NPAS2 (neuronal PAS domain protein 2)

Gene

• Entrez ID: 4862
• Gene name: Neuronal PAS domain protein 2
• Gene symbol: NPAS2
• Synonyms: MOP4, PASD4, bHLHe9
• Chromosome: 2
• Chromosome location: 2q11.2
• Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018156	hsa-miR-335-5p	Microarray	18185580
MIRT050815	hsa-miR-17-5p	CLASH	23622248
MIRT042271	hsa-miR-484	CLASH	23622248
MIRT296914	hsa-miR-93-5p	Microarray, qRT-PCR	22815788
MIRT1190291	hsa-miR-103a	CLIP-seq
MIRT1190292	hsa-miR-107	CLIP-seq
MIRT1190293	hsa-miR-1179	CLIP-seq
MIRT1190294	hsa-miR-1229	CLIP-seq
MIRT1190295	hsa-miR-1273f	CLIP-seq
MIRT1190296	hsa-miR-1295	CLIP-seq
MIRT1190297	hsa-miR-1825	CLIP-seq
MIRT1190298	hsa-miR-190	CLIP-seq
MIRT1190299	hsa-miR-190b	CLIP-seq
MIRT1190300	hsa-miR-199a-5p	CLIP-seq
MIRT1190301	hsa-miR-199b-5p	CLIP-seq
MIRT1190302	hsa-miR-296-3p	CLIP-seq
MIRT1190303	hsa-miR-30a	CLIP-seq
MIRT1190304	hsa-miR-30b	CLIP-seq
MIRT1190305	hsa-miR-30c	CLIP-seq
MIRT1190306	hsa-miR-30d	CLIP-seq
MIRT1190307	hsa-miR-30e	CLIP-seq
MIRT1190308	hsa-miR-342-5p	CLIP-seq
MIRT1190309	hsa-miR-3668	CLIP-seq
MIRT1190310	hsa-miR-3674	CLIP-seq
MIRT1190311	hsa-miR-409-5p	CLIP-seq
MIRT1190312	hsa-miR-4264	CLIP-seq
MIRT1190313	hsa-miR-4310	CLIP-seq
MIRT1190314	hsa-miR-4433	CLIP-seq
MIRT1190315	hsa-miR-4528	CLIP-seq
MIRT1190316	hsa-miR-4651	CLIP-seq
MIRT1190317	hsa-miR-4664-5p	CLIP-seq
MIRT1190318	hsa-miR-4684-3p	CLIP-seq
MIRT1190319	hsa-miR-4699-5p	CLIP-seq
MIRT1190320	hsa-miR-4703-3p	CLIP-seq
MIRT1190321	hsa-miR-4717-5p	CLIP-seq
MIRT1190322	hsa-miR-4718	CLIP-seq
MIRT1190323	hsa-miR-4756-3p	CLIP-seq
MIRT1190324	hsa-miR-4766-5p	CLIP-seq
MIRT1190325	hsa-miR-4793-3p	CLIP-seq
MIRT1190326	hsa-miR-4797-3p	CLIP-seq
MIRT1190327	hsa-miR-508-5p	CLIP-seq
MIRT1190328	hsa-miR-520a-5p	CLIP-seq
MIRT1190329	hsa-miR-525-5p	CLIP-seq
MIRT1190330	hsa-miR-556-3p	CLIP-seq
MIRT1190331	hsa-miR-595	CLIP-seq
MIRT1190332	hsa-miR-608	CLIP-seq
MIRT1190333	hsa-miR-629	CLIP-seq
MIRT1190334	hsa-miR-630	CLIP-seq
MIRT1190335	hsa-miR-661	CLIP-seq
MIRT1190336	hsa-miR-665	CLIP-seq
MIRT1551809	hsa-miR-19a	CLIP-seq
MIRT1551810	hsa-miR-19b	CLIP-seq
MIRT2284062	hsa-miR-214	CLIP-seq
MIRT1190303	hsa-miR-30a	CLIP-seq
MIRT1190304	hsa-miR-30b	CLIP-seq
MIRT1190305	hsa-miR-30c	CLIP-seq
MIRT1190306	hsa-miR-30d	CLIP-seq
MIRT1190307	hsa-miR-30e	CLIP-seq
MIRT2284063	hsa-miR-3198	CLIP-seq
MIRT2284064	hsa-miR-3619-5p	CLIP-seq
MIRT2284065	hsa-miR-4291	CLIP-seq
MIRT2284066	hsa-miR-4309	CLIP-seq
MIRT2284067	hsa-miR-432	CLIP-seq
MIRT2284068	hsa-miR-4653-3p	CLIP-seq
MIRT2284069	hsa-miR-499a-5p	CLIP-seq
MIRT2284070	hsa-miR-761	CLIP-seq
MIRT2284071	hsa-miR-890	CLIP-seq
MIRT2284072	hsa-miR-922	CLIP-seq
MIRT2439048	hsa-miR-216a	CLIP-seq
MIRT2439049	hsa-miR-216b	CLIP-seq
MIRT2439050	hsa-miR-4753-3p	CLIP-seq
MIRT2439051	hsa-miR-4768-5p	CLIP-seq
MIRT2439048	hsa-miR-216a	CLIP-seq
MIRT2439049	hsa-miR-216b	CLIP-seq
MIRT2439050	hsa-miR-4753-3p	CLIP-seq
MIRT2439051	hsa-miR-4768-5p	CLIP-seq
MIRT2582179	hsa-miR-1182	CLIP-seq
MIRT2582180	hsa-miR-1207-5p	CLIP-seq
MIRT2582181	hsa-miR-1288	CLIP-seq
MIRT2582182	hsa-miR-2110	CLIP-seq
MIRT2582183	hsa-miR-3144-5p	CLIP-seq
MIRT2582184	hsa-miR-3150a-3p	CLIP-seq
MIRT2582185	hsa-miR-3189-3p	CLIP-seq
MIRT2582186	hsa-miR-3191	CLIP-seq
MIRT2582187	hsa-miR-3199	CLIP-seq
MIRT2582188	hsa-miR-4418	CLIP-seq
MIRT2582189	hsa-miR-4652-5p	CLIP-seq
MIRT2582190	hsa-miR-4736	CLIP-seq
MIRT2582191	hsa-miR-4763-3p	CLIP-seq
MIRT2582192	hsa-miR-509-3-5p	CLIP-seq
MIRT2582193	hsa-miR-509-5p	CLIP-seq
MIRT2582179	hsa-miR-1182	CLIP-seq
MIRT2582180	hsa-miR-1207-5p	CLIP-seq
MIRT2582181	hsa-miR-1288	CLIP-seq
MIRT2582182	hsa-miR-2110	CLIP-seq
MIRT2582183	hsa-miR-3144-5p	CLIP-seq
MIRT2582184	hsa-miR-3150a-3p	CLIP-seq
MIRT2582185	hsa-miR-3189-3p	CLIP-seq
MIRT2582186	hsa-miR-3191	CLIP-seq
MIRT2582187	hsa-miR-3199	CLIP-seq
MIRT2582188	hsa-miR-4418	CLIP-seq
MIRT2582189	hsa-miR-4652-5p	CLIP-seq
MIRT2582190	hsa-miR-4736	CLIP-seq
MIRT2582191	hsa-miR-4763-3p	CLIP-seq
MIRT2582192	hsa-miR-509-3-5p	CLIP-seq
MIRT2582193	hsa-miR-509-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KAT2B	Unknown	14645221

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IDA	11441146
GO:0003677	Function	DNA binding	IPI	9576906
GO:0003700	Function	DNA-binding transcription factor activity	TAS	9012850
GO:0005515	Function	Protein binding	IPI	14645221, 24722188, 28514442, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	14645221
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IPI	9576906
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006974	Process	Cellular response to DNA damage stimulus	IEA
GO:0007417	Process	Central nervous system development	TAS	9012850
GO:0007623	Process	Circadian rhythm	TAS
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0032922	Process	Circadian regulation of gene expression	IBA	21873635
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0042493	Process	Response to drug	ISS
GO:0045739	Process	Positive regulation of DNA repair	IMP	18819933
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	11441146
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	18819933
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	9576906
GO:0046872	Function	Metal ion binding	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0051775	Process	Response to redox state	IDA	11441146
GO:0051879	Function	Hsp90 protein binding	IDA	9079689
GO:0060548	Process	Negative regulation of cell death	IMP	18819933
GO:1990513	Component	CLOCK-BMAL transcription complex	IBA	21873635
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000987	Process	Positive regulation of behavioral fear response	ISS
GO:2001020	Process	Regulation of response to DNA damage stimulus	IMP	18819933

Other IDs

• MIM: 603347
• HGNC: 7895
• e!Ensembl: ENSG00000170485

Protein

• UniProt ID: Q99743
• Protein name: Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)
• Protein function: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	10 → 60	Helix-loop-helix DNA-binding domain	Domain
  PF00989	PAS	84 → 176	PAS fold	Domain
  PF14598	PAS_11	248 → 355		Domain

• Sequence:

  MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
  EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHL
  PSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK
  EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKE
  MCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCH
  QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
  RQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSH
  TAMSEPTSTPTKLMAEASTPALPRSATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLL
  PQTVLQSTPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDS
  NVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLL
  RESSVISTQGPKPMRSSQLMQSSGRSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQC
  QPSPDFSHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPA
  NSSSAPMPVLLMGQAVLHPSFPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLL
  LSTYSQQPGTLGYPQPPPAQPQPLRPPRRVSSLSESSGLQQPPR

• Sequence length: 824

Pathways

KEGG:

Circadian rhythm

Reactome:

BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Circadian Clock

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	17264841
Non-obstructive azoospermia	Non-obstructive azoospermia	rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19839995

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20072116, 16528748, 21835597, 24389266, 22538398
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	19693801, 19693801, 22538398
Schizoaffective disorder	Schizoaffective Disorder		19839995
Seasonal affective disorder	Seasonal Affective Disorder		21835597, 22538398, 22137330, 17969870