Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
4800 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Nuclear transcription factor Y subunit alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
NFYA |
SynonymsGene synonyms aliases
|
CBF-A, CBF-B, HAP2, NF-YA |
ChromosomeChromosome number
|
6 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6p21.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000976 |
Function |
Transcription regulatory region sequence-specific DNA binding |
IDA |
11256944 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA |
11256944 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
ISS |
|
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0003677 |
Function |
DNA binding |
IDA |
15243141 |
GO:0003700 |
Function |
DNA-binding transcription factor activity |
TAS |
1774067, 2000400 |
GO:0005515 |
Function |
Protein binding |
IPI |
10571058, 12659632, 12741956, 15243141, 16189514, 16959611, 19060904, 20936779, 23332751, 25416956, 29892012, 31515488 |
GO:0005634 |
Component |
Nucleus |
IDA |
15243141, 15964792 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
IDA |
15243141 |
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0006366 |
Process |
Transcription by RNA polymerase II |
TAS |
2000400 |
GO:0016602 |
Component |
CCAAT-binding factor complex |
IBA |
21873635 |
GO:0016602 |
Component |
CCAAT-binding factor complex |
IDA |
15243141 |
GO:0032993 |
Component |
Protein-DNA complex |
IDA |
11256944 |
GO:0045540 |
Process |
Regulation of cholesterol biosynthetic process |
TAS |
|
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
ISS |
|
GO:0048511 |
Process |
Rhythmic process |
IEA |
|
GO:0090575 |
Component |
RNA polymerase II transcription regulator complex |
IDA |
11256944 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P23511 |
Protein name |
Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) |
Protein function |
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on |
PDB |
4AWL
,
6QMP
,
6QMQ
,
6QMS
,
8QU2
,
8QU3
,
8QU4
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02045 |
CBFB_NFYA |
263 → 318 |
CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B |
Family |
|
Sequence |
MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPL MVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAV QVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTIL QQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMV PGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLH ESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS
|
|
Sequence length |
347 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Leukemia |
Leukemia, Myelocytic, Acute |
rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 |
27903959 |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
16271038 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Lung neoplasms |
Lung Neoplasms |
|
16271038 |
|