CNTN3 (contactin 3)

Gene

• Entrez ID: 5067
• Gene name: Contactin 3
• Gene symbol: CNTN3
• Synonyms: BIG-1, PANG, PCS
• Chromosome: 3
• Chromosome location: 3p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT901666	hsa-miR-129-5p	CLIP-seq
MIRT901667	hsa-miR-21	CLIP-seq
MIRT901668	hsa-miR-331-5p	CLIP-seq
MIRT901669	hsa-miR-3664-3p	CLIP-seq
MIRT901670	hsa-miR-383	CLIP-seq
MIRT901671	hsa-miR-4311	CLIP-seq
MIRT901672	hsa-miR-4464	CLIP-seq
MIRT901673	hsa-miR-4678	CLIP-seq
MIRT901674	hsa-miR-4727-5p	CLIP-seq
MIRT901675	hsa-miR-4748	CLIP-seq
MIRT901676	hsa-miR-4764-3p	CLIP-seq
MIRT901677	hsa-miR-4766-5p	CLIP-seq
MIRT901678	hsa-miR-4769-3p	CLIP-seq
MIRT901679	hsa-miR-4772-5p	CLIP-seq
MIRT901680	hsa-miR-4775	CLIP-seq
MIRT901681	hsa-miR-510	CLIP-seq
MIRT901682	hsa-miR-548aa	CLIP-seq
MIRT901683	hsa-miR-548ae	CLIP-seq
MIRT901684	hsa-miR-548aj	CLIP-seq
MIRT901685	hsa-miR-548am	CLIP-seq
MIRT901686	hsa-miR-548x	CLIP-seq
MIRT901687	hsa-miR-590-5p	CLIP-seq
MIRT901688	hsa-miR-873	CLIP-seq
MIRT1967472	hsa-miR-485-3p	CLIP-seq
MIRT2203181	hsa-miR-103a	CLIP-seq
MIRT2203182	hsa-miR-107	CLIP-seq
MIRT2203183	hsa-miR-15a	CLIP-seq
MIRT2203184	hsa-miR-15b	CLIP-seq
MIRT2203185	hsa-miR-16	CLIP-seq
MIRT2203186	hsa-miR-195	CLIP-seq
MIRT2203187	hsa-miR-424	CLIP-seq
MIRT2203188	hsa-miR-4524	CLIP-seq
MIRT2203189	hsa-miR-497	CLIP-seq
MIRT2203190	hsa-miR-503	CLIP-seq
MIRT2203191	hsa-miR-646	CLIP-seq
MIRT2386322	hsa-miR-3942-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0031225	Component	Anchored component of membrane	IEA
GO:0043005	Component	Neuron projection	IBA	21873635

Other IDs

• MIM: 601325
• HGNC: 2173
• e!Ensembl: ENSG00000113805

Protein

• UniProt ID: Q9P232
• Protein name: Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein)
• Protein function: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).
• PDB: 1WJ3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13927	Ig_3	26 → 104		Domain
  PF13927	Ig_3	125 → 200		Domain
  PF13927	Ig_3	226 → 301		Domain
  PF07679	I-set	318 → 403	Immunoglobulin I-set domain	Domain
  PF07679	I-set	408 → 496	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	500 → 580		Domain
  PF00041	fn3	599 → 687	Fibronectin type III domain	Domain
  PF00041	fn3	702 → 790	Fibronectin type III domain	Domain
  PF00041	fn3	804 → 891	Fibronectin type III domain	Domain
  PF00041	fn3	904 → 986	Fibronectin type III domain	Domain

• Sequence:

  MMFPWKQLILLSFIGCLGGELLLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHY
  RWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAY
  LENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGH
  LYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAA
  KGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAE
  NSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL
  EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQ
  VQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCM
  AENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGA
  LADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGP
  PENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTA
  TVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVIT
  WDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGV
  YNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEV
  RYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKK
  TPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSA
  ELVLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDARGSTSAISNVHPMSSYMPIVL
  FLIVYVLW

• Sequence length: 1028

Pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	18621663
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	17597826

Unknown
Disease name	Disease term	dbSNP ID	References
Vascular diseases	Peripheral Arterial Diseases		27082954