NTS (neurotensin)

Gene

• Entrez ID: 4922
• Gene name: Neurotensin
• Gene symbol: NTS
• Synonyms: NMN-125, NN, NT, NT/N, NTS1
• Chromosome: 12
• Chromosome location: 12q21.31
• Summary: This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. I

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1196318	hsa-miR-181a	CLIP-seq
MIRT1196319	hsa-miR-181b	CLIP-seq
MIRT1196320	hsa-miR-181c	CLIP-seq
MIRT1196321	hsa-miR-181d	CLIP-seq
MIRT1196322	hsa-miR-4262	CLIP-seq
MIRT1196323	hsa-miR-4698	CLIP-seq
MIRT1196324	hsa-miR-4704-3p	CLIP-seq
MIRT1196325	hsa-miR-543	CLIP-seq
MIRT1196326	hsa-miR-587	CLIP-seq
MIRT1196318	hsa-miR-181a	CLIP-seq
MIRT1196319	hsa-miR-181b	CLIP-seq
MIRT1196320	hsa-miR-181c	CLIP-seq
MIRT1196321	hsa-miR-181d	CLIP-seq
MIRT1196322	hsa-miR-4262	CLIP-seq
MIRT1196323	hsa-miR-4698	CLIP-seq
MIRT1196324	hsa-miR-4704-3p	CLIP-seq
MIRT1196325	hsa-miR-543	CLIP-seq
MIRT1196326	hsa-miR-587	CLIP-seq
MIRT1196318	hsa-miR-181a	CLIP-seq
MIRT1196319	hsa-miR-181b	CLIP-seq
MIRT1196320	hsa-miR-181c	CLIP-seq
MIRT1196321	hsa-miR-181d	CLIP-seq
MIRT1196322	hsa-miR-4262	CLIP-seq
MIRT1196323	hsa-miR-4698	CLIP-seq
MIRT1196324	hsa-miR-4704-3p	CLIP-seq
MIRT1196325	hsa-miR-543	CLIP-seq
MIRT1196326	hsa-miR-587	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF1	Unknown	7791794
CREB1	Unknown	7791794
FOS	Unknown	7791794
JUN	Unknown	7791794
JUND	Unknown	7791794
NR2F2	Unknown	21030593

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005184	Function	Neuropeptide hormone activity	IEA
GO:0005515	Function	Protein binding	IPI	17620610, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0007165	Process	Signal transduction	NAS	8954810
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IDA	11294867
GO:0030133	Component	Transport vesicle	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043679	Component	Axon terminus	IBA	21873635
GO:0048018	Function	Receptor ligand activity	IDA	11294867
GO:0071855	Function	Neuropeptide receptor binding	IPI	11294867

Other IDs

• MIM: 162650
• HGNC: 8038
• e!Ensembl: ENSG00000133636

Protein

• UniProt ID: P30990
• Protein name: Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]
• Protein function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
• PDB: 2LNE, 2LNF, 2LNG, 2LYW, 2OYV, 2OYW, 3F6K, 4PO7, 5LUZ, 6UP7, 8VJY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07421	Pro-NT_NN	7 → 170	Neurotensin/neuromedin N precursor	Family

• Sequence:

  MMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLN
  VCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWE
  LIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY

• Sequence length: 170

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Peptide ligand-binding receptors
G alpha (q) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20659557, 23483448, 25449842, 20193696

Unknown
Disease name	Disease term	dbSNP ID	References
Catalepsy	Catalepsy		20882060
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	22754041
Mood disorder	Mood Disorders		22754041