CRYL1 (crystallin lambda 1)

Gene

• Entrez ID: 51084
• Gene name: Crystallin lambda 1
• Gene symbol: CRYL1
• Synonyms: GDH, HEL30, gul3DH, lambda-CRY
• Chromosome: 13
• Chromosome location: 13q12.11
• Summary: The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme req

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029226	hsa-miR-26b-5p	Microarray	19088304
MIRT911182	hsa-miR-1587	CLIP-seq
MIRT911183	hsa-miR-1915	CLIP-seq
MIRT911184	hsa-miR-3605-3p	CLIP-seq
MIRT911185	hsa-miR-3609	CLIP-seq
MIRT911186	hsa-miR-4417	CLIP-seq
MIRT911187	hsa-miR-4492	CLIP-seq
MIRT911188	hsa-miR-4498	CLIP-seq
MIRT911189	hsa-miR-4632	CLIP-seq
MIRT911190	hsa-miR-4656	CLIP-seq
MIRT911191	hsa-miR-4661-3p	CLIP-seq
MIRT911192	hsa-miR-4675	CLIP-seq
MIRT911193	hsa-miR-4685-5p	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911195	hsa-miR-4741	CLIP-seq
MIRT911196	hsa-miR-4755-3p	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT911198	hsa-miR-520g	CLIP-seq
MIRT911199	hsa-miR-520h	CLIP-seq
MIRT911200	hsa-miR-548ah	CLIP-seq
MIRT911201	hsa-miR-640	CLIP-seq
MIRT911202	hsa-miR-651	CLIP-seq
MIRT911203	hsa-miR-762	CLIP-seq
MIRT1970202	hsa-miR-3190	CLIP-seq
MIRT1970203	hsa-miR-671-5p	CLIP-seq
MIRT2206130	hsa-miR-3155	CLIP-seq
MIRT2206131	hsa-miR-3155b	CLIP-seq
MIRT1970202	hsa-miR-3190	CLIP-seq
MIRT2206132	hsa-miR-4286	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT2206133	hsa-miR-484	CLIP-seq
MIRT2206134	hsa-miR-510	CLIP-seq
MIRT1970203	hsa-miR-671-5p	CLIP-seq
MIRT2509285	hsa-miR-1234	CLIP-seq
MIRT2509286	hsa-miR-1296	CLIP-seq
MIRT911182	hsa-miR-1587	CLIP-seq
MIRT2509287	hsa-miR-3130-3p	CLIP-seq
MIRT2206130	hsa-miR-3155	CLIP-seq
MIRT2206131	hsa-miR-3155b	CLIP-seq
MIRT2509288	hsa-miR-3158-3p	CLIP-seq
MIRT1970202	hsa-miR-3190	CLIP-seq
MIRT911184	hsa-miR-3605-3p	CLIP-seq
MIRT2509289	hsa-miR-3920	CLIP-seq
MIRT2509290	hsa-miR-4255	CLIP-seq
MIRT2206132	hsa-miR-4286	CLIP-seq
MIRT2509291	hsa-miR-4327	CLIP-seq
MIRT911186	hsa-miR-4417	CLIP-seq
MIRT2509292	hsa-miR-4446-3p	CLIP-seq
MIRT911187	hsa-miR-4492	CLIP-seq
MIRT911188	hsa-miR-4498	CLIP-seq
MIRT2509293	hsa-miR-4512	CLIP-seq
MIRT911190	hsa-miR-4656	CLIP-seq
MIRT911191	hsa-miR-4661-3p	CLIP-seq
MIRT911192	hsa-miR-4675	CLIP-seq
MIRT2509294	hsa-miR-4712-3p	CLIP-seq
MIRT2509295	hsa-miR-4721	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911195	hsa-miR-4741	CLIP-seq
MIRT2509296	hsa-miR-4771	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT2206133	hsa-miR-484	CLIP-seq
MIRT2206134	hsa-miR-510	CLIP-seq
MIRT911202	hsa-miR-651	CLIP-seq
MIRT1970203	hsa-miR-671-5p	CLIP-seq
MIRT911203	hsa-miR-762	CLIP-seq
MIRT2509297	hsa-miR-767-5p	CLIP-seq
MIRT2509285	hsa-miR-1234	CLIP-seq
MIRT2509286	hsa-miR-1296	CLIP-seq
MIRT911182	hsa-miR-1587	CLIP-seq
MIRT2509287	hsa-miR-3130-3p	CLIP-seq
MIRT2206130	hsa-miR-3155	CLIP-seq
MIRT2206131	hsa-miR-3155b	CLIP-seq
MIRT2509288	hsa-miR-3158-3p	CLIP-seq
MIRT911184	hsa-miR-3605-3p	CLIP-seq
MIRT2509289	hsa-miR-3920	CLIP-seq
MIRT2509290	hsa-miR-4255	CLIP-seq
MIRT2206132	hsa-miR-4286	CLIP-seq
MIRT2509291	hsa-miR-4327	CLIP-seq
MIRT911186	hsa-miR-4417	CLIP-seq
MIRT2509292	hsa-miR-4446-3p	CLIP-seq
MIRT911187	hsa-miR-4492	CLIP-seq
MIRT911188	hsa-miR-4498	CLIP-seq
MIRT2509293	hsa-miR-4512	CLIP-seq
MIRT911190	hsa-miR-4656	CLIP-seq
MIRT911191	hsa-miR-4661-3p	CLIP-seq
MIRT911192	hsa-miR-4675	CLIP-seq
MIRT2509295	hsa-miR-4721	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911195	hsa-miR-4741	CLIP-seq
MIRT2509296	hsa-miR-4771	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT2206133	hsa-miR-484	CLIP-seq
MIRT2206134	hsa-miR-510	CLIP-seq
MIRT911202	hsa-miR-651	CLIP-seq
MIRT911203	hsa-miR-762	CLIP-seq
MIRT2509297	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003857	Function	3-hydroxyacyl-CoA dehydrogenase activity	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA	21873635
GO:0019640	Process	Glucuronate catabolic process to xylulose 5-phosphate	TAS
GO:0042803	Function	Protein homodimerization activity	IPI	15809331
GO:0050104	Function	L-gulonate 3-dehydrogenase activity	IBA	21873635
GO:0050104	Function	L-gulonate 3-dehydrogenase activity	IDA	15809331
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070403	Function	NAD+ binding	IDA	15809331

Other IDs

• MIM: 609877
• HGNC: 18246
• e!Ensembl: ENSG00000165475

Protein

• UniProt ID: Q9Y2S2
• Protein name: Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH)
• Protein function: Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
• PDB: 3F3S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02737	3HCDH_N	8 → 190	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	Domain
  PF00725	3HCDH	192 → 283	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	Domain

• Sequence:

  MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAG
  SLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILS
  SSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIG
  QCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLET
  MHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQ
  WRDECLMRLAKLKSQVQPQ

• Sequence length: 319

Pathways

KEGG:

Pentose and glucuronate interconversions
Metabolic pathways

Reactome:

Formation of xylulose-5-phosphate

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Necrotizing enterocolitis	Necrotizing Enterocolitis		18806098
Prostatic neoplasms	Prostatic Neoplasms		17013881