NFKBIE (NFKB inhibitor epsilon)

Gene

• Entrez ID: 4794
• Gene name: NFKB inhibitor epsilon
• Gene symbol: NFKBIE
• Synonyms: IKBE
• Chromosome: 6
• Chromosome location: 6p21.1
• Summary: The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, w

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029491	hsa-miR-26b-5p	Microarray	19088304
MIRT036677	hsa-miR-935	CLASH	23622248
MIRT1183556	hsa-miR-1182	CLIP-seq
MIRT1183557	hsa-miR-1287	CLIP-seq
MIRT1183558	hsa-miR-3135b	CLIP-seq
MIRT1183559	hsa-miR-3154	CLIP-seq
MIRT1183560	hsa-miR-3919	CLIP-seq
MIRT1183561	hsa-miR-409-5p	CLIP-seq
MIRT1183562	hsa-miR-412	CLIP-seq
MIRT1183563	hsa-miR-4292	CLIP-seq
MIRT1183564	hsa-miR-4308	CLIP-seq
MIRT1183565	hsa-miR-4438	CLIP-seq
MIRT1183566	hsa-miR-4470	CLIP-seq
MIRT1183567	hsa-miR-4638-3p	CLIP-seq
MIRT2053221	hsa-miR-942	CLIP-seq
MIRT2282495	hsa-miR-103b	CLIP-seq
MIRT2282496	hsa-miR-1184	CLIP-seq
MIRT2282497	hsa-miR-1185	CLIP-seq
MIRT2282498	hsa-miR-1233	CLIP-seq
MIRT2282499	hsa-miR-125a-5p	CLIP-seq
MIRT2282500	hsa-miR-125b	CLIP-seq
MIRT2282501	hsa-miR-2355-5p	CLIP-seq
MIRT2282502	hsa-miR-296-5p	CLIP-seq
MIRT2282503	hsa-miR-3136-3p	CLIP-seq
MIRT2282504	hsa-miR-3605-5p	CLIP-seq
MIRT2282505	hsa-miR-3679-5p	CLIP-seq
MIRT2282506	hsa-miR-4293	CLIP-seq
MIRT2282507	hsa-miR-4319	CLIP-seq
MIRT2282508	hsa-miR-4418	CLIP-seq
MIRT2282509	hsa-miR-4436b-3p	CLIP-seq
MIRT2282510	hsa-miR-4661-3p	CLIP-seq
MIRT2282511	hsa-miR-4761-3p	CLIP-seq
MIRT2282512	hsa-miR-509-3-5p	CLIP-seq
MIRT2282513	hsa-miR-509-5p	CLIP-seq
MIRT2282514	hsa-miR-544b	CLIP-seq
MIRT2282515	hsa-miR-596	CLIP-seq
MIRT2282516	hsa-miR-661	CLIP-seq
MIRT2455115	hsa-miR-3155	CLIP-seq
MIRT2455116	hsa-miR-3155b	CLIP-seq
MIRT2455117	hsa-miR-3176	CLIP-seq
MIRT2455118	hsa-miR-3922-3p	CLIP-seq
MIRT2455119	hsa-miR-4701-5p	CLIP-seq
MIRT2455120	hsa-miR-484	CLIP-seq
MIRT2455121	hsa-miR-588	CLIP-seq
MIRT2455122	hsa-miR-760	CLIP-seq
MIRT2686247	hsa-miR-1236	CLIP-seq
MIRT2686248	hsa-miR-1470	CLIP-seq
MIRT2686249	hsa-miR-193a-3p	CLIP-seq
MIRT2686250	hsa-miR-193b	CLIP-seq
MIRT2686251	hsa-miR-2114	CLIP-seq
MIRT2686252	hsa-miR-24	CLIP-seq
MIRT2686253	hsa-miR-3064-5p	CLIP-seq
MIRT2455115	hsa-miR-3155	CLIP-seq
MIRT2455116	hsa-miR-3155b	CLIP-seq
MIRT2686254	hsa-miR-3169	CLIP-seq
MIRT2455117	hsa-miR-3176	CLIP-seq
MIRT2686255	hsa-miR-3652	CLIP-seq
MIRT2686256	hsa-miR-3664-3p	CLIP-seq
MIRT2455118	hsa-miR-3922-3p	CLIP-seq
MIRT2686257	hsa-miR-4274	CLIP-seq
MIRT2686258	hsa-miR-4430	CLIP-seq
MIRT2686259	hsa-miR-4436a	CLIP-seq
MIRT2686260	hsa-miR-4436b-5p	CLIP-seq
MIRT2686261	hsa-miR-4505	CLIP-seq
MIRT2686262	hsa-miR-4638-5p	CLIP-seq
MIRT2686263	hsa-miR-4667-3p	CLIP-seq
MIRT2455119	hsa-miR-4701-5p	CLIP-seq
MIRT2455120	hsa-miR-484	CLIP-seq
MIRT2455121	hsa-miR-588	CLIP-seq
MIRT2455122	hsa-miR-760	CLIP-seq
MIRT2686264	hsa-miR-892b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	14743216, 16769727, 21988832, 28514442
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	TAS	9135156
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0042942	Process	D-serine transport	IEA
GO:0042994	Process	Cytoplasmic sequestering of transcription factor	TAS	9135156
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 604548
• HGNC: 7799
• e!Ensembl: ENSG00000146232

Protein

• UniProt ID: O00221
• Protein name: NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
• Protein function: Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00023	Ank	403 → 434	Ankyrin repeat	Repeat

• Sequence:

  MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRG
  GGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAAR
  RSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPS
  DGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPH
  VGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHL
  AVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHS
  LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLV
  QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEES
  LVLLPFDDLKISGKLLLCTD

• Sequence length: 500

Pathways

KEGG:

Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Adipocytokine signaling pathway
Epstein-Barr virus infection
PD-L1 expression and PD-1 checkpoint pathway in cancer

Reactome:

Activation of NF-kappaB in B cells

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	26343386
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	23028356, 22446963

Unknown
Disease name	Disease term	dbSNP ID	References
Lymphocytic leukemia	Chronic Lymphocytic Leukemia