NTM (neurotrimin)

Gene

• Entrez ID: 50863
• Gene name: Neurotrimin
• Gene symbol: NTM
• Synonyms: CEPU-1, HNT, IGLON2, NTRI
• Chromosome: 11
• Chromosome location: 11q25
• Summary: This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006824	hsa-miR-182-5p	Luciferase reporter assay, Western blot	22917588
MIRT006824	hsa-miR-182-5p	Luciferase reporter assay, Western blot	22917588
MIRT645476	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT645475	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT645474	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT645473	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT645476	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT645475	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT645474	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT645473	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT1196059	hsa-miR-1207-3p	CLIP-seq
MIRT1196060	hsa-miR-1825	CLIP-seq
MIRT1196061	hsa-miR-199a-5p	CLIP-seq
MIRT1196062	hsa-miR-199b-5p	CLIP-seq
MIRT1196063	hsa-miR-3159	CLIP-seq
MIRT1196064	hsa-miR-3545-5p	CLIP-seq
MIRT1196065	hsa-miR-369-3p	CLIP-seq
MIRT1196066	hsa-miR-374a	CLIP-seq
MIRT1196067	hsa-miR-374b	CLIP-seq
MIRT1196068	hsa-miR-3925-3p	CLIP-seq
MIRT1196069	hsa-miR-513b	CLIP-seq
MIRT1196070	hsa-miR-568	CLIP-seq
MIRT1196071	hsa-miR-766	CLIP-seq
MIRT1196072	hsa-miR-1225-3p	CLIP-seq
MIRT1196073	hsa-miR-1233	CLIP-seq
MIRT1196074	hsa-miR-129-3p	CLIP-seq
MIRT1196075	hsa-miR-3929	CLIP-seq
MIRT1196076	hsa-miR-4265	CLIP-seq
MIRT1196077	hsa-miR-4296	CLIP-seq
MIRT1196078	hsa-miR-4322	CLIP-seq
MIRT1196079	hsa-miR-4417	CLIP-seq
MIRT1196080	hsa-miR-4419b	CLIP-seq
MIRT1196081	hsa-miR-4478	CLIP-seq
MIRT1196082	hsa-miR-4663	CLIP-seq
MIRT1196083	hsa-miR-485-5p	CLIP-seq
MIRT1551898	hsa-miR-4434	CLIP-seq
MIRT1551899	hsa-miR-4436b-3p	CLIP-seq
MIRT1551900	hsa-miR-4516	CLIP-seq
MIRT1551901	hsa-miR-4531	CLIP-seq
MIRT1551902	hsa-miR-614	CLIP-seq
MIRT1556743	hsa-miR-4532	CLIP-seq
MIRT1196060	hsa-miR-1825	CLIP-seq
MIRT1196061	hsa-miR-199a-5p	CLIP-seq
MIRT1196062	hsa-miR-199b-5p	CLIP-seq
MIRT2056885	hsa-miR-323-5p	CLIP-seq
MIRT1196064	hsa-miR-3545-5p	CLIP-seq
MIRT1196068	hsa-miR-3925-3p	CLIP-seq
MIRT2056886	hsa-miR-4467	CLIP-seq
MIRT1556743	hsa-miR-4532	CLIP-seq
MIRT1196071	hsa-miR-766	CLIP-seq
MIRT2056887	hsa-miR-876-3p	CLIP-seq
MIRT2583424	hsa-miR-1301	CLIP-seq
MIRT1196060	hsa-miR-1825	CLIP-seq
MIRT1196061	hsa-miR-199a-5p	CLIP-seq
MIRT1196062	hsa-miR-199b-5p	CLIP-seq
MIRT2583425	hsa-miR-2116	CLIP-seq
MIRT2583426	hsa-miR-3122	CLIP-seq
MIRT2583427	hsa-miR-3153	CLIP-seq
MIRT1196063	hsa-miR-3159	CLIP-seq
MIRT2583428	hsa-miR-3163	CLIP-seq
MIRT1196064	hsa-miR-3545-5p	CLIP-seq
MIRT1196065	hsa-miR-369-3p	CLIP-seq
MIRT1196066	hsa-miR-374a	CLIP-seq
MIRT1196067	hsa-miR-374b	CLIP-seq
MIRT2583429	hsa-miR-377	CLIP-seq
MIRT2583430	hsa-miR-3910	CLIP-seq
MIRT2583431	hsa-miR-3913-5p	CLIP-seq
MIRT2583432	hsa-miR-3919	CLIP-seq
MIRT1196068	hsa-miR-3925-3p	CLIP-seq
MIRT2583433	hsa-miR-3941	CLIP-seq
MIRT2583434	hsa-miR-4275	CLIP-seq
MIRT2583435	hsa-miR-4327	CLIP-seq
MIRT2583436	hsa-miR-4455	CLIP-seq
MIRT2583437	hsa-miR-466	CLIP-seq
MIRT2583438	hsa-miR-4660	CLIP-seq
MIRT2583439	hsa-miR-4668-5p	CLIP-seq
MIRT2583440	hsa-miR-4672	CLIP-seq
MIRT2583441	hsa-miR-4677-5p	CLIP-seq
MIRT2583442	hsa-miR-4711-5p	CLIP-seq
MIRT2583443	hsa-miR-4719	CLIP-seq
MIRT2583444	hsa-miR-4731-3p	CLIP-seq
MIRT2583445	hsa-miR-4756-3p	CLIP-seq
MIRT2583446	hsa-miR-4801	CLIP-seq
MIRT2583447	hsa-miR-5047	CLIP-seq
MIRT2583448	hsa-miR-548an	CLIP-seq
MIRT1196070	hsa-miR-568	CLIP-seq
MIRT2583449	hsa-miR-583	CLIP-seq
MIRT2583450	hsa-miR-618	CLIP-seq
MIRT1196071	hsa-miR-766	CLIP-seq
MIRT2686656	hsa-miR-3183	CLIP-seq
MIRT2686657	hsa-miR-339-5p	CLIP-seq
MIRT2686658	hsa-miR-4421	CLIP-seq
MIRT2686659	hsa-miR-4723-3p	CLIP-seq
MIRT2686660	hsa-miR-593	CLIP-seq
MIRT2686661	hsa-miR-642a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21982860, 25416956, 31515488
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0008038	Process	Neuron recognition	TAS	7891157
GO:0031225	Component	Anchored component of membrane	IEA

Other IDs

• MIM: 607938
• HGNC: 17941
• e!Ensembl: ENSG00000182667

Protein

• UniProt ID: Q9P121
• Protein name: Neurotrimin (hNT) (IgLON family member 2)
• Protein function: Neural cell adhesion molecule.
• PDB: 6DLF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	36 → 132	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	135 → 205		Domain
  PF13927	Ig_3	222 → 299		Domain

• Sequence:

  MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTID
  NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD
  NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFV
  SEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGT
  LQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK
  LGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF

• Sequence length: 344

Pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	27021288
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	27182965
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21926974, 31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	21036197