NTSR1 (neurotensin receptor 1)

Gene

• Entrez ID: 4923
• Gene name: Neurotensin receptor 1
• Gene symbol: NTSR1
• Synonyms: NTR
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secre

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017517	hsa-miR-335-5p	Microarray	18185580
MIRT029363	hsa-miR-26b-5p	Microarray	19088304
MIRT1196327	hsa-miR-1231	CLIP-seq
MIRT1196328	hsa-miR-1254	CLIP-seq
MIRT1196329	hsa-miR-1275	CLIP-seq
MIRT1196330	hsa-miR-1293	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196334	hsa-miR-149	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196337	hsa-miR-193a-5p	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT1196341	hsa-miR-3116	CLIP-seq
MIRT1196342	hsa-miR-3120-5p	CLIP-seq
MIRT1196343	hsa-miR-3126-5p	CLIP-seq
MIRT1196344	hsa-miR-3156-5p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT1196347	hsa-miR-3622b-5p	CLIP-seq
MIRT1196348	hsa-miR-3650	CLIP-seq
MIRT1196349	hsa-miR-3677-3p	CLIP-seq
MIRT1196350	hsa-miR-3921	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT1196353	hsa-miR-4253	CLIP-seq
MIRT1196354	hsa-miR-4286	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196356	hsa-miR-4421	CLIP-seq
MIRT1196357	hsa-miR-4440	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT1196359	hsa-miR-4455	CLIP-seq
MIRT1196360	hsa-miR-4466	CLIP-seq
MIRT1196361	hsa-miR-4483	CLIP-seq
MIRT1196362	hsa-miR-4525	CLIP-seq
MIRT1196363	hsa-miR-4653-5p	CLIP-seq
MIRT1196364	hsa-miR-4665-5p	CLIP-seq
MIRT1196365	hsa-miR-4682	CLIP-seq
MIRT1196366	hsa-miR-4699-5p	CLIP-seq
MIRT1196367	hsa-miR-4711-3p	CLIP-seq
MIRT1196368	hsa-miR-4717-5p	CLIP-seq
MIRT1196369	hsa-miR-4723-5p	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT1196371	hsa-miR-4794	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq
MIRT1196373	hsa-miR-541	CLIP-seq
MIRT1196374	hsa-miR-609	CLIP-seq
MIRT1196375	hsa-miR-625	CLIP-seq
MIRT1196376	hsa-miR-637	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT1196378	hsa-miR-654-5p	CLIP-seq
MIRT1196379	hsa-miR-675	CLIP-seq
MIRT1196380	hsa-miR-760	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056965	hsa-miR-3151	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT2056968	hsa-miR-3199	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT2056969	hsa-miR-3919	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT2056973	hsa-miR-4704-3p	CLIP-seq
MIRT2056974	hsa-miR-4747-3p	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056976	hsa-miR-561	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT2056979	hsa-miR-665	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196327	hsa-miR-1231	CLIP-seq
MIRT2285393	hsa-miR-146b-3p	CLIP-seq
MIRT1196334	hsa-miR-149	CLIP-seq
MIRT2285394	hsa-miR-1915	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT1196342	hsa-miR-3120-5p	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056965	hsa-miR-3151	CLIP-seq
MIRT2285395	hsa-miR-3173-5p	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT2285396	hsa-miR-339-5p	CLIP-seq
MIRT2285397	hsa-miR-342-5p	CLIP-seq
MIRT2285398	hsa-miR-3652	CLIP-seq
MIRT2056969	hsa-miR-3919	CLIP-seq
MIRT1196350	hsa-miR-3921	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT2285399	hsa-miR-4265	CLIP-seq
MIRT2285400	hsa-miR-4281	CLIP-seq
MIRT2285401	hsa-miR-4296	CLIP-seq
MIRT2285402	hsa-miR-4322	CLIP-seq
MIRT1196356	hsa-miR-4421	CLIP-seq
MIRT2285403	hsa-miR-4430	CLIP-seq
MIRT2285404	hsa-miR-4447	CLIP-seq
MIRT2285405	hsa-miR-4449	CLIP-seq
MIRT2285406	hsa-miR-4472	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT1196363	hsa-miR-4653-5p	CLIP-seq
MIRT2285407	hsa-miR-4664-5p	CLIP-seq
MIRT1196365	hsa-miR-4682	CLIP-seq
MIRT2285408	hsa-miR-4685-5p	CLIP-seq
MIRT2285409	hsa-miR-4691-3p	CLIP-seq
MIRT1196371	hsa-miR-4794	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2285410	hsa-miR-596	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196380	hsa-miR-760	CLIP-seq
MIRT2285411	hsa-miR-874	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT2583502	hsa-miR-24	CLIP-seq
MIRT2583503	hsa-miR-2467-5p	CLIP-seq
MIRT2583504	hsa-miR-3136-3p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT2583505	hsa-miR-4494	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT2583506	hsa-miR-499a-5p	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT2583502	hsa-miR-24	CLIP-seq
MIRT2583503	hsa-miR-2467-5p	CLIP-seq
MIRT2583504	hsa-miR-3136-3p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT2583505	hsa-miR-4494	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT2583506	hsa-miR-499a-5p	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	IEA
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	IEA
GO:0003254	Process	Regulation of membrane depolarization	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8381365
GO:0005515	Function	Protein binding	IPI	17620610, 23597562, 23624386
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IMP	8381365
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IDA	21725197
GO:0007268	Process	Chemical synaptic transmission	TAS	9763490
GO:0007612	Process	Learning	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IEA
GO:0014049	Process	Positive regulation of glutamate secretion	IEA
GO:0014054	Process	Positive regulation of gamma-aminobutyric acid secretion	IEA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IDA	21725197
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IMP	8381365
GO:0032280	Component	Symmetric synapse	IEA
GO:0033993	Process	Response to lipid	IEA
GO:0042802	Function	Identical protein binding	IPI	17620610
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21725197
GO:0043195	Component	Terminal bouton	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043198	Component	Dendritic shaft	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043576	Process	Regulation of respiratory gaseous exchange	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IDA	21725197
GO:0047485	Function	Protein N-terminus binding	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0051280	Process	Negative regulation of release of sequestered calcium ion into cytosol	IEA
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IEA
GO:0051930	Process	Regulation of sensory perception of pain	IEA
GO:0060732	Process	Positive regulation of inositol phosphate biosynthetic process	IEA
GO:0070779	Process	D-aspartate import across plasma membrane	IEA
GO:0071545	Process	Inositol phosphate catabolic process	IEA
GO:0090238	Process	Positive regulation of arachidonic acid secretion	IEA
GO:0097151	Process	Positive regulation of inhibitory postsynaptic potential	IEA
GO:0098712	Process	L-glutamate import across plasma membrane	IEA
GO:0098900	Process	Regulation of action potential	IEA
GO:2001259	Process	Positive regulation of cation channel activity	IEA

Other IDs

• MIM: 162651
• HGNC: 8039
• e!Ensembl: ENSG00000101188

Protein

• UniProt ID: P30989
• Protein name: Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)
• Protein function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to
• PDB: 2LYW, 6OS9, 6OSA, 6PWC, 6UP7, 7UL2, 8JPB, 8JPC, 8JPF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	80 → 364	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
  YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
  PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
  SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
  TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
  GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
  PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY

• Sequence length: 418

Pathways

KEGG:

Calcium signaling pathway
Neuroactive ligand-receptor interaction

Reactome:

Peptide ligand-binding receptors
G alpha (q) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1452048149, rs370498156, rs756691187, rs1557863430, rs1557863440, rs1557863546, rs769581210, rs202098093, rs1276388879, rs778792467, rs760059077, rs373783340, rs1557867853, rs772572695, rs753214391, rs749270162, rs548226228, rs1557870645, rs1557874046, rs749548928, rs754532606, rs1557901347, rs1557902023, rs1557909572, rs574335012, rs1557909821, rs1372713010, rs561369202, rs1476293577, rs1557910728, rs1557911386, rs375045125, rs998675361, rs1557916296, rs1557935477, rs866632178, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	24781735
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20659557

Unknown
Disease name	Disease term	dbSNP ID	References
Mood disorder	Mood Disorders		22754041