MIRT2589264	hsa-miR-4262	CLIP-seq
MIRT2589265	hsa-miR-4266	CLIP-seq
MIRT1218413	hsa-miR-4267	CLIP-seq
MIRT1218414	hsa-miR-4269	CLIP-seq
MIRT2589266	hsa-miR-4280	CLIP-seq
MIRT2589267	hsa-miR-4282	CLIP-seq
MIRT2589268	hsa-miR-4307	CLIP-seq
MIRT2589269	hsa-miR-4310	CLIP-seq
MIRT2589270	hsa-miR-433	CLIP-seq
MIRT2589271	hsa-miR-4422	CLIP-seq
MIRT1218415	hsa-miR-4423-5p	CLIP-seq
MIRT2589272	hsa-miR-4426	CLIP-seq
MIRT2589273	hsa-miR-4427	CLIP-seq
MIRT2589274	hsa-miR-4429	CLIP-seq
MIRT2589275	hsa-miR-4430	CLIP-seq
MIRT2589276	hsa-miR-4437	CLIP-seq
MIRT2589277	hsa-miR-4451	CLIP-seq
MIRT2589278	hsa-miR-4461	CLIP-seq
MIRT2589280	hsa-miR-4501	CLIP-seq
MIRT2589281	hsa-miR-4505	CLIP-seq
MIRT1218416	hsa-miR-4514	CLIP-seq
MIRT1218441	hsa-miR-4517	CLIP-seq
MIRT2589282	hsa-miR-4518	CLIP-seq
MIRT2589283	hsa-miR-452	CLIP-seq
MIRT2589284	hsa-miR-4642	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT2589285	hsa-miR-4647	CLIP-seq
MIRT2589286	hsa-miR-4650-3p	CLIP-seq
MIRT2589287	hsa-miR-4652-3p	CLIP-seq
MIRT2589288	hsa-miR-4659a-5p	CLIP-seq
MIRT2589289	hsa-miR-4659b-5p	CLIP-seq
MIRT2589290	hsa-miR-4662b	CLIP-seq
MIRT2589291	hsa-miR-4670-3p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT2589292	hsa-miR-4674	CLIP-seq
MIRT2589293	hsa-miR-4676-3p	CLIP-seq
MIRT2589294	hsa-miR-4677-5p	CLIP-seq
MIRT2589295	hsa-miR-4680-3p	CLIP-seq
MIRT2589296	hsa-miR-4680-5p	CLIP-seq
MIRT2589297	hsa-miR-4684-5p	CLIP-seq
MIRT1218419	hsa-miR-4692	CLIP-seq
MIRT2589298	hsa-miR-4693-3p	CLIP-seq
MIRT2589299	hsa-miR-4698	CLIP-seq
MIRT2589300	hsa-miR-4700-3p	CLIP-seq
MIRT2687275	hsa-miR-4701-3p	CLIP-seq
MIRT2589301	hsa-miR-4709-3p	CLIP-seq
MIRT2589302	hsa-miR-4710	CLIP-seq
MIRT2589303	hsa-miR-4715-5p	CLIP-seq
MIRT2589304	hsa-miR-4717-3p	CLIP-seq
MIRT2589305	hsa-miR-4719	CLIP-seq
MIRT2589307	hsa-miR-4724-3p	CLIP-seq
MIRT2589308	hsa-miR-4726-3p	CLIP-seq
MIRT2589309	hsa-miR-4731-3p	CLIP-seq
MIRT2589310	hsa-miR-4731-5p	CLIP-seq
MIRT1218442	hsa-miR-4733-3p	CLIP-seq
MIRT2589311	hsa-miR-4733-5p	CLIP-seq
MIRT2589312	hsa-miR-4738-3p	CLIP-seq
MIRT2589313	hsa-miR-4739	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT2589315	hsa-miR-4756-5p	CLIP-seq
MIRT2589316	hsa-miR-4760-3p	CLIP-seq
MIRT2589318	hsa-miR-4765	CLIP-seq
MIRT2589319	hsa-miR-4771	CLIP-seq
MIRT2589320	hsa-miR-4772-3p	CLIP-seq
MIRT2589321	hsa-miR-4774-3p	CLIP-seq
MIRT2589322	hsa-miR-4776-3p	CLIP-seq
MIRT2589323	hsa-miR-4778-5p	CLIP-seq
MIRT2589324	hsa-miR-4782-5p	CLIP-seq
MIRT2589325	hsa-miR-4786-3p	CLIP-seq
MIRT2589326	hsa-miR-4795-3p	CLIP-seq
MIRT2589327	hsa-miR-4797-5p	CLIP-seq
MIRT1218443	hsa-miR-4799-5p	CLIP-seq
MIRT2589328	hsa-miR-4801	CLIP-seq
MIRT2589329	hsa-miR-4802-3p	CLIP-seq
MIRT2589330	hsa-miR-490-5p	CLIP-seq
MIRT2589331	hsa-miR-494	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT1218422	hsa-miR-508-5p	CLIP-seq
MIRT1218423	hsa-miR-510	CLIP-seq
MIRT1218424	hsa-miR-512-5p	CLIP-seq
MIRT2589332	hsa-miR-516b	CLIP-seq
MIRT2589333	hsa-miR-518a-5p	CLIP-seq
MIRT2589334	hsa-miR-522	CLIP-seq
MIRT2589335	hsa-miR-526b	CLIP-seq
MIRT2589336	hsa-miR-527	CLIP-seq
MIRT2589337	hsa-miR-532-5p	CLIP-seq
MIRT1218425	hsa-miR-543	CLIP-seq
MIRT2589338	hsa-miR-545	CLIP-seq
MIRT2589339	hsa-miR-548a-3p	CLIP-seq
MIRT1218427	hsa-miR-548ac	CLIP-seq
MIRT1218428	hsa-miR-548ae	CLIP-seq
MIRT1218429	hsa-miR-548aj	CLIP-seq
MIRT1218430	hsa-miR-548am	CLIP-seq
MIRT2589340	hsa-miR-548b-3p	CLIP-seq
MIRT1218431	hsa-miR-548d-3p	CLIP-seq
MIRT2589341	hsa-miR-548e	CLIP-seq
MIRT2589342	hsa-miR-548f	CLIP-seq
MIRT2589343	hsa-miR-548g	CLIP-seq
MIRT2589344	hsa-miR-548o	CLIP-seq
MIRT2589345	hsa-miR-548v	CLIP-seq
MIRT1218432	hsa-miR-548x	CLIP-seq
MIRT1218433	hsa-miR-548z	CLIP-seq
MIRT2589346	hsa-miR-571	CLIP-seq
MIRT2589347	hsa-miR-576-3p	CLIP-seq
MIRT2589348	hsa-miR-576-5p	CLIP-seq
MIRT2589349	hsa-miR-578	CLIP-seq
MIRT2589350	hsa-miR-580	CLIP-seq
MIRT2589351	hsa-miR-582-5p	CLIP-seq
MIRT2589352	hsa-miR-600	CLIP-seq
MIRT2063203	hsa-miR-607	CLIP-seq
MIRT2589353	hsa-miR-627	CLIP-seq
MIRT2589354	hsa-miR-647	CLIP-seq
MIRT2589355	hsa-miR-651	CLIP-seq
MIRT2589356	hsa-miR-656	CLIP-seq
MIRT2589357	hsa-miR-659	CLIP-seq
MIRT2589358	hsa-miR-671-5p	CLIP-seq
MIRT2589359	hsa-miR-759	CLIP-seq
MIRT1218434	hsa-miR-766	CLIP-seq
MIRT1218444	hsa-miR-767-5p	CLIP-seq
MIRT2589360	hsa-miR-873	CLIP-seq
MIRT2589361	hsa-miR-875-3p	CLIP-seq
MIRT2589362	hsa-miR-889	CLIP-seq
MIRT2589363	hsa-miR-921	CLIP-seq
MIRT2589364	hsa-miR-924	CLIP-seq
MIRT2589365	hsa-miR-944	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF1	Activation	8999965
CREB1	Activation	8999965
PAX6	Activation	19034419
REST	Unknown	19118055

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	ISS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	8397508
GO:0006508	Process	Proteolysis	TAS	9207799
GO:0007267	Process	Cell-cell signaling	TAS	9207799
GO:0016020	Component	Membrane	IBA	21873635
GO:0016485	Process	Protein processing	IBA	21873635
GO:0016486	Process	Peptide hormone processing	IBA	21873635
GO:0016486	Process	Peptide hormone processing	TAS
GO:0030133	Component	Transport vesicle	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043043	Process	Peptide biosynthetic process	ISS

Other IDs

• MIM: 162150
• HGNC: 8743
• e!Ensembl: ENSG00000175426

Protein

• UniProt ID: P29120
• Protein name: Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1)
• Protein function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16470	S8_pro-domain	34 → 110	Peptidase S8 pro-domain	Domain
  PF00082	Peptidase_S8	158 → 442	Subtilase family	Domain
  PF01483	P_proprotein	504 → 591	Proprotein convertase P-domain	Family
  PF12177	Proho_convert	713 → 751	Prohormone convertase enzyme	Domain

• Sequence:

  MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQ
  IGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL
  FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYAN
  YDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM
  LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKG
  SIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY
  TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPL
  ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK
  ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERE
  RDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH
  MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEE
  GAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL
  YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN

• Sequence length: 753

Pathways

Reactome:

Peptide hormone biosynthesis
Synthesis, secretion, and deacylation of Ghrelin

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cholestasis	Cholestasis	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039
Hyperinsulinism	Hyperinsulinism	rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Isolated somatotropin deficiency	Isolated somatotropin deficiency	rs797044450, rs71640277, rs863223306, rs2144738731, rs863223307, rs2144739370, rs863223309, rs863223310, rs137853223, rs2144739380, rs2144739391
Obesity	Obesity, Obesity due to prohormone convertase I deficiency	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	18604207
Adrenal insufficiency	Secondary Adrenal Insufficiency	rs104894118, rs104894119
Hypothyroidism	Secondary hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605

Unknown
Disease name	Disease term	dbSNP ID	References
Acanthosis nigricans	Acanthosis Nigricans	rs780668
Gonadotropin deficiency	Gonadotropin deficiency
Hypoglycemic seizures	Hypoglycemic seizures
Hypogonadism	Hypogonadism
Hypopigmentation disorder	Hypopigmentation disorder
Malabsorption syndrome	Malabsorption Syndrome
Physiologic amenorrhea	Primary physiologic amenorrhea
Proprotein convertase 1/3 deficiency	Proprotein Convertase 1 3 Deficiency		9207799, 17595246, 14617756
Reactive hypoglycemia	Reactive hypoglycemia
Somatotropin deficiency	Somatotropin deficiency