FURIN (furin, paired basic amino acid cleaving enzyme)

Gene

• Entrez ID: 5045
• Gene name: Furin, paired basic amino acid cleaving enzyme
• Gene symbol: FURIN
• Synonyms: FUR, PACE, PCSK3, SPC1
• Chromosome: 15
• Chromosome location: 15q26.1
• Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005919	hsa-miR-24-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20945401
MIRT027060	hsa-miR-103a-3p	Sequencing	20371350
MIRT031785	hsa-miR-16-5p	Sequencing	20371350
MIRT042240	hsa-miR-484	CLASH	23622248
MIRT039979	hsa-miR-615-3p	CLASH	23622248
MIRT005919	hsa-miR-24-3p	qRT-PCR, Western blot	22260784
MIRT476700	hsa-miR-107	PAR-CLIP	23592263
MIRT027060	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT031785	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT476699	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT476698	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT476697	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT476696	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT476695	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT476694	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT476693	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT476692	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT476691	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT476690	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT476689	hsa-miR-4286	PAR-CLIP	23592263
MIRT476688	hsa-miR-6089	PAR-CLIP	23592263
MIRT476686	hsa-miR-4505	PAR-CLIP	23592263
MIRT476687	hsa-miR-5787	PAR-CLIP	23592263
MIRT476685	hsa-miR-3153	PAR-CLIP	23592263
MIRT476684	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT476683	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT476682	hsa-miR-6508-3p	PAR-CLIP	23592263
MIRT476681	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT476680	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT476679	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT476678	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT027060	hsa-miR-103a-3p	PAR-CLIP	26701625
MIRT476700	hsa-miR-107	PAR-CLIP	26701625
MIRT476679	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT476693	hsa-miR-140-3p	PAR-CLIP	26701625
MIRT476698	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT476699	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT031785	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT476697	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT476685	hsa-miR-3153	PAR-CLIP	26701625
MIRT476696	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT476689	hsa-miR-4286	PAR-CLIP	26701625
MIRT476686	hsa-miR-4505	PAR-CLIP	26701625
MIRT476695	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT476687	hsa-miR-5787	PAR-CLIP	26701625
MIRT476688	hsa-miR-6089	PAR-CLIP	26701625
MIRT476682	hsa-miR-6508-3p	PAR-CLIP	26701625
MIRT476684	hsa-miR-6733-5p	PAR-CLIP	26701625
MIRT476683	hsa-miR-6739-5p	PAR-CLIP	26701625
MIRT476681	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT476692	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT476680	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT476678	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT476690	hsa-miR-6783-5p	PAR-CLIP	26701625
MIRT476694	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT476691	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT476700	hsa-miR-107	PAR-CLIP	23592263
MIRT027060	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT031785	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT476699	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT476698	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT476697	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT476696	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT476695	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT476694	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT476693	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT476692	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT476691	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT476690	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT476689	hsa-miR-4286	PAR-CLIP	23592263
MIRT476688	hsa-miR-6089	PAR-CLIP	23592263
MIRT476686	hsa-miR-4505	PAR-CLIP	23592263
MIRT476687	hsa-miR-5787	PAR-CLIP	23592263
MIRT476685	hsa-miR-3153	PAR-CLIP	23592263
MIRT476684	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT476683	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT476682	hsa-miR-6508-3p	PAR-CLIP	23592263
MIRT476681	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT476680	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT476679	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT476678	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT1006206	hsa-miR-103a	CLIP-seq
MIRT1006207	hsa-miR-106a	CLIP-seq
MIRT1006208	hsa-miR-106b	CLIP-seq
MIRT1006209	hsa-miR-1224-3p	CLIP-seq
MIRT1006210	hsa-miR-1227	CLIP-seq
MIRT1006211	hsa-miR-1234	CLIP-seq
MIRT1006212	hsa-miR-124	CLIP-seq
MIRT1006213	hsa-miR-1275	CLIP-seq
MIRT1006214	hsa-miR-128	CLIP-seq
MIRT1006215	hsa-miR-148a	CLIP-seq
MIRT1006216	hsa-miR-148b	CLIP-seq
MIRT1006217	hsa-miR-152	CLIP-seq
MIRT1006218	hsa-miR-153	CLIP-seq
MIRT1006219	hsa-miR-15a	CLIP-seq
MIRT1006220	hsa-miR-15b	CLIP-seq
MIRT1006221	hsa-miR-16	CLIP-seq
MIRT1006222	hsa-miR-17	CLIP-seq
MIRT1006223	hsa-miR-195	CLIP-seq
MIRT1006224	hsa-miR-19a	CLIP-seq
MIRT1006225	hsa-miR-19b	CLIP-seq
MIRT1006226	hsa-miR-20a	CLIP-seq
MIRT1006227	hsa-miR-20b	CLIP-seq
MIRT1006228	hsa-miR-219-5p	CLIP-seq
MIRT1006229	hsa-miR-2355-3p	CLIP-seq
MIRT1006230	hsa-miR-24	CLIP-seq
MIRT1006231	hsa-miR-2861	CLIP-seq
MIRT1006232	hsa-miR-3128	CLIP-seq
MIRT1006233	hsa-miR-3130-3p	CLIP-seq
MIRT1006234	hsa-miR-3132	CLIP-seq
MIRT1006235	hsa-miR-3143	CLIP-seq
MIRT1006236	hsa-miR-3147	CLIP-seq
MIRT1006237	hsa-miR-3157-5p	CLIP-seq
MIRT1006238	hsa-miR-3179	CLIP-seq
MIRT1006239	hsa-miR-3199	CLIP-seq
MIRT1006240	hsa-miR-3202	CLIP-seq
MIRT1006241	hsa-miR-342-5p	CLIP-seq
MIRT1006242	hsa-miR-34b	CLIP-seq
MIRT1006243	hsa-miR-3609	CLIP-seq
MIRT1006244	hsa-miR-3614-5p	CLIP-seq
MIRT1006245	hsa-miR-3622a-5p	CLIP-seq
MIRT1006246	hsa-miR-3647-3p	CLIP-seq
MIRT1006247	hsa-miR-3908	CLIP-seq
MIRT1006248	hsa-miR-3936	CLIP-seq
MIRT1006249	hsa-miR-424	CLIP-seq
MIRT1006250	hsa-miR-4283	CLIP-seq
MIRT1006251	hsa-miR-4310	CLIP-seq
MIRT1006252	hsa-miR-4425	CLIP-seq
MIRT1006253	hsa-miR-4437	CLIP-seq
MIRT1006254	hsa-miR-4445	CLIP-seq
MIRT1006255	hsa-miR-4464	CLIP-seq
MIRT1006256	hsa-miR-448	CLIP-seq
MIRT1006257	hsa-miR-4506	CLIP-seq
MIRT1006258	hsa-miR-4509	CLIP-seq
MIRT1006259	hsa-miR-4533	CLIP-seq
MIRT1006260	hsa-miR-4650-3p	CLIP-seq
MIRT1006261	hsa-miR-4652-5p	CLIP-seq
MIRT1006262	hsa-miR-4663	CLIP-seq
MIRT1006263	hsa-miR-4664-5p	CLIP-seq
MIRT1006264	hsa-miR-4665-3p	CLIP-seq
MIRT1006265	hsa-miR-4665-5p	CLIP-seq
MIRT1006266	hsa-miR-4685-5p	CLIP-seq
MIRT1006267	hsa-miR-4691-3p	CLIP-seq
MIRT1006268	hsa-miR-4715-3p	CLIP-seq
MIRT1006269	hsa-miR-4717-3p	CLIP-seq
MIRT1006270	hsa-miR-4719	CLIP-seq
MIRT1006271	hsa-miR-4720-5p	CLIP-seq
MIRT1006272	hsa-miR-4731-5p	CLIP-seq
MIRT1006273	hsa-miR-4733-3p	CLIP-seq
MIRT1006274	hsa-miR-4740-5p	CLIP-seq
MIRT1006275	hsa-miR-4744	CLIP-seq
MIRT1006276	hsa-miR-4748	CLIP-seq
MIRT1006277	hsa-miR-4782-3p	CLIP-seq
MIRT1006278	hsa-miR-4793-3p	CLIP-seq
MIRT1006279	hsa-miR-4796-3p	CLIP-seq
MIRT1006280	hsa-miR-4799-3p	CLIP-seq
MIRT1006281	hsa-miR-4802-3p	CLIP-seq
MIRT1006282	hsa-miR-497	CLIP-seq
MIRT1006283	hsa-miR-506	CLIP-seq
MIRT1006284	hsa-miR-508-3p	CLIP-seq
MIRT1006285	hsa-miR-519d	CLIP-seq
MIRT1006286	hsa-miR-520g	CLIP-seq
MIRT1006287	hsa-miR-520h	CLIP-seq
MIRT1006288	hsa-miR-543	CLIP-seq
MIRT1006289	hsa-miR-548aa	CLIP-seq
MIRT1006290	hsa-miR-548ah	CLIP-seq
MIRT1006291	hsa-miR-548an	CLIP-seq
MIRT1006292	hsa-miR-634	CLIP-seq
MIRT1006293	hsa-miR-647	CLIP-seq
MIRT1006294	hsa-miR-676	CLIP-seq
MIRT1006295	hsa-miR-890	CLIP-seq
MIRT1006296	hsa-miR-93	CLIP-seq
MIRT1006207	hsa-miR-106a	CLIP-seq
MIRT1006208	hsa-miR-106b	CLIP-seq
MIRT1998174	hsa-miR-1207-5p	CLIP-seq
MIRT1006211	hsa-miR-1234	CLIP-seq
MIRT1998175	hsa-miR-125a-5p	CLIP-seq
MIRT1998176	hsa-miR-125b	CLIP-seq
MIRT1998177	hsa-miR-1270	CLIP-seq
MIRT1006214	hsa-miR-128	CLIP-seq
MIRT1998178	hsa-miR-1293	CLIP-seq
MIRT1006215	hsa-miR-148a	CLIP-seq
MIRT1006216	hsa-miR-148b	CLIP-seq
MIRT1006217	hsa-miR-152	CLIP-seq
MIRT1006222	hsa-miR-17	CLIP-seq
MIRT1998179	hsa-miR-185	CLIP-seq
MIRT1998180	hsa-miR-1909	CLIP-seq
MIRT1006226	hsa-miR-20a	CLIP-seq
MIRT1006227	hsa-miR-20b	CLIP-seq
MIRT1006230	hsa-miR-24	CLIP-seq
MIRT1998181	hsa-miR-3160-5p	CLIP-seq
MIRT1998182	hsa-miR-3173-3p	CLIP-seq
MIRT1998183	hsa-miR-323-5p	CLIP-seq
MIRT1006242	hsa-miR-34b	CLIP-seq
MIRT1006243	hsa-miR-3609	CLIP-seq
MIRT1998184	hsa-miR-3616-3p	CLIP-seq
MIRT1006246	hsa-miR-3647-3p	CLIP-seq
MIRT1998185	hsa-miR-371-5p	CLIP-seq
MIRT1998186	hsa-miR-371b-3p	CLIP-seq
MIRT1998187	hsa-miR-3940-3p	CLIP-seq
MIRT1998188	hsa-miR-4306	CLIP-seq
MIRT1998189	hsa-miR-4319	CLIP-seq
MIRT1998190	hsa-miR-432	CLIP-seq
MIRT1998191	hsa-miR-4324	CLIP-seq
MIRT1998192	hsa-miR-4436b-3p	CLIP-seq
MIRT1006253	hsa-miR-4437	CLIP-seq
MIRT1998193	hsa-miR-4483	CLIP-seq
MIRT1998194	hsa-miR-4492	CLIP-seq
MIRT1998195	hsa-miR-4498	CLIP-seq
MIRT1998196	hsa-miR-4514	CLIP-seq
MIRT1998197	hsa-miR-4525	CLIP-seq
MIRT1998198	hsa-miR-4531	CLIP-seq
MIRT1998199	hsa-miR-4644	CLIP-seq
MIRT1998200	hsa-miR-4645-5p	CLIP-seq
MIRT1998201	hsa-miR-4673	CLIP-seq
MIRT1006266	hsa-miR-4685-5p	CLIP-seq
MIRT1998202	hsa-miR-4690-3p	CLIP-seq
MIRT1998203	hsa-miR-4692	CLIP-seq
MIRT1998204	hsa-miR-4696	CLIP-seq
MIRT1998205	hsa-miR-4701-5p	CLIP-seq
MIRT1998206	hsa-miR-4716-3p	CLIP-seq
MIRT1006270	hsa-miR-4719	CLIP-seq
MIRT1006273	hsa-miR-4733-3p	CLIP-seq
MIRT1998207	hsa-miR-4733-5p	CLIP-seq
MIRT1998208	hsa-miR-4749-3p	CLIP-seq
MIRT1998209	hsa-miR-4763-3p	CLIP-seq
MIRT1006279	hsa-miR-4796-3p	CLIP-seq
MIRT1998210	hsa-miR-515-5p	CLIP-seq
MIRT1006285	hsa-miR-519d	CLIP-seq
MIRT1998211	hsa-miR-520f	CLIP-seq
MIRT1006286	hsa-miR-520g	CLIP-seq
MIRT1006287	hsa-miR-520h	CLIP-seq
MIRT1006289	hsa-miR-548aa	CLIP-seq
MIRT1006290	hsa-miR-548ah	CLIP-seq
MIRT1998212	hsa-miR-548t	CLIP-seq
MIRT1998213	hsa-miR-588	CLIP-seq
MIRT1998214	hsa-miR-604	CLIP-seq
MIRT1998215	hsa-miR-620	CLIP-seq
MIRT1006293	hsa-miR-647	CLIP-seq
MIRT1998216	hsa-miR-661	CLIP-seq
MIRT1998217	hsa-miR-762	CLIP-seq
MIRT1998218	hsa-miR-873	CLIP-seq
MIRT1006296	hsa-miR-93	CLIP-seq
MIRT1006230	hsa-miR-24	CLIP-seq
MIRT1006237	hsa-miR-3157-5p	CLIP-seq
MIRT1006250	hsa-miR-4283	CLIP-seq
MIRT1006253	hsa-miR-4437	CLIP-seq
MIRT1006266	hsa-miR-4685-5p	CLIP-seq
MIRT1006267	hsa-miR-4691-3p	CLIP-seq
MIRT1998207	hsa-miR-4733-5p	CLIP-seq
MIRT1998218	hsa-miR-873	CLIP-seq
MIRT2388245	hsa-miR-3652	CLIP-seq
MIRT2388246	hsa-miR-4430	CLIP-seq
MIRT2388247	hsa-miR-4436a	CLIP-seq
MIRT1006206	hsa-miR-103a	CLIP-seq
MIRT2437326	hsa-miR-1228	CLIP-seq
MIRT1998175	hsa-miR-125a-5p	CLIP-seq
MIRT1998176	hsa-miR-125b	CLIP-seq
MIRT1006219	hsa-miR-15a	CLIP-seq
MIRT1006220	hsa-miR-15b	CLIP-seq
MIRT1006221	hsa-miR-16	CLIP-seq
MIRT2437327	hsa-miR-1915	CLIP-seq
MIRT1006223	hsa-miR-195	CLIP-seq
MIRT2437328	hsa-miR-3165	CLIP-seq
MIRT1998183	hsa-miR-323-5p	CLIP-seq
MIRT1006249	hsa-miR-424	CLIP-seq
MIRT1006250	hsa-miR-4283	CLIP-seq
MIRT1998189	hsa-miR-4319	CLIP-seq
MIRT1998191	hsa-miR-4324	CLIP-seq
MIRT2437329	hsa-miR-4677-3p	CLIP-seq
MIRT2437330	hsa-miR-4679	CLIP-seq
MIRT1998208	hsa-miR-4749-3p	CLIP-seq
MIRT1006282	hsa-miR-497	CLIP-seq
MIRT2437331	hsa-miR-876-3p	CLIP-seq
MIRT1998177	hsa-miR-1270	CLIP-seq
MIRT1998179	hsa-miR-185	CLIP-seq
MIRT2535843	hsa-miR-192	CLIP-seq
MIRT2535844	hsa-miR-215	CLIP-seq
MIRT1006244	hsa-miR-3614-5p	CLIP-seq
MIRT1998188	hsa-miR-4306	CLIP-seq
MIRT1998190	hsa-miR-432	CLIP-seq
MIRT1998198	hsa-miR-4531	CLIP-seq
MIRT1998199	hsa-miR-4644	CLIP-seq
MIRT2535845	hsa-miR-4676-5p	CLIP-seq
MIRT2535846	hsa-miR-575	CLIP-seq
MIRT1998215	hsa-miR-620	CLIP-seq
MIRT1006295	hsa-miR-890	CLIP-seq
MIRT2437326	hsa-miR-1228	CLIP-seq
MIRT2681228	hsa-miR-1266	CLIP-seq
MIRT2681229	hsa-miR-3127-5p	CLIP-seq
MIRT2681230	hsa-miR-3918	CLIP-seq
MIRT1998192	hsa-miR-4436b-3p	CLIP-seq
MIRT2681231	hsa-miR-4518	CLIP-seq
MIRT1006266	hsa-miR-4685-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPB	Activation	8132667
GATA1	Unknown	12411321

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IMP	9130696, 11799113
GO:0000139	Component	Golgi membrane	TAS
GO:0001825	Process	Blastocyst formation	IEA
GO:0002020	Function	Protease binding	IPI	14744861
GO:0004175	Function	Endopeptidase activity	IDA	9242664, 17010968
GO:0004175	Function	Endopeptidase activity	IMP	20489134
GO:0004175	Function	Endopeptidase activity	TAS
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	IDA	7737999, 8615794, 10567353, 21763278
GO:0004252	Function	Serine-type endopeptidase activity	IMP	9130696, 11799113
GO:0004252	Function	Serine-type endopeptidase activity	TAS
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IDA	10567353
GO:0005515	Function	Protein binding	IPI	20608975, 21152186, 23829672, 25543063, 32512386, 32703818, 32814053, 33037310, 33043282
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	10567353
GO:0005783	Component	Endoplasmic reticulum	IGI	17938254
GO:0005796	Component	Golgi lumen	TAS
GO:0005802	Component	Trans-Golgi network	IBA	21873635
GO:0005802	Component	Trans-Golgi network	IDA	14744861
GO:0005886	Component	Plasma membrane	TAS
GO:0006465	Process	Signal peptide processing	IDA	16912035
GO:0006465	Process	Signal peptide processing	TAS
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	TAS
GO:0008233	Function	Peptidase activity	IDA	10526337, 15082773, 15606899, 17938254
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0009986	Component	Cell surface	IDA	16537537
GO:0010008	Component	Endosome membrane	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016485	Process	Protein processing	IBA	21873635
GO:0016485	Process	Protein processing	IDA	9242664, 10526337, 10567353, 14744861, 15606899, 17938254
GO:0016485	Process	Protein processing	IMP	15899807
GO:0016486	Process	Peptide hormone processing	IBA	21873635
GO:0016486	Process	Peptide hormone processing	IDA	9242664
GO:0019058	Process	Viral life cycle	IEP	8940009
GO:0019082	Process	Viral protein processing	TAS
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030140	Component	Trans-Golgi network transport vesicle	IDA	15078902
GO:0030173	Component	Integral component of Golgi membrane	IBA	21873635
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030574	Process	Collagen catabolic process	TAS
GO:0031638	Process	Zymogen activation	IMP	9130696, 11799113
GO:0032374	Process	Regulation of cholesterol transport	IEA
GO:0032455	Process	Nerve growth factor processing	TAS
GO:0032804	Process	Negative regulation of low-density lipoprotein particle receptor catabolic process	IDA	16912035
GO:0032902	Process	Nerve growth factor production	IDA	8615794
GO:0032904	Process	Negative regulation of nerve growth factor production	IDA	10567353
GO:0032911	Process	Negative regulation of transforming growth factor beta1 production	IMP	15899807
GO:0032940	Process	Secretion by cell	IDA	8615794
GO:0042176	Process	Regulation of protein catabolic process	IMP	15899807
GO:0042277	Function	Peptide binding	IDA	8940009
GO:0043043	Process	Peptide biosynthetic process	IDA	8262946
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045121	Component	Membrane raft	IDA	17010968
GO:0046872	Function	Metal ion binding	IEA
GO:0048406	Function	Nerve growth factor binding	IDA	8615794
GO:0051004	Process	Regulation of lipoprotein lipase activity	TAS
GO:0051044	Process	Positive regulation of membrane protein ectodomain proteolysis	IC	17010968
GO:0052548	Process	Regulation of endopeptidase activity	IDA	14744861
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070268	Process	Cornification	TAS
GO:0090472	Process	Dibasic protein processing	IMP	11799113
GO:1901394	Process	Positive regulation of transforming growth factor beta1 activation	IDA	7737999

Other IDs

• MIM: 136950
• HGNC: 8568
• e!Ensembl: ENSG00000140564

Protein

• UniProt ID: P09958
• Protein name: Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)
• Protein function: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548
• PDB: 4OMC, 4OMD, 4RYD, 4Z2A, 5JMO, 5JXG, 5JXH, 5JXI, 5JXJ, 5MIM, 6A8Y, 6EQV, 6EQW, 6EQX, 6HLB, 6HLD, 6HLE, 6HZA, 6HZB, 6HZC, 6HZD, 6YD2, 6YD3, 6YD4, 6YD7, 7LCU, 7O1U, 7O1W, 7O1Y, 7O20, 7O22, 7QXY, 7QXZ, 7QY0, 7QY1, 7QY2, 8B4V, 8B4W, 8B4X, 8OYH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16470	S8_pro-domain	33 → 107	Peptidase S8 pro-domain	Domain
  PF00082	Peptidase_S8	144 → 427	Subtilase family	Domain
  PF01483	P_proprotein	484 → 570	Proprotein convertase P-domain	Family

• Sequence:

  MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
  FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
  QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
  DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
  GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
  DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
  TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
  SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
  ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
  EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
  EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
  SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
  SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
  RGERTAFIKDQSAL

• Sequence length: 794

Pathways

KEGG:

Viral life cycle - HIV-1

Reactome:

Collagen degradation
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Synthesis and processing of ENV and VPU
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs
Uptake and function of anthrax toxins
Formation of the cornified envelope
Assembly of active LPL and LIPC lipase complexes
CD163 mediating an anti-inflammatory response
Amyloid fiber formation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942, 12376462, 12376462, 16316942
Coronary artery disease	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1, Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	23202125, 26343387, 29212778, 23202125
Hypertension	Hypertensive disease	rs13306026, rs13333226	30487518
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	25056061, 28540026, 31268507, 29483656, 26198764, 30285260, 31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		12376462, 16316942
Development disorder	Child Development Disorders, Pervasive		28540026