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IRX4 (iroquois homeobox 4)

Gene

50805

Iroquois homeobox 4

IRX4

IRXA3

5p15.33

Show/Hide all(111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024687	hsa-miR-215-5p	Microarray	19074876
MIRT026778	hsa-miR-192-5p	Microarray	19074876
MIRT1072379	hsa-miR-1279	CLIP-seq
MIRT1072380	hsa-miR-1289	CLIP-seq
MIRT1072381	hsa-miR-130a	CLIP-seq
MIRT1072382	hsa-miR-130b	CLIP-seq
MIRT1072383	hsa-miR-148a	CLIP-seq
MIRT1072384	hsa-miR-148b	CLIP-seq
MIRT1072385	hsa-miR-152	CLIP-seq
MIRT1072386	hsa-miR-1538	CLIP-seq
MIRT1072387	hsa-miR-19a	CLIP-seq
MIRT1072388	hsa-miR-19b	CLIP-seq
MIRT1072389	hsa-miR-301a	CLIP-seq
MIRT1072390	hsa-miR-301b	CLIP-seq
MIRT1072391	hsa-miR-302a	CLIP-seq
MIRT1072392	hsa-miR-302b	CLIP-seq
MIRT1072393	hsa-miR-302c	CLIP-seq
MIRT1072394	hsa-miR-302d	CLIP-seq
MIRT1072395	hsa-miR-302e	CLIP-seq
MIRT1072396	hsa-miR-30a	CLIP-seq
MIRT1072397	hsa-miR-30b	CLIP-seq
MIRT1072398	hsa-miR-30c	CLIP-seq
MIRT1072399	hsa-miR-30d	CLIP-seq
MIRT1072400	hsa-miR-30e	CLIP-seq
MIRT1072401	hsa-miR-3122	CLIP-seq
MIRT1072402	hsa-miR-3198	CLIP-seq
MIRT1072403	hsa-miR-335	CLIP-seq
MIRT1072404	hsa-miR-3666	CLIP-seq
MIRT1072405	hsa-miR-372	CLIP-seq
MIRT1072406	hsa-miR-373	CLIP-seq
MIRT1072407	hsa-miR-3913-5p	CLIP-seq
MIRT1072408	hsa-miR-4294	CLIP-seq
MIRT1072409	hsa-miR-4295	CLIP-seq
MIRT1072410	hsa-miR-4309	CLIP-seq
MIRT1072411	hsa-miR-454	CLIP-seq
MIRT1072412	hsa-miR-4696	CLIP-seq
MIRT1072413	hsa-miR-4745-3p	CLIP-seq
MIRT1072414	hsa-miR-4802-5p	CLIP-seq
MIRT1072415	hsa-miR-491-3p	CLIP-seq
MIRT1072416	hsa-miR-512-3p	CLIP-seq
MIRT1072417	hsa-miR-520a-3p	CLIP-seq
MIRT1072418	hsa-miR-520b	CLIP-seq
MIRT1072419	hsa-miR-520c-3p	CLIP-seq
MIRT1072420	hsa-miR-520d-3p	CLIP-seq
MIRT1072421	hsa-miR-520e	CLIP-seq
MIRT1072422	hsa-miR-574-5p	CLIP-seq
MIRT1072423	hsa-miR-648	CLIP-seq
MIRT1072424	hsa-miR-656	CLIP-seq
MIRT2017860	hsa-miR-922	CLIP-seq
MIRT1072379	hsa-miR-1279	CLIP-seq
MIRT1072380	hsa-miR-1289	CLIP-seq
MIRT1072381	hsa-miR-130a	CLIP-seq
MIRT1072382	hsa-miR-130b	CLIP-seq
MIRT1072383	hsa-miR-148a	CLIP-seq
MIRT1072384	hsa-miR-148b	CLIP-seq
MIRT1072385	hsa-miR-152	CLIP-seq
MIRT2249662	hsa-miR-1915	CLIP-seq
MIRT1072387	hsa-miR-19a	CLIP-seq
MIRT1072388	hsa-miR-19b	CLIP-seq
MIRT1072389	hsa-miR-301a	CLIP-seq
MIRT1072390	hsa-miR-301b	CLIP-seq
MIRT1072391	hsa-miR-302a	CLIP-seq
MIRT1072392	hsa-miR-302b	CLIP-seq
MIRT1072393	hsa-miR-302c	CLIP-seq
MIRT1072394	hsa-miR-302d	CLIP-seq
MIRT1072395	hsa-miR-302e	CLIP-seq
MIRT2249663	hsa-miR-3126-3p	CLIP-seq
MIRT2249664	hsa-miR-3127-5p	CLIP-seq
MIRT2249665	hsa-miR-3195	CLIP-seq
MIRT1072402	hsa-miR-3198	CLIP-seq
MIRT1072403	hsa-miR-335	CLIP-seq
MIRT2249666	hsa-miR-3650	CLIP-seq
MIRT1072404	hsa-miR-3666	CLIP-seq
MIRT2249667	hsa-miR-3691-3p	CLIP-seq
MIRT1072405	hsa-miR-372	CLIP-seq
MIRT1072406	hsa-miR-373	CLIP-seq
MIRT2249668	hsa-miR-3977	CLIP-seq
MIRT1072408	hsa-miR-4294	CLIP-seq
MIRT1072409	hsa-miR-4295	CLIP-seq
MIRT1072410	hsa-miR-4309	CLIP-seq
MIRT2249669	hsa-miR-4422	CLIP-seq
MIRT2249670	hsa-miR-4433	CLIP-seq
MIRT2249671	hsa-miR-4459	CLIP-seq
MIRT1072411	hsa-miR-454	CLIP-seq
MIRT2249672	hsa-miR-4690-5p	CLIP-seq
MIRT2249673	hsa-miR-4695-5p	CLIP-seq
MIRT1072412	hsa-miR-4696	CLIP-seq
MIRT2249674	hsa-miR-4707-5p	CLIP-seq
MIRT2249675	hsa-miR-4710	CLIP-seq
MIRT2249676	hsa-miR-4716-5p	CLIP-seq
MIRT2249677	hsa-miR-4726-3p	CLIP-seq
MIRT2249678	hsa-miR-4742-5p	CLIP-seq
MIRT2249679	hsa-miR-4792	CLIP-seq
MIRT1072414	hsa-miR-4802-5p	CLIP-seq
MIRT1072415	hsa-miR-491-3p	CLIP-seq
MIRT1072416	hsa-miR-512-3p	CLIP-seq
MIRT1072417	hsa-miR-520a-3p	CLIP-seq
MIRT1072418	hsa-miR-520b	CLIP-seq
MIRT1072419	hsa-miR-520c-3p	CLIP-seq
MIRT1072420	hsa-miR-520d-3p	CLIP-seq
MIRT1072421	hsa-miR-520e	CLIP-seq
MIRT1072422	hsa-miR-574-5p	CLIP-seq
MIRT1072423	hsa-miR-648	CLIP-seq
MIRT1072424	hsa-miR-656	CLIP-seq
MIRT2249680	hsa-miR-665	CLIP-seq
MIRT2249681	hsa-miR-885-3p	CLIP-seq
MIRT2249682	hsa-miR-944	CLIP-seq
MIRT2249663	hsa-miR-3126-3p	CLIP-seq
MIRT2389474	hsa-miR-3176	CLIP-seq
MIRT2389475	hsa-miR-3922-3p	CLIP-seq
MIRT2249676	hsa-miR-4716-5p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007507	Process	Heart development	IEA
GO:0030182	Process	Neuron differentiation	IBA	21873635
GO:0048468	Process	Cell development	IBA	21873635
GO:0048561	Process	Establishment of animal organ orientation	IEA

MIM	HGNC	e!Ensembl
606199	6129	ENSG00000113430

Protein

UniProt ID

P78413

Protein name

Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4)

Protein function

Likely to be an important mediator of ventricular differentiation during cardiac development.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05920	Homeobox_KN	160 → 199	Homeobox KN domain	Family

Sequence

MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATA
RHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAA
AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEA
SGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASA
GLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPH
SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANV
LTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA

Sequence length

519

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenoid Cystic Carcinoma	rs121913530, rs886039394, rs121913474	16762588
Ventricular septal defect	Ventricular Septal Defects	rs104894073, rs387906775	21544582

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Salivary gland neoplasm	Salivary Gland Neoplasms		16762588
Malignant neoplasm of salivary gland	Malignant neoplasm of salivary gland		16762588

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