IRAK4 (interleukin 1 receptor associated kinase 4)

Gene

• Entrez ID: 51135
• Gene name: Interleukin 1 receptor associated kinase 4
• Gene symbol: IRAK4
• Synonyms: IMD67, IPD1, IRAK-4, NY-REN-64, REN64
• Chromosome: 12
• Chromosome location: 12q12
• Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurre

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs114951157	C>T	Pathogenic	Coding sequence variant, stop gained, synonymous variant
rs121908002	C>T	Pathogenic	Coding sequence variant, stop gained, genic downstream transcript variant
rs377584435	C>T	Likely-pathogenic, pathogenic	Intron variant, missense variant, coding sequence variant, 5 prime UTR variant
rs758539498	G>A,T	Pathogenic	Genic downstream transcript variant, intron variant
rs944235493	A>G	Pathogenic	Genic downstream transcript variant, intron variant
rs1443126481	G>C,T	Pathogenic	5 prime UTR variant, stop gained, intron variant, coding sequence variant, missense variant
rs1555167566	G>-	Pathogenic	Frameshift variant, 5 prime UTR variant, coding sequence variant, intron variant
rs1555169270	G>T	Likely-pathogenic	Genic downstream transcript variant, splice acceptor variant
rs1565678077	T>-	Pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs1565688667	G>T	Pathogenic	Genic downstream transcript variant, splice acceptor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024734	hsa-miR-215-5p	Microarray	19074876
MIRT026168	hsa-miR-192-5p	Microarray	19074876
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT690758	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT690757	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT690756	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT690755	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT690754	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT690753	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT690752	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT690751	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT690750	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT690749	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT690748	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT690747	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT690746	hsa-miR-302e	HITS-CLIP	23313552
MIRT690745	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT690744	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT690743	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT690742	hsa-miR-520b	HITS-CLIP	23313552
MIRT690741	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT690740	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT690739	hsa-miR-520e	HITS-CLIP	23313552
MIRT690738	hsa-miR-552-3p	HITS-CLIP	23313552
MIRT690737	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT690736	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690735	hsa-miR-520h	HITS-CLIP	23313552
MIRT690734	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT690732	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT690733	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT690731	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT690730	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT690728	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT690729	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT690727	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT690726	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT690725	hsa-miR-5095	HITS-CLIP	23313552
MIRT690724	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT690723	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661893	hsa-miR-7162-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT629367	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629366	hsa-miR-4308	HITS-CLIP	23824327
MIRT629365	hsa-miR-4292	HITS-CLIP	23824327
MIRT629364	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT629363	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629362	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT629361	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT629360	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT629359	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT629358	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT508612	hsa-miR-940	PAR-CLIP	20371350
MIRT515031	hsa-miR-3929	PAR-CLIP	20371350
MIRT515030	hsa-miR-4419b	PAR-CLIP	20371350
MIRT515029	hsa-miR-4478	PAR-CLIP	20371350
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT508608	hsa-miR-1827	PAR-CLIP	20371350
MIRT515028	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT515025	hsa-miR-665	PAR-CLIP	20371350
MIRT508615	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	21572407
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT508612	hsa-miR-940	PAR-CLIP	21572407
MIRT515031	hsa-miR-3929	PAR-CLIP	21572407
MIRT515030	hsa-miR-4419b	PAR-CLIP	21572407
MIRT515029	hsa-miR-4478	PAR-CLIP	21572407
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT508608	hsa-miR-1827	PAR-CLIP	21572407
MIRT515028	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	21572407
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	21572407
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT515025	hsa-miR-665	PAR-CLIP	21572407
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT515031	hsa-miR-3929	PAR-CLIP	23446348
MIRT515030	hsa-miR-4419b	PAR-CLIP	23446348
MIRT515029	hsa-miR-4478	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT515028	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT515025	hsa-miR-665	PAR-CLIP	23446348
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT735379	hsa-miR-146a-5p	qRT-PCR	31739406
MIRT736351	hsa-miR-378a-3p	Luciferase reporter assay, Western blotting, Microarray, qRT-PCR, GFP reporter assay	33261009
MIRT690758	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT690757	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT690756	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT690755	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT690754	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT690753	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT690752	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT690751	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT690750	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT690749	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT690748	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT690747	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT690746	hsa-miR-302e	HITS-CLIP	23313552
MIRT690745	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT690744	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT690743	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT690742	hsa-miR-520b	HITS-CLIP	23313552
MIRT690741	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT690740	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT690739	hsa-miR-520e	HITS-CLIP	23313552
MIRT690738	hsa-miR-552-3p	HITS-CLIP	23313552
MIRT690737	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT690736	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690735	hsa-miR-520h	HITS-CLIP	23313552
MIRT690734	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT690732	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT690733	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT690731	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT690730	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT690728	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT690729	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT690727	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT690726	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT690725	hsa-miR-5095	HITS-CLIP	23313552
MIRT690724	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT690723	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661893	hsa-miR-7162-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT629367	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629366	hsa-miR-4308	HITS-CLIP	23824327
MIRT629365	hsa-miR-4292	HITS-CLIP	23824327
MIRT629364	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT629363	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629362	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT629361	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT629360	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT629359	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT629358	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT508612	hsa-miR-940	PAR-CLIP	20371350
MIRT515031	hsa-miR-3929	PAR-CLIP	20371350
MIRT515030	hsa-miR-4419b	PAR-CLIP	20371350
MIRT515029	hsa-miR-4478	PAR-CLIP	20371350
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT508608	hsa-miR-1827	PAR-CLIP	20371350
MIRT515028	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT515025	hsa-miR-665	PAR-CLIP	20371350
MIRT508615	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	21572407
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT508612	hsa-miR-940	PAR-CLIP	21572407
MIRT515031	hsa-miR-3929	PAR-CLIP	21572407
MIRT515030	hsa-miR-4419b	PAR-CLIP	21572407
MIRT515029	hsa-miR-4478	PAR-CLIP	21572407
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT508608	hsa-miR-1827	PAR-CLIP	21572407
MIRT515028	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	21572407
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	21572407
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT515025	hsa-miR-665	PAR-CLIP	21572407
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT515031	hsa-miR-3929	PAR-CLIP	23446348
MIRT515030	hsa-miR-4419b	PAR-CLIP	23446348
MIRT515029	hsa-miR-4478	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT515028	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT515025	hsa-miR-665	PAR-CLIP	23446348
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT1070560	hsa-miR-1271	CLIP-seq
MIRT1070561	hsa-miR-1272	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT1070563	hsa-miR-1322	CLIP-seq
MIRT1070564	hsa-miR-182	CLIP-seq
MIRT1070565	hsa-miR-1909	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT1070567	hsa-miR-3134	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT1070572	hsa-miR-320e	CLIP-seq
MIRT1070573	hsa-miR-345	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT1070575	hsa-miR-3664-5p	CLIP-seq
MIRT1070576	hsa-miR-4263	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070579	hsa-miR-4330	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT1070581	hsa-miR-4534	CLIP-seq
MIRT1070582	hsa-miR-4639-3p	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT1070586	hsa-miR-4735-5p	CLIP-seq
MIRT1070587	hsa-miR-4775	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT1070589	hsa-miR-590-3p	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT1070591	hsa-miR-96	CLIP-seq
MIRT1070592	hsa-miR-106a	CLIP-seq
MIRT1070593	hsa-miR-106b	CLIP-seq
MIRT1070594	hsa-miR-1184	CLIP-seq
MIRT1070595	hsa-miR-1205	CLIP-seq
MIRT1070596	hsa-miR-1234	CLIP-seq
MIRT1070597	hsa-miR-1252	CLIP-seq
MIRT1070561	hsa-miR-1272	CLIP-seq
MIRT1070598	hsa-miR-1273g	CLIP-seq
MIRT1070599	hsa-miR-127-5p	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT1070563	hsa-miR-1322	CLIP-seq
MIRT1070600	hsa-miR-150	CLIP-seq
MIRT1070601	hsa-miR-17	CLIP-seq
MIRT1070602	hsa-miR-1972	CLIP-seq
MIRT1070603	hsa-miR-20a	CLIP-seq
MIRT1070604	hsa-miR-20b	CLIP-seq
MIRT1070605	hsa-miR-302a	CLIP-seq
MIRT1070606	hsa-miR-302b	CLIP-seq
MIRT1070607	hsa-miR-302c	CLIP-seq
MIRT1070608	hsa-miR-302d	CLIP-seq
MIRT1070567	hsa-miR-3134	CLIP-seq
MIRT1070609	hsa-miR-3158-5p	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT1070575	hsa-miR-3664-5p	CLIP-seq
MIRT1070610	hsa-miR-372	CLIP-seq
MIRT1070611	hsa-miR-373	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070612	hsa-miR-432	CLIP-seq
MIRT1070613	hsa-miR-4428	CLIP-seq
MIRT1070614	hsa-miR-4453	CLIP-seq
MIRT1070581	hsa-miR-4534	CLIP-seq
MIRT1070615	hsa-miR-4538	CLIP-seq
MIRT1070582	hsa-miR-4639-3p	CLIP-seq
MIRT1070616	hsa-miR-519d	CLIP-seq
MIRT1070617	hsa-miR-520g	CLIP-seq
MIRT1070618	hsa-miR-544	CLIP-seq
MIRT1070619	hsa-miR-552	CLIP-seq
MIRT1070620	hsa-miR-93	CLIP-seq
MIRT1070592	hsa-miR-106a	CLIP-seq
MIRT1070593	hsa-miR-106b	CLIP-seq
MIRT1070594	hsa-miR-1184	CLIP-seq
MIRT1070595	hsa-miR-1205	CLIP-seq
MIRT1070596	hsa-miR-1234	CLIP-seq
MIRT1070600	hsa-miR-150	CLIP-seq
MIRT1070601	hsa-miR-17	CLIP-seq
MIRT1070565	hsa-miR-1909	CLIP-seq
MIRT1070602	hsa-miR-1972	CLIP-seq
MIRT1070603	hsa-miR-20a	CLIP-seq
MIRT1070604	hsa-miR-20b	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT1070605	hsa-miR-302a	CLIP-seq
MIRT1070606	hsa-miR-302b	CLIP-seq
MIRT1070607	hsa-miR-302c	CLIP-seq
MIRT1070608	hsa-miR-302d	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070609	hsa-miR-3158-5p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT1070610	hsa-miR-372	CLIP-seq
MIRT1070611	hsa-miR-373	CLIP-seq
MIRT1070621	hsa-miR-4661-5p	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT1070616	hsa-miR-519d	CLIP-seq
MIRT1070617	hsa-miR-520g	CLIP-seq
MIRT1070618	hsa-miR-544	CLIP-seq
MIRT1070619	hsa-miR-552	CLIP-seq
MIRT1070620	hsa-miR-93	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT1070561	hsa-miR-1272	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT1070563	hsa-miR-1322	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT1070567	hsa-miR-3134	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT1070622	hsa-miR-323-5p	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT1070575	hsa-miR-3664-5p	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT1070623	hsa-miR-4438	CLIP-seq
MIRT1070581	hsa-miR-4534	CLIP-seq
MIRT1070582	hsa-miR-4639-3p	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT1070624	hsa-miR-4742-5p	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT1070625	hsa-miR-582-5p	CLIP-seq
MIRT1070626	hsa-miR-876-3p	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT2017341	hsa-miR-125a-3p	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2017344	hsa-miR-192	CLIP-seq
MIRT2017345	hsa-miR-215	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT2017348	hsa-miR-3187-3p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2017351	hsa-miR-3545-3p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2017353	hsa-miR-3934	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2017355	hsa-miR-4435	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2017357	hsa-miR-4635	CLIP-seq
MIRT2017358	hsa-miR-4680-5p	CLIP-seq
MIRT2017359	hsa-miR-4701-5p	CLIP-seq
MIRT2017360	hsa-miR-4716-5p	CLIP-seq
MIRT2017361	hsa-miR-4755-3p	CLIP-seq
MIRT2017362	hsa-miR-4781-3p	CLIP-seq
MIRT2017363	hsa-miR-548s	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT2017365	hsa-miR-588	CLIP-seq
MIRT2017366	hsa-miR-764	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT2249249	hsa-miR-1264	CLIP-seq
MIRT2249250	hsa-miR-1227	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT2249252	hsa-miR-1908	CLIP-seq
MIRT1070565	hsa-miR-1909	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT2249253	hsa-miR-3120-3p	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2249255	hsa-miR-3192	CLIP-seq
MIRT2249256	hsa-miR-3612	CLIP-seq
MIRT2249257	hsa-miR-3616-5p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT2249259	hsa-miR-3647-5p	CLIP-seq
MIRT2249260	hsa-miR-3689a-3p	CLIP-seq
MIRT2249261	hsa-miR-3689c	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2249263	hsa-miR-4252	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT2249265	hsa-miR-4537	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT2249266	hsa-miR-4670-3p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT2249267	hsa-miR-4728-5p	CLIP-seq
MIRT2249268	hsa-miR-4793-3p	CLIP-seq
MIRT2249269	hsa-miR-508-5p	CLIP-seq
MIRT2249270	hsa-miR-545	CLIP-seq
MIRT2249271	hsa-miR-573	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2249273	hsa-miR-650	CLIP-seq
MIRT2249274	hsa-miR-661	CLIP-seq
MIRT2249275	hsa-miR-663	CLIP-seq
MIRT2249276	hsa-miR-766	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT2451927	hsa-miR-128	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT2451928	hsa-miR-3147	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2451929	hsa-miR-3613-3p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT2451930	hsa-miR-3675-3p	CLIP-seq
MIRT2451931	hsa-miR-371-5p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT2451932	hsa-miR-4260	CLIP-seq
MIRT2451933	hsa-miR-4283	CLIP-seq
MIRT2451934	hsa-miR-4425	CLIP-seq
MIRT2451935	hsa-miR-4432	CLIP-seq
MIRT2451936	hsa-miR-4489	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2451937	hsa-miR-451b	CLIP-seq
MIRT2451938	hsa-miR-4684-5p	CLIP-seq
MIRT2451939	hsa-miR-4696	CLIP-seq
MIRT2451940	hsa-miR-548c-3p	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2552788	hsa-miR-1207-3p	CLIP-seq
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT2552789	hsa-miR-1244	CLIP-seq
MIRT2451927	hsa-miR-128	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2552790	hsa-miR-190	CLIP-seq
MIRT2552791	hsa-miR-190b	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2552792	hsa-miR-297	CLIP-seq
MIRT2249253	hsa-miR-3120-3p	CLIP-seq
MIRT2552793	hsa-miR-3132	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT2552794	hsa-miR-3149	CLIP-seq
MIRT2552795	hsa-miR-3158-3p	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2451929	hsa-miR-3613-3p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT2552796	hsa-miR-3659	CLIP-seq
MIRT2451930	hsa-miR-3675-3p	CLIP-seq
MIRT2552797	hsa-miR-3681	CLIP-seq
MIRT2552798	hsa-miR-3692	CLIP-seq
MIRT2451931	hsa-miR-371-5p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2552799	hsa-miR-378g	CLIP-seq
MIRT2552800	hsa-miR-383	CLIP-seq
MIRT2552801	hsa-miR-3942-3p	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2249263	hsa-miR-4252	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT2451935	hsa-miR-4432	CLIP-seq
MIRT2552802	hsa-miR-4446-3p	CLIP-seq
MIRT2552803	hsa-miR-4464	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2552804	hsa-miR-4506	CLIP-seq
MIRT2451937	hsa-miR-451b	CLIP-seq
MIRT2451938	hsa-miR-4684-5p	CLIP-seq
MIRT2552805	hsa-miR-4690-3p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT2451939	hsa-miR-4696	CLIP-seq
MIRT1070586	hsa-miR-4735-5p	CLIP-seq
MIRT2552806	hsa-miR-4748	CLIP-seq
MIRT1070587	hsa-miR-4775	CLIP-seq
MIRT2249268	hsa-miR-4793-3p	CLIP-seq
MIRT2249269	hsa-miR-508-5p	CLIP-seq
MIRT2249270	hsa-miR-545	CLIP-seq
MIRT2451940	hsa-miR-548c-3p	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT2552807	hsa-miR-567	CLIP-seq
MIRT1070589	hsa-miR-590-3p	CLIP-seq
MIRT2552808	hsa-miR-595	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2552809	hsa-miR-646	CLIP-seq
MIRT2249274	hsa-miR-661	CLIP-seq
MIRT2552810	hsa-miR-759	CLIP-seq
MIRT2552811	hsa-miR-760	CLIP-seq
MIRT2249276	hsa-miR-766	CLIP-seq
MIRT2552788	hsa-miR-1207-3p	CLIP-seq
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT2249250	hsa-miR-1227	CLIP-seq
MIRT2552789	hsa-miR-1244	CLIP-seq
MIRT2451927	hsa-miR-128	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2552790	hsa-miR-190	CLIP-seq
MIRT2552791	hsa-miR-190b	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2552792	hsa-miR-297	CLIP-seq
MIRT2249253	hsa-miR-3120-3p	CLIP-seq
MIRT2552793	hsa-miR-3132	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT2552795	hsa-miR-3158-3p	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2451929	hsa-miR-3613-3p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT2552796	hsa-miR-3659	CLIP-seq
MIRT2451930	hsa-miR-3675-3p	CLIP-seq
MIRT2552797	hsa-miR-3681	CLIP-seq
MIRT2451931	hsa-miR-371-5p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2552799	hsa-miR-378g	CLIP-seq
MIRT2552800	hsa-miR-383	CLIP-seq
MIRT2552801	hsa-miR-3942-3p	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2249263	hsa-miR-4252	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT2451935	hsa-miR-4432	CLIP-seq
MIRT2552802	hsa-miR-4446-3p	CLIP-seq
MIRT2682906	hsa-miR-4476	CLIP-seq
MIRT2682907	hsa-miR-4493	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2552804	hsa-miR-4506	CLIP-seq
MIRT2451937	hsa-miR-451b	CLIP-seq
MIRT2451938	hsa-miR-4684-5p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT2451939	hsa-miR-4696	CLIP-seq
MIRT2249268	hsa-miR-4793-3p	CLIP-seq
MIRT2249269	hsa-miR-508-5p	CLIP-seq
MIRT2249270	hsa-miR-545	CLIP-seq
MIRT2451940	hsa-miR-548c-3p	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT2552807	hsa-miR-567	CLIP-seq
MIRT2552808	hsa-miR-595	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2552809	hsa-miR-646	CLIP-seq
MIRT2249274	hsa-miR-661	CLIP-seq
MIRT2552810	hsa-miR-759	CLIP-seq
MIRT2552811	hsa-miR-760	CLIP-seq
MIRT2249276	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	TAS	21269878
GO:0002446	Process	Neutrophil mediated immunity	IMP	19663824
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS	21269878
GO:0004672	Function	Protein kinase activity	EXP	11960013
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	11960013
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005149	Function	Interleukin-1 receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	12496252, 12860405, 19264966, 20485341, 21903422, 23376919, 24316379, 25502805, 25910212, 26871637, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007254	Process	JNK cascade	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0034162	Process	Toll-like receptor 9 signaling pathway	TAS
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	22158417
GO:0045087	Process	Innate immune response	TAS	21269878
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IEA
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1990266	Process	Neutrophil migration	IMP	19663824

Other IDs

• MIM: 606883
• HGNC: 17967
• e!Ensembl: ENSG00000198001

Protein

• UniProt ID: Q9NWZ3
• Protein name: Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
• Protein function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the
• PDB: 2NRU, 2NRY, 2O8Y, 2OIB, 2OIC, 2OID, 3MOP, 4RMZ, 4U97, 4U9A, 4XS2, 4Y73, 4YO6, 4YP8, 4ZTL, 4ZTM, 4ZTN, 5K72, 5K75, 5K76, 5K7G, 5K7I, 5KX7, 5KX8, 5T1S, 5T1T, 5UIQ, 5UIR, 5UIS, 5UIT, 5UIU, 5W84, 5W85, 6EG9, 6EGA, 6EGD, 6EGE, 6EGF, 6F3D, 6F3E, 6F3G, 6F3I, 6LXY, 6MOM, 6N8G, 6O8U, 6O94, 6O95, 6O9D, 6RFI, 6RFJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07714	PK_Tyr_Ser-Thr	187 → 454	Protein tyrosine and serine/threonine kinase	Domain

• Sequence:

  MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
  QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
  QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
  DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
  QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
  FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
  RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
  ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

• Sequence length: 460

Pathways

KEGG:

MAPK signaling pathway
NF-kappa B signaling pathway
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Neurotrophin signaling pathway
Alcoholic liver disease
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Yersinia infection
Leishmaniasis
Chagas disease
Toxoplasmosis
Tuberculosis
Hepatitis B
Measles
Influenza A
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Lipid and atherosclerosis

Reactome:

PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Immunodeficiency	Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency	rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs121918314, rs587776713, rs137852678, rs587776714, rs128620188, rs2147483647, rs1569556522, rs137853331, rs137853332, rs179363866, rs483352928, rs121918659, rs111033580, rs111033581, rs74315290, rs193922740, rs193922741, rs104894199, rs483352927, rs104894286, rs1571865049, rs886041032, rs2069709, rs587776822, rs74315444, rs587776823, rs1315265916, rs104893893, rs104893894, rs121434560, rs387906572, rs587776853, rs104893973, rs587776854, rs587776855, rs587776857, rs104893974, rs121912715, rs1393707607, rs113994136, rs387906593, rs587776870, rs387906763, rs387906913, rs199469663, rs199469662, rs199469664, rs193922640, rs193922641, rs193922645, rs398122890, rs387907316, rs397514710, rs398122383, rs397515453, rs397514332, rs398123058, rs397518423, rs587777075, rs199676861, rs77563738, rs587777337, rs28730670, rs587777389, rs587777390, rs587777413, rs587777414, rs587777415, rs587777416, rs267608260, rs267608261, rs587778405, rs587777446, rs587777562, rs587777564, rs587777565, rs869320745, rs587777709, rs606231305, rs672601318, rs727503779, rs727503780, rs730880296, rs786200953, rs375323253, rs794729666, rs886041037, rs886041038, rs796051887, rs796051888, rs749956849, rs199641706, rs775739391, rs869312886, rs869312857, rs879253731, rs879253732, rs201025290, rs770927552, rs878853275, rs878853276, rs878853277, rs878853278, rs1567506566, rs886037920, rs886037921, rs750610248, rs200044623, rs886043118, rs886060531, rs1057519074, rs1057519075, rs1057518744, rs1057519079, rs1057518745, rs1057518746, rs1057518747, rs782178147, rs55729925, rs1064795762, rs1064794957, rs1085307649, rs745463649, rs773694113, rs1192554889, rs779575307, rs1554051075, rs1554051067, rs1554051033, rs1554067182, rs1555167566, rs1555169270, rs1555908409, rs1555719963, rs1554064929, rs768091235, rs1404084330, rs144104577, rs1553238837, rs1553243550, rs1554020278, rs1554066684, rs762678772, rs570768621, rs1443126481, rs1553721236, rs121434258, rs888230251, rs1759915032, rs1759514836, rs138156467, rs1560914625, rs755373718, rs1561423197, rs1560938296, rs200803157, rs766555082, rs201543770, rs114951157, rs775578531, rs201128237, rs778624945, rs1563340753, rs1561772403, rs1484948342, rs777878144, rs1562364898, rs1561254290, rs1569296295, rs1568815169, rs1568822574, rs1571880832, rs934523851, rs1922072844, rs1266114717, rs137869655, rs869320689, rs1571880941, rs1580875488, rs1581303476, rs1448018291, rs1390410878, rs774803573, rs1591278347, rs1602300615, rs1601340933, rs757598952, rs1181595292, rs1408683294, rs1595843113, rs1595848141, rs779560450, rs1595816926, rs1601861196, rs1601861199, rs756541321, rs1594389703, rs1594390415, rs1581401865, rs1236009877, rs753213766, rs778993919, rs1602878106, rs141698985, rs1264504989, rs1580974401, rs2093571190, rs530286781, rs2086875746, rs2089298923, rs1206185362, rs1581573705, rs1596718225, rs1004337827, rs1573613529, rs1574636674, rs1574657735, rs1574657762, rs1574672718, rs1581573640, rs1553657429, rs200666300, rs1578735747, rs1578771211, rs1578793312, rs1578795536, rs1578809101, rs1578811073, rs1578811245, rs1171694504, rs1578971328, rs140800288, rs374333820, rs1584926133, rs1585040113, rs1584409386, rs1379376784, rs1586940273, rs1587143342, rs748910652, rs1592117677, rs758555433, rs1596712783, rs34019455, rs147766868, rs751386365, rs1600631294, rs1489114116, rs1057520578, rs1603007888, rs1603008329, rs1574450161, rs1578735709, rs1403833564, rs1580262965, rs570910902, rs1589866171, rs1578999313, rs1582635229, rs1582637044, rs1580851910, rs1750760771, rs745453685, rs1249197356, rs201840561, rs1940921909, rs1941410085, rs1941465194, rs1321690789, rs1302362911, rs1730552437, rs2052705192, rs1941856970
Neutropenia	Neutropenia	rs879253882
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16537705

Unknown
Disease name	Disease term	dbSNP ID	References
Anorexia	Anoxia-Ischemia, Brain, Anoxia-Ischemia, Cerebral		21925238
Anoxic-ischemic encephalopathy	Anoxic-Ischemic Encephalopathy		21925238
Cerebral hypoxia-ischemia	Cerebral Hypoxia-Ischemia		21925238
Hypoxic-ischemic encephalopathy	Hypoxic-Ischemic Encephalopathy		21925238
Immunologic deficiency syndromes	Immunologic Deficiency Syndromes
Irak4 deficiency	IRAK4 Deficiency		24316379, 12637671, 17878374, 12925671, 19663824, 21057262
Ischemic encephalopathy	Hypoxia-Ischemia, Brain		21925238
Lupus erythematosus	Lupus Erythematosus, Systemic		28003376
Nonbacterial verrucal endocardiosis	Libman-Sacks Disease		28003376
Prostatic neoplasms	Prostatic Neoplasms		16537705