PCM1 (pericentriolar material 1)

Gene

• Entrez ID: 5108
• Gene name: Pericentriolar material 1
• Gene symbol: PCM1
• Synonyms: PTC4, RET/PCM-1
• Chromosome: 8
• Chromosome location: 8p22
• Summary: The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049852	hsa-miR-33a-5p	CLASH	23622248
MIRT1217846	hsa-miR-1193	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT1217848	hsa-miR-1267	CLIP-seq
MIRT1217849	hsa-miR-1305	CLIP-seq
MIRT1217850	hsa-miR-141	CLIP-seq
MIRT1217851	hsa-miR-15a	CLIP-seq
MIRT1217852	hsa-miR-15b	CLIP-seq
MIRT1217853	hsa-miR-16	CLIP-seq
MIRT1217854	hsa-miR-186	CLIP-seq
MIRT1217855	hsa-miR-1913	CLIP-seq
MIRT1217856	hsa-miR-192	CLIP-seq
MIRT1217857	hsa-miR-195	CLIP-seq
MIRT1217858	hsa-miR-200a	CLIP-seq
MIRT1217859	hsa-miR-215	CLIP-seq
MIRT1217860	hsa-miR-216b	CLIP-seq
MIRT1217861	hsa-miR-3065-5p	CLIP-seq
MIRT1217862	hsa-miR-3133	CLIP-seq
MIRT1217863	hsa-miR-3148	CLIP-seq
MIRT1217864	hsa-miR-3150a-3p	CLIP-seq
MIRT1217865	hsa-miR-3154	CLIP-seq
MIRT1217866	hsa-miR-3175	CLIP-seq
MIRT1217867	hsa-miR-3179	CLIP-seq
MIRT1217868	hsa-miR-324-3p	CLIP-seq
MIRT1217869	hsa-miR-34b	CLIP-seq
MIRT1217870	hsa-miR-3613-3p	CLIP-seq
MIRT1217871	hsa-miR-3646	CLIP-seq
MIRT1217872	hsa-miR-3662	CLIP-seq
MIRT1217873	hsa-miR-3667-5p	CLIP-seq
MIRT1217874	hsa-miR-3672	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT1217876	hsa-miR-424	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT1217878	hsa-miR-4668-5p	CLIP-seq
MIRT1217879	hsa-miR-4705	CLIP-seq
MIRT1217880	hsa-miR-4707-3p	CLIP-seq
MIRT1217881	hsa-miR-4716-3p	CLIP-seq
MIRT1217882	hsa-miR-4720-5p	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT1217884	hsa-miR-4797-5p	CLIP-seq
MIRT1217885	hsa-miR-4799-3p	CLIP-seq
MIRT1217886	hsa-miR-497	CLIP-seq
MIRT1217887	hsa-miR-539	CLIP-seq
MIRT1217888	hsa-miR-607	CLIP-seq
MIRT1217889	hsa-miR-625	CLIP-seq
MIRT1217890	hsa-miR-720	CLIP-seq
MIRT1217891	hsa-miR-939	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT2062974	hsa-miR-122	CLIP-seq
MIRT2062975	hsa-miR-1234	CLIP-seq
MIRT2062976	hsa-miR-1307	CLIP-seq
MIRT2062977	hsa-miR-150	CLIP-seq
MIRT1217851	hsa-miR-15a	CLIP-seq
MIRT1217852	hsa-miR-15b	CLIP-seq
MIRT1217853	hsa-miR-16	CLIP-seq
MIRT2062978	hsa-miR-18a	CLIP-seq
MIRT2062979	hsa-miR-18b	CLIP-seq
MIRT2062980	hsa-miR-1911	CLIP-seq
MIRT1217857	hsa-miR-195	CLIP-seq
MIRT2062981	hsa-miR-3135b	CLIP-seq
MIRT2062982	hsa-miR-3622b-5p	CLIP-seq
MIRT2062983	hsa-miR-3652	CLIP-seq
MIRT2062984	hsa-miR-3671	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT1217876	hsa-miR-424	CLIP-seq
MIRT2062985	hsa-miR-4284	CLIP-seq
MIRT2062986	hsa-miR-4307	CLIP-seq
MIRT2062987	hsa-miR-4328	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT2062988	hsa-miR-4430	CLIP-seq
MIRT2062989	hsa-miR-4502	CLIP-seq
MIRT2062990	hsa-miR-4520a-3p	CLIP-seq
MIRT2062991	hsa-miR-4638-5p	CLIP-seq
MIRT2062992	hsa-miR-4695-3p	CLIP-seq
MIRT2062993	hsa-miR-4700-3p	CLIP-seq
MIRT2062994	hsa-miR-4731-5p	CLIP-seq
MIRT2062995	hsa-miR-4735-3p	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT2062996	hsa-miR-4761-5p	CLIP-seq
MIRT2062997	hsa-miR-4762-3p	CLIP-seq
MIRT2062998	hsa-miR-4762-5p	CLIP-seq
MIRT2062999	hsa-miR-4772-3p	CLIP-seq
MIRT1217886	hsa-miR-497	CLIP-seq
MIRT2063000	hsa-miR-5095	CLIP-seq
MIRT2291401	hsa-miR-101	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT2062974	hsa-miR-122	CLIP-seq
MIRT2062975	hsa-miR-1234	CLIP-seq
MIRT1217848	hsa-miR-1267	CLIP-seq
MIRT2062976	hsa-miR-1307	CLIP-seq
MIRT2291402	hsa-miR-144	CLIP-seq
MIRT2062977	hsa-miR-150	CLIP-seq
MIRT2062978	hsa-miR-18a	CLIP-seq
MIRT2062979	hsa-miR-18b	CLIP-seq
MIRT1217855	hsa-miR-1913	CLIP-seq
MIRT2291403	hsa-miR-28-3p	CLIP-seq
MIRT2062981	hsa-miR-3135b	CLIP-seq
MIRT2291404	hsa-miR-3155	CLIP-seq
MIRT2291405	hsa-miR-3155b	CLIP-seq
MIRT1217868	hsa-miR-324-3p	CLIP-seq
MIRT2062982	hsa-miR-3622b-5p	CLIP-seq
MIRT2062983	hsa-miR-3652	CLIP-seq
MIRT2291406	hsa-miR-3942-5p	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT2062985	hsa-miR-4284	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT2062988	hsa-miR-4430	CLIP-seq
MIRT2291407	hsa-miR-4433	CLIP-seq
MIRT2291408	hsa-miR-4532	CLIP-seq
MIRT2062991	hsa-miR-4638-5p	CLIP-seq
MIRT2062992	hsa-miR-4695-3p	CLIP-seq
MIRT2062993	hsa-miR-4700-3p	CLIP-seq
MIRT2291409	hsa-miR-4703-5p	CLIP-seq
MIRT1217880	hsa-miR-4707-3p	CLIP-seq
MIRT2291410	hsa-miR-4714-3p	CLIP-seq
MIRT2062994	hsa-miR-4731-5p	CLIP-seq
MIRT2062995	hsa-miR-4735-3p	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT2062996	hsa-miR-4761-5p	CLIP-seq
MIRT2062999	hsa-miR-4772-3p	CLIP-seq
MIRT2291411	hsa-miR-484	CLIP-seq
MIRT2063000	hsa-miR-5095	CLIP-seq
MIRT1217890	hsa-miR-720	CLIP-seq
MIRT2062975	hsa-miR-1234	CLIP-seq
MIRT2062977	hsa-miR-150	CLIP-seq
MIRT2062978	hsa-miR-18a	CLIP-seq
MIRT2062979	hsa-miR-18b	CLIP-seq
MIRT2062994	hsa-miR-4731-5p	CLIP-seq
MIRT2062995	hsa-miR-4735-3p	CLIP-seq
MIRT2062996	hsa-miR-4761-5p	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT2062974	hsa-miR-122	CLIP-seq
MIRT1217848	hsa-miR-1267	CLIP-seq
MIRT2062981	hsa-miR-3135b	CLIP-seq
MIRT2062982	hsa-miR-3622b-5p	CLIP-seq
MIRT2062983	hsa-miR-3652	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT2062988	hsa-miR-4430	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT1217884	hsa-miR-4797-5p	CLIP-seq
MIRT1217890	hsa-miR-720	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT2062974	hsa-miR-122	CLIP-seq
MIRT1217848	hsa-miR-1267	CLIP-seq
MIRT2062981	hsa-miR-3135b	CLIP-seq
MIRT2062983	hsa-miR-3652	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT2062988	hsa-miR-4430	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT1217884	hsa-miR-4797-5p	CLIP-seq
MIRT1217890	hsa-miR-720	CLIP-seq
MIRT1217846	hsa-miR-1193	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT2062974	hsa-miR-122	CLIP-seq
MIRT2588889	hsa-miR-1256	CLIP-seq
MIRT1217848	hsa-miR-1267	CLIP-seq
MIRT2588890	hsa-miR-127-5p	CLIP-seq
MIRT2062976	hsa-miR-1307	CLIP-seq
MIRT2062977	hsa-miR-150	CLIP-seq
MIRT2588891	hsa-miR-193a-3p	CLIP-seq
MIRT2588892	hsa-miR-193b	CLIP-seq
MIRT2588893	hsa-miR-1976	CLIP-seq
MIRT2062981	hsa-miR-3135b	CLIP-seq
MIRT2588894	hsa-miR-3136-5p	CLIP-seq
MIRT2291404	hsa-miR-3155	CLIP-seq
MIRT2291405	hsa-miR-3155b	CLIP-seq
MIRT2588895	hsa-miR-3163	CLIP-seq
MIRT2588896	hsa-miR-3176	CLIP-seq
MIRT2062982	hsa-miR-3622b-5p	CLIP-seq
MIRT2062983	hsa-miR-3652	CLIP-seq
MIRT2588897	hsa-miR-3921	CLIP-seq
MIRT2588898	hsa-miR-3922-3p	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT2588899	hsa-miR-410	CLIP-seq
MIRT2588900	hsa-miR-4259	CLIP-seq
MIRT2588901	hsa-miR-4279	CLIP-seq
MIRT2062985	hsa-miR-4284	CLIP-seq
MIRT2588902	hsa-miR-4289	CLIP-seq
MIRT2588903	hsa-miR-4303	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT2062988	hsa-miR-4430	CLIP-seq
MIRT2588904	hsa-miR-4439	CLIP-seq
MIRT2588905	hsa-miR-4463	CLIP-seq
MIRT2588906	hsa-miR-4468	CLIP-seq
MIRT2291408	hsa-miR-4532	CLIP-seq
MIRT2062991	hsa-miR-4638-5p	CLIP-seq
MIRT2588907	hsa-miR-4653-5p	CLIP-seq
MIRT2062992	hsa-miR-4695-3p	CLIP-seq
MIRT2588908	hsa-miR-4713-5p	CLIP-seq
MIRT2588909	hsa-miR-4715-3p	CLIP-seq
MIRT2588910	hsa-miR-4715-5p	CLIP-seq
MIRT2588911	hsa-miR-4718	CLIP-seq
MIRT2588912	hsa-miR-4722-3p	CLIP-seq
MIRT2588913	hsa-miR-4735-5p	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT2062999	hsa-miR-4772-3p	CLIP-seq
MIRT2588914	hsa-miR-4775	CLIP-seq
MIRT2588915	hsa-miR-4786-3p	CLIP-seq
MIRT1217884	hsa-miR-4797-5p	CLIP-seq
MIRT2291411	hsa-miR-484	CLIP-seq
MIRT2588916	hsa-miR-532-3p	CLIP-seq
MIRT2588917	hsa-miR-561	CLIP-seq
MIRT2588918	hsa-miR-590-3p	CLIP-seq
MIRT2588919	hsa-miR-618	CLIP-seq
MIRT2588920	hsa-miR-653	CLIP-seq
MIRT2588921	hsa-miR-7	CLIP-seq
MIRT1217890	hsa-miR-720	CLIP-seq
MIRT2588922	hsa-miR-942	CLIP-seq
MIRT2588923	hsa-miR-943	CLIP-seq
MIRT1217846	hsa-miR-1193	CLIP-seq
MIRT1217847	hsa-miR-1202	CLIP-seq
MIRT2062974	hsa-miR-122	CLIP-seq
MIRT2588889	hsa-miR-1256	CLIP-seq
MIRT1217848	hsa-miR-1267	CLIP-seq
MIRT2062976	hsa-miR-1307	CLIP-seq
MIRT2062977	hsa-miR-150	CLIP-seq
MIRT2588891	hsa-miR-193a-3p	CLIP-seq
MIRT2588892	hsa-miR-193b	CLIP-seq
MIRT2588893	hsa-miR-1976	CLIP-seq
MIRT2062981	hsa-miR-3135b	CLIP-seq
MIRT2291404	hsa-miR-3155	CLIP-seq
MIRT2291405	hsa-miR-3155b	CLIP-seq
MIRT2588895	hsa-miR-3163	CLIP-seq
MIRT2588896	hsa-miR-3176	CLIP-seq
MIRT2062982	hsa-miR-3622b-5p	CLIP-seq
MIRT2062983	hsa-miR-3652	CLIP-seq
MIRT2588897	hsa-miR-3921	CLIP-seq
MIRT2588898	hsa-miR-3922-3p	CLIP-seq
MIRT1217875	hsa-miR-3972	CLIP-seq
MIRT2588899	hsa-miR-410	CLIP-seq
MIRT2687256	hsa-miR-411	CLIP-seq
MIRT2588900	hsa-miR-4259	CLIP-seq
MIRT2588901	hsa-miR-4279	CLIP-seq
MIRT2062985	hsa-miR-4284	CLIP-seq
MIRT2588903	hsa-miR-4303	CLIP-seq
MIRT1217877	hsa-miR-4423-5p	CLIP-seq
MIRT2062988	hsa-miR-4430	CLIP-seq
MIRT2588905	hsa-miR-4463	CLIP-seq
MIRT2588906	hsa-miR-4468	CLIP-seq
MIRT2291408	hsa-miR-4532	CLIP-seq
MIRT2062991	hsa-miR-4638-5p	CLIP-seq
MIRT2588907	hsa-miR-4653-5p	CLIP-seq
MIRT2062992	hsa-miR-4695-3p	CLIP-seq
MIRT2588908	hsa-miR-4713-5p	CLIP-seq
MIRT2588909	hsa-miR-4715-3p	CLIP-seq
MIRT2588910	hsa-miR-4715-5p	CLIP-seq
MIRT2588912	hsa-miR-4722-3p	CLIP-seq
MIRT2588913	hsa-miR-4735-5p	CLIP-seq
MIRT1217883	hsa-miR-4755-3p	CLIP-seq
MIRT2062999	hsa-miR-4772-3p	CLIP-seq
MIRT2588914	hsa-miR-4775	CLIP-seq
MIRT1217884	hsa-miR-4797-5p	CLIP-seq
MIRT2291411	hsa-miR-484	CLIP-seq
MIRT2588916	hsa-miR-532-3p	CLIP-seq
MIRT2588917	hsa-miR-561	CLIP-seq
MIRT2588918	hsa-miR-590-3p	CLIP-seq
MIRT2588919	hsa-miR-618	CLIP-seq
MIRT2588921	hsa-miR-7	CLIP-seq
MIRT1217890	hsa-miR-720	CLIP-seq
MIRT2588922	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000242	Component	Pericentriolar material	ISS
GO:0001764	Process	Neuron migration	IEA
GO:0005515	Function	Protein binding	IPI	9361024, 14520415, 15107855, 16189514, 17574030, 18000879, 18762586, 18772192, 19081074, 19447967, 20719959, 22500027, 24089205, 24397932, 24550735, 24816561, 25074808, 25416956, 26297806, 26496610, 26638075, 28235840, 28712572, 29892012, 31515488
GO:0005737	Component	Cytoplasm	ISS
GO:0005813	Component	Centrosome	IDA	20719959, 21399614, 22797915, 24421332, 24550735
GO:0005813	Component	Centrosome	IDA	24648492
GO:0005813	Component	Centrosome	ISS
GO:0005814	Component	Centriole	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007098	Process	Centrosome cycle	IBA	21873635
GO:0007098	Process	Centrosome cycle	IMP	17574030
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0022027	Process	Interkinetic nuclear migration	ISS
GO:0031122	Process	Cytoplasmic microtubule organization	IMP	22797915, 24816561
GO:0031965	Component	Nuclear membrane	IDA
GO:0032991	Component	Protein-containing complex	IDA	24421332
GO:0034451	Component	Centriolar satellite	IBA	21873635
GO:0034451	Component	Centriolar satellite	IDA	15616553, 17574030, 20719959, 24550735
GO:0034453	Process	Microtubule anchoring	ISS
GO:0034454	Process	Microtubule anchoring at centrosome	IBA	21873635
GO:0035176	Process	Social behavior	IEA
GO:0035735	Process	Intraciliary transport involved in cilium assembly	IBA	21873635
GO:0035735	Process	Intraciliary transport involved in cilium assembly	IMP	24550735
GO:0035869	Component	Ciliary transition zone	IDA	24415959
GO:0036064	Component	Ciliary basal body	IBA	21873635
GO:0042802	Function	Identical protein binding	ISS
GO:0045177	Component	Apical part of cell	IEA
GO:0050768	Process	Negative regulation of neurogenesis	ISS
GO:0060271	Process	Cilium assembly	IMP	15616553, 17574030
GO:0071539	Process	Protein localization to centrosome	IBA	21873635
GO:0071539	Process	Protein localization to centrosome	IMP	24816561
GO:0071539	Process	Protein localization to centrosome	ISS
GO:0090316	Process	Positive regulation of intracellular protein transport	IMP	22797915, 24550735
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0097711	Process	Ciliary basal body-plasma membrane docking	TAS
GO:0097730	Component	Non-motile cilium	IDA	17574030
GO:1905515	Process	Non-motile cilium assembly	IMP	23789104

Other IDs

• MIM: 600299
• HGNC: 8727
• e!Ensembl: ENSG00000078674

Protein

• UniProt ID: Q15154
• Protein name: Pericentriolar material 1 protein (PCM-1) (hPCM-1)
• Protein function: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651).
• PDB: 6HYL, 6HYM, 7Q46
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15717	PCM1_C	1372 → 1998	Pericentriolar material 1 C terminus	Family

• Sequence:

  MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRV
  TNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSD
  SQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
  NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT
  HLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
  AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
  VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTL
  RDQHLNNSSASPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN
  EGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
  NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
  LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKIN
  RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
  QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASV
  GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRR
  KQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
  EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFS
  ADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTL
  MQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
  ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMN
  FSPLFPSNFGDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
  EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
  FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESAS
  MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEA
  LRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
  GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
  NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVN
  NLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQL
  LTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVL
  FNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDK
  DKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTNYGSGE
  DENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATS
  KNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKE
  VKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEAD
  LRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQSI

• Sequence length: 2024

Pathways

Reactome:

Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	26503814
Papillary thyroid carcinoma	Papillary thyroid carcinoma	rs751409106	10980597
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19048012

Unknown
Disease name	Disease term	dbSNP ID	References
Thyroid carcinoma	Differentiated thyroid carcinoma