DCXR (dicarbonyl and L-xylulose reductase)

Gene

• Entrez ID: 51181
• Gene name: Dicarbonyl and L-xylulose reductase
• Gene symbol: DCXR
• Synonyms: DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal re

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037386	hsa-miR-744-5p	CLASH	23622248
MIRT928393	hsa-miR-1255b	CLIP-seq
MIRT928394	hsa-miR-3622b-5p	CLIP-seq
MIRT928395	hsa-miR-3675-5p	CLIP-seq
MIRT928396	hsa-miR-4283	CLIP-seq
MIRT928397	hsa-miR-4304	CLIP-seq
MIRT928398	hsa-miR-4489	CLIP-seq
MIRT928393	hsa-miR-1255b	CLIP-seq
MIRT928394	hsa-miR-3622b-5p	CLIP-seq
MIRT928395	hsa-miR-3675-5p	CLIP-seq
MIRT928397	hsa-miR-4304	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005881	Component	Cytoplasmic microtubule	IDA	23264731
GO:0005886	Component	Plasma membrane	TAS
GO:0005902	Component	Microvillus	IEA
GO:0005903	Component	Brush border	IEA
GO:0005997	Process	Xylulose metabolic process	IBA	21873635
GO:0005997	Process	Xylulose metabolic process	IDA	11882650
GO:0006006	Process	Glucose metabolic process	IBA	21873635
GO:0006006	Process	Glucose metabolic process	IDA	11882650
GO:0006739	Process	NADP metabolic process	IEA
GO:0016655	Function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656
GO:0019640	Process	Glucuronate catabolic process to xylulose 5-phosphate	TAS
GO:0042732	Process	D-xylose metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 31515488, 32296183
GO:0044105	Function	L-xylulose reductase (NAD+) activity	IEA
GO:0050038	Function	L-xylulose reductase (NADP+) activity	IBA	21873635
GO:0050038	Function	L-xylulose reductase (NADP+) activity	IDA	11882650
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 608347
• HGNC: 18985
• e!Ensembl: ENSG00000169738

Protein

• UniProt ID: Q7Z4W1
• Protein name: L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H)
• Protein function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulati
• PDB: 1PR9, 1WNT, 3D3W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13561	adh_short_C2	14 → 242		Domain

• Sequence:

  MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD
  LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR
  GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT
  VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG
  FWAC

• Sequence length: 244

Pathways

KEGG:

Pentose and glucuronate interconversions
Metabolic pathways

Reactome:

Formation of xylulose-5-phosphate
Essential pentosuria

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	20882379
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Pentosuria	Pentosuria		25526675, 28595002, 22042873, 23988570
Prostatic neoplasms	Prostatic Neoplasms		17013881