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P2RY11 (purinergic receptor P2Y11)

Gene

5032

Purinergic receptor P2Y11

P2RY11

P2Y11

19p13.2

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor

Show/Hide all(105)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048698	hsa-miR-99a-5p	CLASH	23622248
MIRT1208994	hsa-miR-1247	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT1208996	hsa-miR-1275	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1208999	hsa-miR-3140-3p	CLIP-seq
MIRT1209000	hsa-miR-3202	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT1209002	hsa-miR-4260	CLIP-seq
MIRT1209003	hsa-miR-4271	CLIP-seq
MIRT1209004	hsa-miR-4525	CLIP-seq
MIRT1209005	hsa-miR-4665-5p	CLIP-seq
MIRT1209006	hsa-miR-4723-5p	CLIP-seq
MIRT1209007	hsa-miR-4725-3p	CLIP-seq
MIRT1209008	hsa-miR-4747-5p	CLIP-seq
MIRT1209009	hsa-miR-4764-5p	CLIP-seq
MIRT1209010	hsa-miR-625	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT2060039	hsa-miR-1231	CLIP-seq
MIRT2060040	hsa-miR-193a-5p	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT2060041	hsa-miR-3170	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT2060042	hsa-miR-342-5p	CLIP-seq
MIRT2060043	hsa-miR-4313	CLIP-seq
MIRT2060044	hsa-miR-4651	CLIP-seq
MIRT2060045	hsa-miR-4664-5p	CLIP-seq
MIRT2060046	hsa-miR-4667-5p	CLIP-seq
MIRT2060047	hsa-miR-4700-5p	CLIP-seq
MIRT2060048	hsa-miR-608	CLIP-seq
MIRT2060049	hsa-miR-615-5p	CLIP-seq
MIRT2060050	hsa-miR-635	CLIP-seq
MIRT2060051	hsa-miR-637	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT1208997	hsa-miR-23a	CLIP-seq
MIRT1208998	hsa-miR-23b	CLIP-seq
MIRT1209001	hsa-miR-323-3p	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2455779	hsa-miR-2467-3p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2060044	hsa-miR-4651	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2060048	hsa-miR-608	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2455788	hsa-miR-885-3p	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2455779	hsa-miR-2467-3p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2060044	hsa-miR-4651	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2060048	hsa-miR-608	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2455788	hsa-miR-885-3p	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2586504	hsa-miR-4684-5p	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq
MIRT1208995	hsa-miR-1273	CLIP-seq
MIRT2686979	hsa-miR-2276	CLIP-seq
MIRT2455778	hsa-miR-2277-5p	CLIP-seq
MIRT2686980	hsa-miR-3064-5p	CLIP-seq
MIRT2455780	hsa-miR-3177-5p	CLIP-seq
MIRT2686981	hsa-miR-3661	CLIP-seq
MIRT2686982	hsa-miR-3934	CLIP-seq
MIRT2455781	hsa-miR-4252	CLIP-seq
MIRT2455782	hsa-miR-4422	CLIP-seq
MIRT2455783	hsa-miR-4497	CLIP-seq
MIRT2455784	hsa-miR-4639-3p	CLIP-seq
MIRT2455785	hsa-miR-4660	CLIP-seq
MIRT2586504	hsa-miR-4684-5p	CLIP-seq
MIRT2455786	hsa-miR-4746-5p	CLIP-seq
MIRT2686983	hsa-miR-552	CLIP-seq
MIRT2686984	hsa-miR-604	CLIP-seq
MIRT2686985	hsa-miR-631	CLIP-seq
MIRT2455787	hsa-miR-646	CLIP-seq
MIRT2686986	hsa-miR-647	CLIP-seq
MIRT2455789	hsa-miR-892a	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IC	18048695
GO:0006952	Process	Defense response	TAS	9405388
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	18048695
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	9405388
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	9405388
GO:0019722	Process	Calcium-mediated signaling	IDA	18048695
GO:0023041	Process	Neuronal signal transduction	IBA	21873635
GO:0023041	Process	Neuronal signal transduction	IDA	18048695
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IDA	18048695
GO:0035589	Process	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA
GO:0038023	Function	Signaling receptor activity	TAS	9405388
GO:0045031	Function	G protein-coupled ATP receptor activity	IBA	21873635
GO:0045031	Function	G protein-coupled ATP receptor activity	IDA	18048695
GO:0071318	Process	Cellular response to ATP	IDA	18048695

MIM	HGNC	e!Ensembl
602697	8540	ENSG00000244165

Protein

UniProt ID

Q96G91

Protein name

P2Y purinoceptor 11 (P2Y11)

Protein function

Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	45 → 297	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRP
WHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFI
TCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNC
SVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTV
AEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPY
VGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATA
APKPSEPQSRELSQ

Sequence length

374

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		G alpha (q) signalling events P2Y receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Narcolepsy	Narcolepsy, Narcolepsy type 1	rs104894574, rs387906655	24204295, 21170044
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Amnesia	Amnesia, Transient Global
Cataplexy	Cataplexy
Hallucinations	Hallucinations
Narcolepsy-cataplexy syndrome	Narcolepsy-Cataplexy Syndrome		21170044, 24204295

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