ZBTB7B (zinc finger and BTB domain containing 7B)
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Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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51043 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Zinc finger and BTB domain containing 7B |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ZBTB7B |
SynonymsGene synonyms aliases
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CKROX, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, vGAF |
ChromosomeChromosome number
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1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q21.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It als |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
ISS |
|
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000987 |
Function |
Cis-regulatory region sequence-specific DNA binding |
ISS |
|
GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IEA |
|
GO:0001865 |
Process |
NK T cell differentiation |
ISS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
21516116, 25416956 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0006366 |
Process |
Transcription by RNA polymerase II |
TAS |
7937772 |
GO:0007398 |
Process |
Ectoderm development |
TAS |
7937772 |
GO:0007595 |
Process |
Lactation |
ISS |
|
GO:0010628 |
Process |
Positive regulation of gene expression |
IBA |
21873635 |
GO:0010628 |
Process |
Positive regulation of gene expression |
ISS |
|
GO:0031065 |
Process |
Positive regulation of histone deacetylation |
ISS |
|
GO:0032620 |
Process |
Interleukin-17 production |
ISS |
|
GO:0032868 |
Process |
Response to insulin |
ISS |
|
GO:0042803 |
Function |
Protein homodimerization activity |
ISS |
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GO:0042826 |
Function |
Histone deacetylase binding |
IEA |
|
GO:0043372 |
Process |
Positive regulation of CD4-positive, alpha-beta T cell differentiation |
ISS |
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GO:0043377 |
Process |
Negative regulation of CD8-positive, alpha-beta T cell differentiation |
ISS |
|
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IEA |
|
GO:0046628 |
Process |
Positive regulation of insulin receptor signaling pathway |
ISS |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0051141 |
Process |
Negative regulation of NK T cell proliferation |
ISS |
|
GO:0090336 |
Process |
Positive regulation of brown fat cell differentiation |
ISS |
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GO:0120162 |
Process |
Positive regulation of cold-induced thermogenesis |
ISS |
28784777 |
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
GO:1990845 |
Process |
Adaptive thermogenesis |
ISS |
|
GO:2000320 |
Process |
Negative regulation of T-helper 17 cell differentiation |
IEA |
|
GO:2000640 |
Process |
Positive regulation of SREBP signaling pathway |
ISS |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O15156 |
Protein name |
Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger p |
Protein function |
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00651 |
BTB |
24 → 145 |
BTB/POZ domain |
Domain |
PF00096 |
zf-C2H2 |
374 → 396 |
Zinc finger, C2H2 type |
Domain |
PF00096 |
zf-C2H2 |
430 → 451 |
Zinc finger, C2H2 type |
Domain |
|
Sequence |
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Sequence length |
539 |
Interactions |
View interactions |
Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Basal cell neoplasm |
Basal Cell Neoplasm, Basal Cell Cancer |
rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813 |
31174203 |
Carcinoma |
Basal cell carcinoma |
rs121912654, rs555607708, rs786202962, rs1564055259 |
31174203 |
Obesity |
Obesity |
rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 |
29273807 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Eczema |
Eczema |
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30595370 |
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