NPY1R (neuropeptide Y receptor Y1)

Gene

• Entrez ID: 4886
• Gene name: Neuropeptide Y receptor Y1
• Gene symbol: NPY1R
• Synonyms: NPY1-R, NPYR
• Chromosome: 4
• Chromosome location: 4q32.2
• Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast ago

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018353	hsa-miR-335-5p	Microarray	18185580
MIRT1191684	hsa-miR-101	CLIP-seq
MIRT1191685	hsa-miR-106a	CLIP-seq
MIRT1191686	hsa-miR-106b	CLIP-seq
MIRT1191687	hsa-miR-1184	CLIP-seq
MIRT1191688	hsa-miR-1193	CLIP-seq
MIRT1191689	hsa-miR-1205	CLIP-seq
MIRT1191690	hsa-miR-1249	CLIP-seq
MIRT1191691	hsa-miR-1264	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT1191693	hsa-miR-1323	CLIP-seq
MIRT1191694	hsa-miR-144	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191698	hsa-miR-153	CLIP-seq
MIRT1191699	hsa-miR-17	CLIP-seq
MIRT1191700	hsa-miR-1911	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191703	hsa-miR-20a	CLIP-seq
MIRT1191704	hsa-miR-20b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191706	hsa-miR-2116	CLIP-seq
MIRT1191707	hsa-miR-218	CLIP-seq
MIRT1191708	hsa-miR-223	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT1191710	hsa-miR-2467-5p	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT1191712	hsa-miR-3065-5p	CLIP-seq
MIRT1191713	hsa-miR-3140-3p	CLIP-seq
MIRT1191714	hsa-miR-3143	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191716	hsa-miR-3158-5p	CLIP-seq
MIRT1191717	hsa-miR-3163	CLIP-seq
MIRT1191718	hsa-miR-3180-5p	CLIP-seq
MIRT1191719	hsa-miR-3188	CLIP-seq
MIRT1191720	hsa-miR-323b-3p	CLIP-seq
MIRT1191721	hsa-miR-3609	CLIP-seq
MIRT1191722	hsa-miR-3619-3p	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191725	hsa-miR-3665	CLIP-seq
MIRT1191726	hsa-miR-3667-5p	CLIP-seq
MIRT1191727	hsa-miR-3682-5p	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT1191729	hsa-miR-375	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191731	hsa-miR-380	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191734	hsa-miR-3975	CLIP-seq
MIRT1191735	hsa-miR-425	CLIP-seq
MIRT1191736	hsa-miR-4273	CLIP-seq
MIRT1191737	hsa-miR-4303	CLIP-seq
MIRT1191738	hsa-miR-431	CLIP-seq
MIRT1191739	hsa-miR-4328	CLIP-seq
MIRT1191740	hsa-miR-433	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT1191742	hsa-miR-4446-5p	CLIP-seq
MIRT1191743	hsa-miR-448	CLIP-seq
MIRT1191744	hsa-miR-4497	CLIP-seq
MIRT1191745	hsa-miR-450b-5p	CLIP-seq
MIRT1191746	hsa-miR-452	CLIP-seq
MIRT1191747	hsa-miR-4633-5p	CLIP-seq
MIRT1191748	hsa-miR-4649-3p	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191750	hsa-miR-4668-3p	CLIP-seq
MIRT1191751	hsa-miR-4676-3p	CLIP-seq
MIRT1191752	hsa-miR-4677-5p	CLIP-seq
MIRT1191753	hsa-miR-4686	CLIP-seq
MIRT1191754	hsa-miR-4704-3p	CLIP-seq
MIRT1191755	hsa-miR-4705	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT1191757	hsa-miR-4719	CLIP-seq
MIRT1191758	hsa-miR-4755-5p	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191760	hsa-miR-4796-3p	CLIP-seq
MIRT1191761	hsa-miR-485-5p	CLIP-seq
MIRT1191762	hsa-miR-488	CLIP-seq
MIRT1191763	hsa-miR-491-3p	CLIP-seq
MIRT1191764	hsa-miR-507	CLIP-seq
MIRT1191765	hsa-miR-513a-3p	CLIP-seq
MIRT1191766	hsa-miR-513b	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191768	hsa-miR-519d	CLIP-seq
MIRT1191769	hsa-miR-520a-5p	CLIP-seq
MIRT1191770	hsa-miR-525-5p	CLIP-seq
MIRT1191771	hsa-miR-532-5p	CLIP-seq
MIRT1191772	hsa-miR-548ah	CLIP-seq
MIRT1191773	hsa-miR-548c-3p	CLIP-seq
MIRT1191774	hsa-miR-548n	CLIP-seq
MIRT1191775	hsa-miR-548o	CLIP-seq
MIRT1191776	hsa-miR-548t	CLIP-seq
MIRT1191777	hsa-miR-549	CLIP-seq
MIRT1191778	hsa-miR-557	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT1191780	hsa-miR-586	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT1191782	hsa-miR-633	CLIP-seq
MIRT1191783	hsa-miR-636	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT1191785	hsa-miR-656	CLIP-seq
MIRT1191786	hsa-miR-657	CLIP-seq
MIRT1191787	hsa-miR-670	CLIP-seq
MIRT1191788	hsa-miR-93	CLIP-seq
MIRT1191789	hsa-miR-935	CLIP-seq
MIRT1191790	hsa-miR-944	CLIP-seq
MIRT1191687	hsa-miR-1184	CLIP-seq
MIRT1191688	hsa-miR-1193	CLIP-seq
MIRT1191689	hsa-miR-1205	CLIP-seq
MIRT2055569	hsa-miR-1207-5p	CLIP-seq
MIRT2055570	hsa-miR-1236	CLIP-seq
MIRT2055571	hsa-miR-1283	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT2055572	hsa-miR-132	CLIP-seq
MIRT2055573	hsa-miR-136	CLIP-seq
MIRT2055574	hsa-miR-141	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191700	hsa-miR-1911	CLIP-seq
MIRT2055575	hsa-miR-1914	CLIP-seq
MIRT2055576	hsa-miR-200a	CLIP-seq
MIRT2055577	hsa-miR-200b	CLIP-seq
MIRT2055578	hsa-miR-200c	CLIP-seq
MIRT2055579	hsa-miR-2054	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191706	hsa-miR-2116	CLIP-seq
MIRT2055580	hsa-miR-212	CLIP-seq
MIRT2055581	hsa-miR-216b	CLIP-seq
MIRT1191708	hsa-miR-223	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT2055582	hsa-miR-3121-5p	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191716	hsa-miR-3158-5p	CLIP-seq
MIRT2055583	hsa-miR-3160-5p	CLIP-seq
MIRT2055584	hsa-miR-3189-3p	CLIP-seq
MIRT2055585	hsa-miR-3189-5p	CLIP-seq
MIRT2055586	hsa-miR-3200-3p	CLIP-seq
MIRT2055587	hsa-miR-3607-3p	CLIP-seq
MIRT2055588	hsa-miR-3616-5p	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT2055589	hsa-miR-3647-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191727	hsa-miR-3682-5p	CLIP-seq
MIRT2055590	hsa-miR-3686	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT2055591	hsa-miR-3689a-3p	CLIP-seq
MIRT2055592	hsa-miR-3689c	CLIP-seq
MIRT2055593	hsa-miR-369-3p	CLIP-seq
MIRT2055594	hsa-miR-374a	CLIP-seq
MIRT2055595	hsa-miR-374b	CLIP-seq
MIRT2055596	hsa-miR-374c	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191731	hsa-miR-380	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191736	hsa-miR-4273	CLIP-seq
MIRT2055597	hsa-miR-429	CLIP-seq
MIRT2055598	hsa-miR-4300	CLIP-seq
MIRT1191738	hsa-miR-431	CLIP-seq
MIRT1191739	hsa-miR-4328	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT2055599	hsa-miR-4426	CLIP-seq
MIRT2055600	hsa-miR-4647	CLIP-seq
MIRT2055601	hsa-miR-4662b	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191752	hsa-miR-4677-5p	CLIP-seq
MIRT1191753	hsa-miR-4686	CLIP-seq
MIRT2055602	hsa-miR-4694-3p	CLIP-seq
MIRT2055603	hsa-miR-4694-5p	CLIP-seq
MIRT1191754	hsa-miR-4704-3p	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT2055604	hsa-miR-4724-5p	CLIP-seq
MIRT2055605	hsa-miR-4729	CLIP-seq
MIRT2055606	hsa-miR-4736	CLIP-seq
MIRT2055607	hsa-miR-4742-3p	CLIP-seq
MIRT2055608	hsa-miR-4758-3p	CLIP-seq
MIRT2055609	hsa-miR-4763-3p	CLIP-seq
MIRT2055610	hsa-miR-4768-5p	CLIP-seq
MIRT2055611	hsa-miR-4773	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191762	hsa-miR-488	CLIP-seq
MIRT2055612	hsa-miR-502-5p	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191771	hsa-miR-532-5p	CLIP-seq
MIRT1191773	hsa-miR-548c-3p	CLIP-seq
MIRT2055613	hsa-miR-558	CLIP-seq
MIRT2055614	hsa-miR-568	CLIP-seq
MIRT2055615	hsa-miR-573	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT2055616	hsa-miR-591	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT2055617	hsa-miR-605	CLIP-seq
MIRT2055618	hsa-miR-622	CLIP-seq
MIRT1191782	hsa-miR-633	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT2055619	hsa-miR-654-3p	CLIP-seq
MIRT2055620	hsa-miR-655	CLIP-seq
MIRT2055621	hsa-miR-920	CLIP-seq
MIRT1191789	hsa-miR-935	CLIP-seq
MIRT2284504	hsa-miR-1231	CLIP-seq
MIRT2055571	hsa-miR-1283	CLIP-seq
MIRT1191692	hsa-miR-1298	CLIP-seq
MIRT1191695	hsa-miR-148a	CLIP-seq
MIRT1191696	hsa-miR-148b	CLIP-seq
MIRT1191697	hsa-miR-152	CLIP-seq
MIRT1191701	hsa-miR-208a	CLIP-seq
MIRT1191702	hsa-miR-208b	CLIP-seq
MIRT1191705	hsa-miR-2113	CLIP-seq
MIRT1191709	hsa-miR-224	CLIP-seq
MIRT2284505	hsa-miR-2392	CLIP-seq
MIRT1191710	hsa-miR-2467-5p	CLIP-seq
MIRT1191711	hsa-miR-300	CLIP-seq
MIRT1191712	hsa-miR-3065-5p	CLIP-seq
MIRT2284506	hsa-miR-3136-3p	CLIP-seq
MIRT1191714	hsa-miR-3143	CLIP-seq
MIRT1191715	hsa-miR-3148	CLIP-seq
MIRT1191719	hsa-miR-3188	CLIP-seq
MIRT1191723	hsa-miR-3622a-5p	CLIP-seq
MIRT1191724	hsa-miR-3662	CLIP-seq
MIRT1191728	hsa-miR-3688-3p	CLIP-seq
MIRT1191730	hsa-miR-377	CLIP-seq
MIRT1191732	hsa-miR-381	CLIP-seq
MIRT1191733	hsa-miR-3912	CLIP-seq
MIRT1191734	hsa-miR-3975	CLIP-seq
MIRT1191735	hsa-miR-425	CLIP-seq
MIRT1191737	hsa-miR-4303	CLIP-seq
MIRT1191740	hsa-miR-433	CLIP-seq
MIRT1191741	hsa-miR-4423-3p	CLIP-seq
MIRT1191747	hsa-miR-4633-5p	CLIP-seq
MIRT1191748	hsa-miR-4649-3p	CLIP-seq
MIRT1191749	hsa-miR-4666-3p	CLIP-seq
MIRT1191755	hsa-miR-4705	CLIP-seq
MIRT1191756	hsa-miR-4718	CLIP-seq
MIRT1191759	hsa-miR-4789-5p	CLIP-seq
MIRT1191761	hsa-miR-485-5p	CLIP-seq
MIRT1191763	hsa-miR-491-3p	CLIP-seq
MIRT1191767	hsa-miR-515-5p	CLIP-seq
MIRT1191777	hsa-miR-549	CLIP-seq
MIRT1191779	hsa-miR-582-5p	CLIP-seq
MIRT1191781	hsa-miR-599	CLIP-seq
MIRT1191784	hsa-miR-642b	CLIP-seq
MIRT2055619	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001601	Function	Peptide YY receptor activity	IEA
GO:0001602	Function	Pancreatic polypeptide receptor activity	IBA	21873635
GO:0003151	Process	Outflow tract morphogenesis	IMP	19593212
GO:0004983	Function	Neuropeptide Y receptor activity	TAS	1317848
GO:0005515	Function	Protein binding	IPI	23597562
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	1317848
GO:0006006	Process	Glucose metabolic process	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1317848
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	1321422
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0007631	Process	Feeding behavior	IEA
GO:0008217	Process	Regulation of blood pressure	IEA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0040014	Process	Regulation of multicellular organism growth	IEA

Other IDs

• MIM: 162641
• HGNC: 7956
• e!Ensembl: ENSG00000164128

Protein

• UniProt ID: P25929
• Protein name: Neuropeptide Y receptor type 1 (NPY1-R)
• Protein function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
• PDB: 5ZBQ, 7VGX, 7X9A, 8K6M, 8K6O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	57 → 320	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
  LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
  CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
  DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
  RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
  LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
  KTSLKQASPVAFKKINNNDDNEKI

• Sequence length: 384

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes

Reactome:

Peptide ligand-binding receptors
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anencephaly	Iniencephaly, Exencephaly	rs773607884	17400914
Neural tube defect	Neural Tube Defects	rs121918220, rs121434297, rs137853061, rs137853062, rs3127334, rs267607167, rs267607168, rs387907204, rs139365610, rs137955120, rs786201015, rs786201016, rs768434408, rs777661576, rs747846362, rs200137991, rs780014899, rs574132670, rs786204013, rs147257424, rs763539350, rs776483190, rs757259023, rs781461462, rs762921297, rs1114167354, rs557643577, rs147277149, rs765586205, rs377443637, rs1563593163, rs1303000329, rs1565818580, rs986604359, rs1293600145, rs114727354, rs146357218, rs768980918, rs140277700, rs139645527, rs750323424, rs368321176, rs1579619636, rs893229476, rs754990692, rs763079713, rs1593037878, rs747100389, rs372056091, rs1593083585, rs778121031, rs748778907, rs776969786, rs1189298981, rs375908206, rs1734858651, rs778738842	17400914
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	20975297
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	14741323, 21512575

Unknown
Disease name	Disease term	dbSNP ID	References
Acrania	Acrania		17400914
Anxiety disorder	Anxiety Disorders, Anxiety States, Neurotic		11440811
Craniorachischisis	Craniorachischisis		17400914
Diastematomyelia	Diastematomyelia		17400914
Melancholia	Melancholia		9729278
Mental depression	Endogenous depression, Depressive disorder, Unipolar Depression, Depressive Syndrome, Depression, Neurotic	rs587778876, rs587778877	9729278
Neurenteric cyst	Neurenteric Cyst		17400914
Nonorganic psychosis	Nonorganic psychosis		19566775
Primary tethered cord syndrome	Tethered Cord Syndrome		17400914
Psychosis	Psychotic Disorders		19566775
Spinal cord myelodysplasia	Spinal Cord Myelodysplasia		17400914