ATOX1 (antioxidant 1 copper chaperone)

Gene

• Entrez ID: 475
• Gene name: Antioxidant 1 copper chaperone
• Gene symbol: ATOX1
• Synonyms: ATX1, HAH1
• Chromosome: 5
• Chromosome location: 5q33.1
• Summary: This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028597	hsa-miR-30a-5p	Proteomics	18668040
MIRT031845	hsa-miR-16-5p	Sequencing	20371350
MIRT051900	hsa-let-7b-5p	CLASH	23622248
MIRT572382	hsa-miR-4476	PAR-CLIP	20371350
MIRT572381	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT572380	hsa-miR-9500	PAR-CLIP	20371350
MIRT572379	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT572378	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT572377	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT572376	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT572375	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT572374	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT572373	hsa-miR-6132	PAR-CLIP	20371350
MIRT572372	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572371	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572370	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572368	hsa-miR-4533	PAR-CLIP	20371350
MIRT572369	hsa-miR-137	PAR-CLIP	20371350
MIRT572367	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572366	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT572382	hsa-miR-4476	PAR-CLIP	20371350
MIRT572381	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT572380	hsa-miR-9500	PAR-CLIP	20371350
MIRT572379	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT572378	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT572377	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT572376	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT572375	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT572374	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT572373	hsa-miR-6132	PAR-CLIP	20371350
MIRT572372	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572371	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572370	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572368	hsa-miR-4533	PAR-CLIP	20371350
MIRT572369	hsa-miR-137	PAR-CLIP	20371350
MIRT572367	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572366	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT806236	hsa-miR-1913	CLIP-seq
MIRT806237	hsa-miR-25	CLIP-seq
MIRT806238	hsa-miR-3065-5p	CLIP-seq
MIRT806239	hsa-miR-32	CLIP-seq
MIRT806240	hsa-miR-324-3p	CLIP-seq
MIRT806241	hsa-miR-363	CLIP-seq
MIRT806242	hsa-miR-367	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT806244	hsa-miR-4313	CLIP-seq
MIRT806245	hsa-miR-4722-3p	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT806247	hsa-miR-646	CLIP-seq
MIRT806248	hsa-miR-9	CLIP-seq
MIRT806249	hsa-miR-92a	CLIP-seq
MIRT806250	hsa-miR-92b	CLIP-seq
MIRT2177572	hsa-miR-1182	CLIP-seq
MIRT2177573	hsa-miR-3591-3p	CLIP-seq
MIRT2177574	hsa-miR-3691-3p	CLIP-seq
MIRT2177575	hsa-miR-4304	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT2177576	hsa-miR-4480	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT2177577	hsa-miR-549	CLIP-seq
MIRT2177578	hsa-miR-873	CLIP-seq
MIRT2177579	hsa-miR-941	CLIP-seq
MIRT2480967	hsa-miR-1231	CLIP-seq
MIRT2480968	hsa-miR-1299	CLIP-seq
MIRT2480969	hsa-miR-133a	CLIP-seq
MIRT2480970	hsa-miR-133b	CLIP-seq
MIRT2480971	hsa-miR-1587	CLIP-seq
MIRT806236	hsa-miR-1913	CLIP-seq
MIRT2480972	hsa-miR-1914	CLIP-seq
MIRT2480973	hsa-miR-1915	CLIP-seq
MIRT2480974	hsa-miR-3120-5p	CLIP-seq
MIRT2480975	hsa-miR-3144-5p	CLIP-seq
MIRT2480976	hsa-miR-3151	CLIP-seq
MIRT2480977	hsa-miR-3191	CLIP-seq
MIRT806240	hsa-miR-324-3p	CLIP-seq
MIRT2177574	hsa-miR-3691-3p	CLIP-seq
MIRT2480978	hsa-miR-4265	CLIP-seq
MIRT2480979	hsa-miR-4296	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT806244	hsa-miR-4313	CLIP-seq
MIRT2480980	hsa-miR-4322	CLIP-seq
MIRT2480981	hsa-miR-4417	CLIP-seq
MIRT2480982	hsa-miR-4447	CLIP-seq
MIRT2480983	hsa-miR-4472	CLIP-seq
MIRT2177576	hsa-miR-4480	CLIP-seq
MIRT2480984	hsa-miR-4492	CLIP-seq
MIRT2480985	hsa-miR-4498	CLIP-seq
MIRT2480986	hsa-miR-4652-5p	CLIP-seq
MIRT2480987	hsa-miR-4656	CLIP-seq
MIRT2480988	hsa-miR-4675	CLIP-seq
MIRT806245	hsa-miR-4722-3p	CLIP-seq
MIRT2480989	hsa-miR-4726-3p	CLIP-seq
MIRT2480990	hsa-miR-4741	CLIP-seq
MIRT2480991	hsa-miR-4786-3p	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT2480992	hsa-miR-491-5p	CLIP-seq
MIRT2480993	hsa-miR-671-5p	CLIP-seq
MIRT2480994	hsa-miR-762	CLIP-seq
MIRT2480995	hsa-miR-875-3p	CLIP-seq
MIRT806248	hsa-miR-9	CLIP-seq
MIRT2480967	hsa-miR-1231	CLIP-seq
MIRT2480968	hsa-miR-1299	CLIP-seq
MIRT2480969	hsa-miR-133a	CLIP-seq
MIRT2480970	hsa-miR-133b	CLIP-seq
MIRT2480971	hsa-miR-1587	CLIP-seq
MIRT806236	hsa-miR-1913	CLIP-seq
MIRT2480972	hsa-miR-1914	CLIP-seq
MIRT2480973	hsa-miR-1915	CLIP-seq
MIRT2480974	hsa-miR-3120-5p	CLIP-seq
MIRT2480975	hsa-miR-3144-5p	CLIP-seq
MIRT2480976	hsa-miR-3151	CLIP-seq
MIRT2480977	hsa-miR-3191	CLIP-seq
MIRT806240	hsa-miR-324-3p	CLIP-seq
MIRT2177574	hsa-miR-3691-3p	CLIP-seq
MIRT2480978	hsa-miR-4265	CLIP-seq
MIRT2480979	hsa-miR-4296	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT806244	hsa-miR-4313	CLIP-seq
MIRT2480980	hsa-miR-4322	CLIP-seq
MIRT2480981	hsa-miR-4417	CLIP-seq
MIRT2480982	hsa-miR-4447	CLIP-seq
MIRT2480983	hsa-miR-4472	CLIP-seq
MIRT2177576	hsa-miR-4480	CLIP-seq
MIRT2480984	hsa-miR-4492	CLIP-seq
MIRT2480985	hsa-miR-4498	CLIP-seq
MIRT2480986	hsa-miR-4652-5p	CLIP-seq
MIRT2480987	hsa-miR-4656	CLIP-seq
MIRT2480988	hsa-miR-4675	CLIP-seq
MIRT806245	hsa-miR-4722-3p	CLIP-seq
MIRT2480989	hsa-miR-4726-3p	CLIP-seq
MIRT2480990	hsa-miR-4741	CLIP-seq
MIRT2480991	hsa-miR-4786-3p	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT2480992	hsa-miR-491-5p	CLIP-seq
MIRT2480993	hsa-miR-671-5p	CLIP-seq
MIRT2480994	hsa-miR-762	CLIP-seq
MIRT2480995	hsa-miR-875-3p	CLIP-seq
MIRT806248	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IDA	12029094
GO:0005515	Function	Protein binding	IPI	12968035, 21667063, 25416956, 32296183
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS	12029094
GO:0006825	Process	Copper ion transport	TAS	15670166
GO:0006878	Process	Cellular copper ion homeostasis	IBA	21873635
GO:0006979	Process	Response to oxidative stress	IBA	21873635
GO:0016530	Function	Metallochaperone activity	TAS	15670166
GO:0016531	Function	Copper chaperone activity	IBA	21873635
GO:0016531	Function	Copper chaperone activity	IDA	12029094
GO:0032767	Function	Copper-dependent protein binding	IPI	10497213

Other IDs

• MIM: 602270
• HGNC: 798
• e!Ensembl: ENSG00000177556

Protein

• UniProt ID: O00244
• Protein name: Copper transport protein ATOX1 (Metal transport protein ATX1)
• Protein function: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
• PDB: 1FE0, 1FE4, 1FEE, 1TL4, 1TL5, 2K1R, 2LQ9, 3CJK, 3IWL, 3IWX, 4QOT, 4YDX, 4YEA, 5F0W, 5T7L, 7DC1, 7ZC3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00403	HMA	5 → 61	Heavy-metal-associated domain	Domain

• Sequence:

  MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGK
  TVSYLGLE

• Sequence length: 68

Pathways

KEGG:

Mineral absorption

Reactome:

Ion influx/efflux at host-pathogen interface

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypertension	Hypertensive disease	rs13306026, rs13333226	22753205
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	23624903

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		23624903