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OXTR (oxytocin receptor)

Gene

5021

Oxytocin receptor

OXTR

OT-R, OTR

3p25.3

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin rece

Show/Hide all(139)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023713	hsa-miR-1-3p	Microarray	18668037
MIRT1208809	hsa-miR-1270	CLIP-seq
MIRT1208810	hsa-miR-1293	CLIP-seq
MIRT1208811	hsa-miR-1305	CLIP-seq
MIRT1208812	hsa-miR-1915	CLIP-seq
MIRT1208813	hsa-miR-210	CLIP-seq
MIRT1208814	hsa-miR-25	CLIP-seq
MIRT1208815	hsa-miR-29a	CLIP-seq
MIRT1208816	hsa-miR-29b	CLIP-seq
MIRT1208817	hsa-miR-29c	CLIP-seq
MIRT1208818	hsa-miR-3127-5p	CLIP-seq
MIRT1208819	hsa-miR-3168	CLIP-seq
MIRT1208820	hsa-miR-32	CLIP-seq
MIRT1208821	hsa-miR-3200-3p	CLIP-seq
MIRT1208822	hsa-miR-338-3p	CLIP-seq
MIRT1208823	hsa-miR-3529	CLIP-seq
MIRT1208824	hsa-miR-3607-5p	CLIP-seq
MIRT1208825	hsa-miR-363	CLIP-seq
MIRT1208826	hsa-miR-367	CLIP-seq
MIRT1208827	hsa-miR-379	CLIP-seq
MIRT1208828	hsa-miR-3922-5p	CLIP-seq
MIRT1208829	hsa-miR-409-3p	CLIP-seq
MIRT1208830	hsa-miR-4281	CLIP-seq
MIRT1208831	hsa-miR-4310	CLIP-seq
MIRT1208832	hsa-miR-4325	CLIP-seq
MIRT1208833	hsa-miR-4434	CLIP-seq
MIRT1208834	hsa-miR-4436b-3p	CLIP-seq
MIRT1208835	hsa-miR-4451	CLIP-seq
MIRT1208836	hsa-miR-448	CLIP-seq
MIRT1208837	hsa-miR-4483	CLIP-seq
MIRT1208838	hsa-miR-4516	CLIP-seq
MIRT1208839	hsa-miR-4519	CLIP-seq
MIRT1208840	hsa-miR-451b	CLIP-seq
MIRT1208841	hsa-miR-4531	CLIP-seq
MIRT1208842	hsa-miR-4536	CLIP-seq
MIRT1208843	hsa-miR-4635	CLIP-seq
MIRT1208844	hsa-miR-4650-3p	CLIP-seq
MIRT1208845	hsa-miR-4659a-5p	CLIP-seq
MIRT1208846	hsa-miR-4659b-5p	CLIP-seq
MIRT1208847	hsa-miR-4685-5p	CLIP-seq
MIRT1208848	hsa-miR-4754	CLIP-seq
MIRT1208849	hsa-miR-4766-3p	CLIP-seq
MIRT1208850	hsa-miR-4776-3p	CLIP-seq
MIRT1208851	hsa-miR-4778-3p	CLIP-seq
MIRT1208852	hsa-miR-4796-5p	CLIP-seq
MIRT1208853	hsa-miR-496	CLIP-seq
MIRT1208854	hsa-miR-498	CLIP-seq
MIRT1208855	hsa-miR-539	CLIP-seq
MIRT1208856	hsa-miR-576-5p	CLIP-seq
MIRT1208857	hsa-miR-587	CLIP-seq
MIRT1208858	hsa-miR-620	CLIP-seq
MIRT1208859	hsa-miR-9	CLIP-seq
MIRT1208860	hsa-miR-92a	CLIP-seq
MIRT1208861	hsa-miR-92b	CLIP-seq
MIRT1208810	hsa-miR-1293	CLIP-seq
MIRT1208818	hsa-miR-3127-5p	CLIP-seq
MIRT1208823	hsa-miR-3529	CLIP-seq
MIRT1208827	hsa-miR-379	CLIP-seq
MIRT1208835	hsa-miR-4451	CLIP-seq
MIRT1208837	hsa-miR-4483	CLIP-seq
MIRT1208839	hsa-miR-4519	CLIP-seq
MIRT1208842	hsa-miR-4536	CLIP-seq
MIRT1208844	hsa-miR-4650-3p	CLIP-seq
MIRT2060009	hsa-miR-1292	CLIP-seq
MIRT1208810	hsa-miR-1293	CLIP-seq
MIRT2060010	hsa-miR-1303	CLIP-seq
MIRT2060011	hsa-miR-216a	CLIP-seq
MIRT2060012	hsa-miR-3124-3p	CLIP-seq
MIRT1208818	hsa-miR-3127-5p	CLIP-seq
MIRT1208823	hsa-miR-3529	CLIP-seq
MIRT2060013	hsa-miR-3613-3p	CLIP-seq
MIRT2060014	hsa-miR-3655	CLIP-seq
MIRT1208827	hsa-miR-379	CLIP-seq
MIRT2060015	hsa-miR-4289	CLIP-seq
MIRT1208835	hsa-miR-4451	CLIP-seq
MIRT2060016	hsa-miR-4471	CLIP-seq
MIRT1208837	hsa-miR-4483	CLIP-seq
MIRT1208839	hsa-miR-4519	CLIP-seq
MIRT1208842	hsa-miR-4536	CLIP-seq
MIRT1208844	hsa-miR-4650-3p	CLIP-seq
MIRT2060017	hsa-miR-4729	CLIP-seq
MIRT2060018	hsa-miR-511	CLIP-seq
MIRT2060019	hsa-miR-548c-3p	CLIP-seq
MIRT2060020	hsa-miR-578	CLIP-seq
MIRT2060021	hsa-miR-579	CLIP-seq
MIRT1208857	hsa-miR-587	CLIP-seq
MIRT2288315	hsa-miR-1225-5p	CLIP-seq
MIRT1208809	hsa-miR-1270	CLIP-seq
MIRT1208810	hsa-miR-1293	CLIP-seq
MIRT2060010	hsa-miR-1303	CLIP-seq
MIRT2288316	hsa-miR-153	CLIP-seq
MIRT1208818	hsa-miR-3127-5p	CLIP-seq
MIRT2288317	hsa-miR-33a	CLIP-seq
MIRT2288318	hsa-miR-33b	CLIP-seq
MIRT1208823	hsa-miR-3529	CLIP-seq
MIRT2288319	hsa-miR-3692	CLIP-seq
MIRT1208827	hsa-miR-379	CLIP-seq
MIRT2288320	hsa-miR-3940-5p	CLIP-seq
MIRT2288321	hsa-miR-4263	CLIP-seq
MIRT2288322	hsa-miR-4272	CLIP-seq
MIRT2288323	hsa-miR-4307	CLIP-seq
MIRT1208832	hsa-miR-4325	CLIP-seq
MIRT1208833	hsa-miR-4434	CLIP-seq
MIRT2288324	hsa-miR-4436b-5p	CLIP-seq
MIRT1208835	hsa-miR-4451	CLIP-seq
MIRT1208836	hsa-miR-448	CLIP-seq
MIRT1208837	hsa-miR-4483	CLIP-seq
MIRT2288325	hsa-miR-4507	CLIP-seq
MIRT1208838	hsa-miR-4516	CLIP-seq
MIRT1208839	hsa-miR-4519	CLIP-seq
MIRT1208840	hsa-miR-451b	CLIP-seq
MIRT1208841	hsa-miR-4531	CLIP-seq
MIRT1208842	hsa-miR-4536	CLIP-seq
MIRT1208844	hsa-miR-4650-3p	CLIP-seq
MIRT2288326	hsa-miR-4753-3p	CLIP-seq
MIRT1208849	hsa-miR-4766-3p	CLIP-seq
MIRT2288327	hsa-miR-4768-5p	CLIP-seq
MIRT1208851	hsa-miR-4778-3p	CLIP-seq
MIRT2288328	hsa-miR-4780	CLIP-seq
MIRT1208852	hsa-miR-4796-5p	CLIP-seq
MIRT1208855	hsa-miR-539	CLIP-seq
MIRT2288329	hsa-miR-555	CLIP-seq
MIRT1208856	hsa-miR-576-5p	CLIP-seq
MIRT2060021	hsa-miR-579	CLIP-seq
MIRT1208858	hsa-miR-620	CLIP-seq
MIRT2288330	hsa-miR-623	CLIP-seq
MIRT2288331	hsa-miR-635	CLIP-seq
MIRT1208859	hsa-miR-9	CLIP-seq
MIRT1208810	hsa-miR-1293	CLIP-seq
MIRT1208818	hsa-miR-3127-5p	CLIP-seq
MIRT1208823	hsa-miR-3529	CLIP-seq
MIRT1208827	hsa-miR-379	CLIP-seq
MIRT1208829	hsa-miR-409-3p	CLIP-seq
MIRT1208835	hsa-miR-4451	CLIP-seq
MIRT1208837	hsa-miR-4483	CLIP-seq
MIRT1208839	hsa-miR-4519	CLIP-seq
MIRT1208842	hsa-miR-4536	CLIP-seq
MIRT1208844	hsa-miR-4650-3p	CLIP-seq
MIRT2455773	hsa-miR-3942-3p	CLIP-seq

Transcription factors

Show/Hide all(8)

Transcription factor	Regulation	Reference
CEBPB	Activation	21734268
FOS	Unknown	10218980
GABPA	Unknown	10218980
GABPB1	Unknown	10218980
JUN	Unknown	10218980
MAFF	Unknown	10527846
RELA	Activation	21734268
SP1	Unknown	22030357

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001967	Process	Suckling behavior	IEA
GO:0001975	Process	Response to amphetamine	IEA
GO:0001992	Process	Regulation of systemic arterial blood pressure by vasopressin	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004990	Function	Oxytocin receptor activity	IBA	21873635
GO:0005000	Function	Vasopressin receptor activity	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005902	Component	Microvillus	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0006936	Process	Muscle contraction	TAS	1313946
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	1313946
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007507	Process	Heart development	IEA
GO:0007565	Process	Female pregnancy	IBA	21873635
GO:0007595	Process	Lactation	TAS	1313946
GO:0007613	Process	Memory	IEA
GO:0010701	Process	Positive regulation of norepinephrine secretion	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0017046	Function	Peptide hormone binding	IEA
GO:0021537	Process	Telencephalon development	IEA
GO:0030431	Process	Sleep	IEA
GO:0032230	Process	Positive regulation of synaptic transmission, GABAergic	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0034059	Process	Response to anoxia	IEA
GO:0034097	Process	Response to cytokine	IEA
GO:0035176	Process	Social behavior	IEA
GO:0042220	Process	Response to cocaine	IEA
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042493	Process	Response to drug	IEA
GO:0042711	Process	Maternal behavior	IEA
GO:0042713	Process	Sperm ejaculation	IEA
GO:0042755	Process	Eating behavior	IEA
GO:0043434	Process	Response to peptide hormone	IEA
GO:0044849	Process	Estrous cycle	IEA
GO:0045777	Process	Positive regulation of blood pressure	IEA
GO:0045907	Process	Positive regulation of vasoconstriction	IBA	21873635
GO:0048565	Process	Digestive tract development	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	IEA
GO:0060137	Process	Maternal process involved in parturition	IBA	21873635
GO:0060406	Process	Positive regulation of penile erection	IEA
GO:0060455	Process	Negative regulation of gastric acid secretion	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	IEA
GO:0070474	Process	Positive regulation of uterine smooth muscle contraction	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24002032

MIM	HGNC	e!Ensembl
167055	8529	ENSG00000180914

Protein

UniProt ID

P30559

Protein name

Oxytocin receptor (OT-R)

Protein function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

PDB

6TPK , 7QVM , 7RYC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	56 → 329	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACV
LLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVW
DANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGET
SASKKSNSSSFVLSHRSSSQRSCSQPSTA

Sequence length

389

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Oxytocin signaling pathway		Vasopressin-like receptors G alpha (q) signalling events

Associated diseases

Show/Hide Causal Diseases (4)

Causal
Disease name	Disease term	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1452048149, rs370498156, rs756691187, rs1557863430, rs1557863440, rs1557863546, rs769581210, rs202098093, rs1276388879, rs778792467, rs760059077, rs373783340, rs1557867853, rs772572695, rs753214391, rs749270162, rs548226228, rs1557870645, rs1557874046, rs749548928, rs754532606, rs1557901347, rs1557902023, rs1557909572, rs574335012, rs1557909821, rs1372713010, rs561369202, rs1476293577, rs1557910728, rs1557911386, rs375045125, rs998675361, rs1557916296, rs1557935477, rs866632178, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	20832055
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	15288368, 17893705, 21082655, 18207134, 17383819, 15992526
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	17043644
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20196918

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Cognitive disorder	Cognition Disorders		20347913
Mental depression	Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	19515497, 25262417, 24703166, 20708845, 22510359, 20708845, 22510359, 24703166, 25262417, 19515497, 19515497, 21208749
Monosomy 3p25	Chromosome 3, monosomy 3p25		21082655

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