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NPR3 (natriuretic peptide receptor 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4883
Gene nameGene Name - the full gene name approved by the HGNC.
Natriuretic peptide receptor 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NPR3
SynonymsGene synonyms aliases
ANP-C, ANPR-C, ANPRC, BOMOS, C5orf23, GUCY2B, NPR-C, NPRC
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of thi
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005159 hsa-miR-30a-5p pSILAC 18668040
MIRT001435 hsa-miR-16-5p pSILAC 18668040
MIRT017512 hsa-miR-335-5p Microarray 18185580
MIRT027551 hsa-miR-98-5p Microarray 19088304
MIRT005159 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development ISS
GO:0002158 Process Osteoclast proliferation ISS
GO:0005515 Function Protein binding IPI 16870210
GO:0005887 Component Integral component of plasma membrane IC 1660465
GO:0007193 Process Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P17342
Protein name Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)
Protein function Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB
PDB 1JDN , 1JDP , 1YK0 , 1YK1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01094 ANF_receptor
71 425
Receptor family ligand binding region
Family
Sequence
Sequence length 541
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Hormone signaling  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 19208208
Unknown
Disease name Disease term dbSNP ID References
Arachnodactyly Arachnodactyly 10468599
Prostatic neoplasms Prostatic Neoplasms 19208208

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