OAS2 (2'-5'-oligoadenylate synthetase 2)

Gene

• Entrez ID: 4939
• Gene name: 2'-5'-oligoadenylate synthetase 2
• Gene symbol: OAS2
• Synonyms: -
• Chromosome: 12
• Chromosome location: 12q24.13
• Summary: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2`-specific nucleotidyl transfer react

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019125	hsa-miR-335-5p	Microarray	18185580
MIRT021817	hsa-miR-132-3p	Microarray	17612493
MIRT025932	hsa-miR-7-5p	Microarray	17612493
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT446533	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446532	hsa-miR-1199-5p	PAR-CLIP	22100165
MIRT446531	hsa-miR-6751-3p	PAR-CLIP	22100165
MIRT446529	hsa-miR-4635	PAR-CLIP	22100165
MIRT446530	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT446528	hsa-miR-2114-3p	PAR-CLIP	22100165
MIRT446527	hsa-miR-6823-3p	PAR-CLIP	22100165
MIRT446526	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446525	hsa-miR-4306	PAR-CLIP	22100165
MIRT446524	hsa-miR-4644	PAR-CLIP	22100165
MIRT446523	hsa-miR-5192	PAR-CLIP	22100165
MIRT446522	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT446521	hsa-miR-573	PAR-CLIP	22100165
MIRT446519	hsa-miR-4531	PAR-CLIP	22100165
MIRT446520	hsa-miR-1270	PAR-CLIP	22100165
MIRT446518	hsa-miR-620	PAR-CLIP	22100165
MIRT756207	hsa-miR-580-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), In situ hybridization	34516354
MIRT1200998	hsa-miR-1202	CLIP-seq
MIRT1200999	hsa-miR-142-3p	CLIP-seq
MIRT1201000	hsa-miR-2467-3p	CLIP-seq
MIRT1201001	hsa-miR-3158-5p	CLIP-seq
MIRT1201002	hsa-miR-3192	CLIP-seq
MIRT1201003	hsa-miR-323b-5p	CLIP-seq
MIRT1201004	hsa-miR-3614-5p	CLIP-seq
MIRT1201005	hsa-miR-3678-3p	CLIP-seq
MIRT1201006	hsa-miR-3972	CLIP-seq
MIRT1201007	hsa-miR-4278	CLIP-seq
MIRT1201008	hsa-miR-4291	CLIP-seq
MIRT1201009	hsa-miR-4314	CLIP-seq
MIRT1201010	hsa-miR-4419a	CLIP-seq
MIRT1201011	hsa-miR-4447	CLIP-seq
MIRT1201012	hsa-miR-4472	CLIP-seq
MIRT1201013	hsa-miR-4488	CLIP-seq
MIRT1201014	hsa-miR-4510	CLIP-seq
MIRT1201015	hsa-miR-4646-5p	CLIP-seq
MIRT1201016	hsa-miR-4697-5p	CLIP-seq
MIRT1201017	hsa-miR-4716-3p	CLIP-seq
MIRT1201018	hsa-miR-4721	CLIP-seq
MIRT1201019	hsa-miR-4727-3p	CLIP-seq
MIRT1201020	hsa-miR-4747-5p	CLIP-seq
MIRT1201021	hsa-miR-4763-5p	CLIP-seq
MIRT1201022	hsa-miR-4779	CLIP-seq
MIRT1201023	hsa-miR-545	CLIP-seq
MIRT1201024	hsa-miR-548ag	CLIP-seq
MIRT1201025	hsa-miR-548ai	CLIP-seq
MIRT1201026	hsa-miR-659	CLIP-seq
MIRT1201027	hsa-miR-668	CLIP-seq
MIRT1201028	hsa-miR-1	CLIP-seq
MIRT1201029	hsa-miR-106a	CLIP-seq
MIRT1201030	hsa-miR-106b	CLIP-seq
MIRT1201031	hsa-miR-1255a	CLIP-seq
MIRT1201032	hsa-miR-1255b	CLIP-seq
MIRT1201033	hsa-miR-142-5p	CLIP-seq
MIRT1201034	hsa-miR-17	CLIP-seq
MIRT1201035	hsa-miR-206	CLIP-seq
MIRT1201036	hsa-miR-20a	CLIP-seq
MIRT1201037	hsa-miR-20b	CLIP-seq
MIRT1201038	hsa-miR-2277-3p	CLIP-seq
MIRT1201039	hsa-miR-3120-3p	CLIP-seq
MIRT1201040	hsa-miR-346	CLIP-seq
MIRT1201041	hsa-miR-3609	CLIP-seq
MIRT1201042	hsa-miR-3647-3p	CLIP-seq
MIRT1201043	hsa-miR-3667-3p	CLIP-seq
MIRT1201044	hsa-miR-3673	CLIP-seq
MIRT1201045	hsa-miR-3675-5p	CLIP-seq
MIRT1201046	hsa-miR-3681	CLIP-seq
MIRT1201047	hsa-miR-3691-5p	CLIP-seq
MIRT1201048	hsa-miR-384	CLIP-seq
MIRT1201049	hsa-miR-4283	CLIP-seq
MIRT1201050	hsa-miR-4288	CLIP-seq
MIRT1201051	hsa-miR-4426	CLIP-seq
MIRT1201052	hsa-miR-4489	CLIP-seq
MIRT1201053	hsa-miR-4522	CLIP-seq
MIRT1201054	hsa-miR-4647	CLIP-seq
MIRT1201055	hsa-miR-4651	CLIP-seq
MIRT1201056	hsa-miR-4654	CLIP-seq
MIRT1201057	hsa-miR-4656	CLIP-seq
MIRT1201058	hsa-miR-4662b	CLIP-seq
MIRT1201059	hsa-miR-4764-5p	CLIP-seq
MIRT1201060	hsa-miR-4765	CLIP-seq
MIRT1201061	hsa-miR-4769-5p	CLIP-seq
MIRT1201062	hsa-miR-4796-3p	CLIP-seq
MIRT1201063	hsa-miR-498	CLIP-seq
MIRT1201064	hsa-miR-519d	CLIP-seq
MIRT1201065	hsa-miR-548ah	CLIP-seq
MIRT1201066	hsa-miR-608	CLIP-seq
MIRT1201067	hsa-miR-613	CLIP-seq
MIRT1201068	hsa-miR-632	CLIP-seq
MIRT1201069	hsa-miR-654-3p	CLIP-seq
MIRT1201070	hsa-miR-93	CLIP-seq
MIRT1556748	hsa-miR-488	CLIP-seq
MIRT2391842	hsa-miR-3170	CLIP-seq
MIRT2391843	hsa-miR-4705	CLIP-seq
MIRT1200998	hsa-miR-1202	CLIP-seq
MIRT2584433	hsa-miR-1229	CLIP-seq
MIRT1201031	hsa-miR-1255a	CLIP-seq
MIRT1201032	hsa-miR-1255b	CLIP-seq
MIRT2584434	hsa-miR-1262	CLIP-seq
MIRT2584435	hsa-miR-1265	CLIP-seq
MIRT2584436	hsa-miR-185	CLIP-seq
MIRT2584437	hsa-miR-219-1-3p	CLIP-seq
MIRT1201038	hsa-miR-2277-3p	CLIP-seq
MIRT1201000	hsa-miR-2467-3p	CLIP-seq
MIRT2584438	hsa-miR-296-3p	CLIP-seq
MIRT2584439	hsa-miR-3064-5p	CLIP-seq
MIRT2584440	hsa-miR-31	CLIP-seq
MIRT1201039	hsa-miR-3120-3p	CLIP-seq
MIRT2584441	hsa-miR-3125	CLIP-seq
MIRT2584442	hsa-miR-3158-3p	CLIP-seq
MIRT1201001	hsa-miR-3158-5p	CLIP-seq
MIRT2584443	hsa-miR-3168	CLIP-seq
MIRT2584444	hsa-miR-3173-3p	CLIP-seq
MIRT2584445	hsa-miR-3200-5p	CLIP-seq
MIRT2584446	hsa-miR-3605-5p	CLIP-seq
MIRT2584447	hsa-miR-3622b-5p	CLIP-seq
MIRT2584448	hsa-miR-3647-5p	CLIP-seq
MIRT2584449	hsa-miR-3652	CLIP-seq
MIRT1201005	hsa-miR-3678-3p	CLIP-seq
MIRT1201047	hsa-miR-3691-5p	CLIP-seq
MIRT2584450	hsa-miR-3714	CLIP-seq
MIRT2584451	hsa-miR-374a	CLIP-seq
MIRT2584452	hsa-miR-374b	CLIP-seq
MIRT2584453	hsa-miR-3916	CLIP-seq
MIRT1201006	hsa-miR-3972	CLIP-seq
MIRT1201008	hsa-miR-4291	CLIP-seq
MIRT2584454	hsa-miR-4303	CLIP-seq
MIRT1201010	hsa-miR-4419a	CLIP-seq
MIRT2584455	hsa-miR-4430	CLIP-seq
MIRT2584456	hsa-miR-4484	CLIP-seq
MIRT2584457	hsa-miR-4505	CLIP-seq
MIRT1201014	hsa-miR-4510	CLIP-seq
MIRT1201053	hsa-miR-4522	CLIP-seq
MIRT2584458	hsa-miR-4523	CLIP-seq
MIRT2584459	hsa-miR-4533	CLIP-seq
MIRT2584460	hsa-miR-4537	CLIP-seq
MIRT2584461	hsa-miR-4645-5p	CLIP-seq
MIRT2584462	hsa-miR-4673	CLIP-seq
MIRT2584463	hsa-miR-4696	CLIP-seq
MIRT2584464	hsa-miR-4700-3p	CLIP-seq
MIRT2584465	hsa-miR-4701-3p	CLIP-seq
MIRT2584466	hsa-miR-4708-3p	CLIP-seq
MIRT2584467	hsa-miR-4709-5p	CLIP-seq
MIRT2584468	hsa-miR-4720-5p	CLIP-seq
MIRT2584469	hsa-miR-4738-3p	CLIP-seq
MIRT1201020	hsa-miR-4747-5p	CLIP-seq
MIRT1201021	hsa-miR-4763-5p	CLIP-seq
MIRT2584470	hsa-miR-4792	CLIP-seq
MIRT2584471	hsa-miR-4797-5p	CLIP-seq
MIRT2584472	hsa-miR-4799-3p	CLIP-seq
MIRT1556748	hsa-miR-488	CLIP-seq
MIRT1201063	hsa-miR-498	CLIP-seq
MIRT1201023	hsa-miR-545	CLIP-seq
MIRT2584473	hsa-miR-548an	CLIP-seq
MIRT2584474	hsa-miR-549	CLIP-seq
MIRT2584475	hsa-miR-555	CLIP-seq
MIRT2584476	hsa-miR-571	CLIP-seq
MIRT2584477	hsa-miR-576-5p	CLIP-seq
MIRT2584478	hsa-miR-604	CLIP-seq
MIRT2584479	hsa-miR-647	CLIP-seq
MIRT1201069	hsa-miR-654-3p	CLIP-seq
MIRT2584480	hsa-miR-671-5p	CLIP-seq
MIRT2584481	hsa-miR-877	CLIP-seq
MIRT2584482	hsa-miR-924	CLIP-seq
MIRT2584483	hsa-miR-940	CLIP-seq
MIRT2584433	hsa-miR-1229	CLIP-seq
MIRT2584435	hsa-miR-1265	CLIP-seq
MIRT2584436	hsa-miR-185	CLIP-seq
MIRT2686755	hsa-miR-214	CLIP-seq
MIRT1201038	hsa-miR-2277-3p	CLIP-seq
MIRT1201000	hsa-miR-2467-3p	CLIP-seq
MIRT2584438	hsa-miR-296-3p	CLIP-seq
MIRT2584439	hsa-miR-3064-5p	CLIP-seq
MIRT2584440	hsa-miR-31	CLIP-seq
MIRT1201039	hsa-miR-3120-3p	CLIP-seq
MIRT2584441	hsa-miR-3125	CLIP-seq
MIRT1201001	hsa-miR-3158-5p	CLIP-seq
MIRT2584443	hsa-miR-3168	CLIP-seq
MIRT2584445	hsa-miR-3200-5p	CLIP-seq
MIRT2584446	hsa-miR-3605-5p	CLIP-seq
MIRT2686756	hsa-miR-3619-5p	CLIP-seq
MIRT2584448	hsa-miR-3647-5p	CLIP-seq
MIRT2584449	hsa-miR-3652	CLIP-seq
MIRT1201005	hsa-miR-3678-3p	CLIP-seq
MIRT2584450	hsa-miR-3714	CLIP-seq
MIRT2584451	hsa-miR-374a	CLIP-seq
MIRT2584452	hsa-miR-374b	CLIP-seq
MIRT2584453	hsa-miR-3916	CLIP-seq
MIRT1201008	hsa-miR-4291	CLIP-seq
MIRT2584454	hsa-miR-4303	CLIP-seq
MIRT1201010	hsa-miR-4419a	CLIP-seq
MIRT2584455	hsa-miR-4430	CLIP-seq
MIRT2584456	hsa-miR-4484	CLIP-seq
MIRT2584457	hsa-miR-4505	CLIP-seq
MIRT1201014	hsa-miR-4510	CLIP-seq
MIRT1201053	hsa-miR-4522	CLIP-seq
MIRT2584459	hsa-miR-4533	CLIP-seq
MIRT2584460	hsa-miR-4537	CLIP-seq
MIRT2584463	hsa-miR-4696	CLIP-seq
MIRT2584466	hsa-miR-4708-3p	CLIP-seq
MIRT2584467	hsa-miR-4709-5p	CLIP-seq
MIRT2584468	hsa-miR-4720-5p	CLIP-seq
MIRT2584469	hsa-miR-4738-3p	CLIP-seq
MIRT1201020	hsa-miR-4747-5p	CLIP-seq
MIRT1201021	hsa-miR-4763-5p	CLIP-seq
MIRT2584470	hsa-miR-4792	CLIP-seq
MIRT2584472	hsa-miR-4799-3p	CLIP-seq
MIRT1556748	hsa-miR-488	CLIP-seq
MIRT1201063	hsa-miR-498	CLIP-seq
MIRT1201023	hsa-miR-545	CLIP-seq
MIRT2584473	hsa-miR-548an	CLIP-seq
MIRT2584474	hsa-miR-549	CLIP-seq
MIRT2584475	hsa-miR-555	CLIP-seq
MIRT2584477	hsa-miR-576-5p	CLIP-seq
MIRT2686757	hsa-miR-592	CLIP-seq
MIRT2686758	hsa-miR-597	CLIP-seq
MIRT2584478	hsa-miR-604	CLIP-seq
MIRT2584479	hsa-miR-647	CLIP-seq
MIRT1201069	hsa-miR-654-3p	CLIP-seq
MIRT2686759	hsa-miR-761	CLIP-seq
MIRT2584481	hsa-miR-877	CLIP-seq
MIRT2686760	hsa-miR-922	CLIP-seq
MIRT2584482	hsa-miR-924	CLIP-seq
MIRT2584483	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IBA	21873635
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IDA	9880569
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IMP	10464285
GO:0003725	Function	Double-stranded RNA binding	IBA	21873635
GO:0003725	Function	Double-stranded RNA binding	IDA	9880569
GO:0003725	Function	Double-stranded RNA binding	IMP	10464285
GO:0005515	Function	Protein binding	IPI	25416956, 31515488
GO:0005524	Function	ATP binding	IMP	10464285
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	2440675
GO:0006401	Process	RNA catabolic process	IEA
GO:0009615	Process	Response to virus	TAS	21142819
GO:0009617	Process	Response to bacterium	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	TAS	2440675
GO:0045071	Process	Negative regulation of viral genome replication	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	19923450
GO:0051607	Process	Defense response to virus	IBA	21873635
GO:0051607	Process	Defense response to virus	ISS
GO:0051607	Process	Defense response to virus	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	ISS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0060700	Process	Regulation of ribonuclease activity	IBA	21873635
GO:1903487	Process	Regulation of lactation	ISS

Other IDs

• MIM: 603350
• HGNC: 8087
• e!Ensembl: ENSG00000111335

Protein

• UniProt ID: P29728
• Protein name: 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)
• Protein function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10421	OAS1_C	154 → 338		Domain
  PF01909	NTP_transf_2	373 → 471	Nucleotidyltransferase domain	Family
  PF10421	OAS1_C	497 → 685		Domain

• Sequence:

  MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIG
  GSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEI
  QKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVC
  FTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKD
  NFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNN
  VSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNK
  CFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKS
  YTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSF
  DVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLK
  DLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVT
  QYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEA
  KEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVNEMFSSRSHRILNNNSKRNF

• Sequence length: 719

Pathways

KEGG:

NOD-like receptor signaling pathway
Hepatitis C
Measles
Influenza A
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Coronavirus disease - COVID-19

Reactome:

Interferon gamma signaling
OAS antiviral response
Interferon alpha/beta signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	27611488

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	22152193