PAK2 (p21 (RAC1) activated kinase 2)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5062 |
Gene nameGene Name - the full gene name approved by the HGNC.
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P21 (RAC1) activated kinase 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PAK2 |
SynonymsGene synonyms aliases
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KNO2, PAK65, PAKgamma |
ChromosomeChromosome number
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3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q29 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 an |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0002223 |
Process |
Stimulatory C-type lectin receptor signaling pathway |
TAS |
|
GO:0004672 |
Function |
Protein kinase activity |
TAS |
10748018 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
EXP |
11278486 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IBA |
21873635 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IDA |
11121037, 11805089 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
TAS |
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GO:0005515 |
Function |
Protein binding |
IPI |
10607567, 16374509, 16527308, 16787945, 16837009, 18716323, 19240112, 19264842, 19435845, 20696164, 20936779, 21516116, 21555521, 22705156, 25416956, 28514442, 32296183 |
GO:0005524 |
Function |
ATP binding |
IEA |
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GO:0005634 |
Component |
Nucleus |
IEA |
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GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
25468996 |
GO:0005829 |
Component |
Cytosol |
IDA |
8625410 |
GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0005886 |
Component |
Plasma membrane |
TAS |
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GO:0005911 |
Component |
Cell-cell junction |
IMP |
25753039 |
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
11805089 |
GO:0006469 |
Process |
Negative regulation of protein kinase activity |
TAS |
10748018 |
GO:0006915 |
Process |
Apoptotic process |
IEA |
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GO:0014069 |
Component |
Postsynaptic density |
IEA |
|
GO:0016310 |
Process |
Phosphorylation |
IDA |
21555521 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IDA |
11121037 |
GO:0019901 |
Function |
Protein kinase binding |
IPI |
11121037 |
GO:0030296 |
Function |
Protein tyrosine kinase activator activity |
IDA |
11121037 |
GO:0031098 |
Process |
Stress-activated protein kinase signaling cascade |
IBA |
21873635 |
GO:0031267 |
Function |
Small GTPase binding |
IPI |
8625410 |
GO:0031295 |
Process |
T cell costimulation |
TAS |
|
GO:0032147 |
Process |
Activation of protein kinase activity |
IBA |
21873635 |
GO:0034333 |
Process |
Adherens junction assembly |
IMP |
25753039 |
GO:0035722 |
Process |
Interleukin-12-mediated signaling pathway |
TAS |
|
GO:0038095 |
Process |
Fc-epsilon receptor signaling pathway |
TAS |
|
GO:0040008 |
Process |
Regulation of growth |
IEA |
|
GO:0042802 |
Function |
Identical protein binding |
IPI |
16837009 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IMP |
21555521 |
GO:0045296 |
Function |
Cadherin binding |
HDA |
25468996 |
GO:0046777 |
Process |
Protein autophosphorylation |
IDA |
11805089 |
GO:0048010 |
Process |
Vascular endothelial growth factor receptor signaling pathway |
TAS |
|
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IEA |
|
GO:0050690 |
Process |
Regulation of defense response to virus by virus |
TAS |
|
GO:0050731 |
Process |
Positive regulation of peptidyl-tyrosine phosphorylation |
IDA |
11121037 |
GO:0050770 |
Process |
Regulation of axonogenesis |
IBA |
21873635 |
GO:0050852 |
Process |
T cell receptor signaling pathway |
TAS |
|
GO:0051493 |
Process |
Regulation of cytoskeleton organization |
IMP |
25753039 |
GO:0051497 |
Process |
Negative regulation of stress fiber assembly |
IMP |
25753039 |
GO:0060996 |
Process |
Dendritic spine development |
IEA |
|
GO:0061098 |
Process |
Positive regulation of protein tyrosine kinase activity |
IEA |
|
GO:0070830 |
Process |
Bicellular tight junction assembly |
IMP |
25753039 |
GO:0071407 |
Process |
Cellular response to organic cyclic compound |
IEA |
|
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:0106310 |
Function |
Protein serine kinase activity |
IEA |
|
GO:0106311 |
Function |
Protein threonine kinase activity |
IEA |
|
GO:0150105 |
Process |
Protein localization to cell-cell junction |
IMP |
25753039 |
GO:2001238 |
Process |
Positive regulation of extrinsic apoptotic signaling pathway |
IMP |
19240112 |
GO:2001271 |
Process |
Negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
IDA |
21555521 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q13177 |
Protein name |
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] |
Protein function |
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:1927359 |
PDB |
3PCS
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00786 |
PBD |
73 → 131 |
P21-Rho-binding domain |
Domain |
PF00069 |
Pkinase |
249 → 500 |
Protein kinase domain |
Domain |
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Sequence |
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Sequence length |
524 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Atrial fibrillation |
Atrial Fibrillation |
rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675 |
29892015 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
20691406 |
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