LRRC18 (leucine rich repeat containing 18)

Gene

• Entrez ID: 474354
• Gene name: Leucine rich repeat containing 18
• Gene symbol: LRRC18
• Synonyms: UNQ933, UNQ9338, VKGE9338
• Chromosome: 10
• Chromosome location: 10q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1118996	hsa-miR-1321	CLIP-seq
MIRT1118997	hsa-miR-3150b-3p	CLIP-seq
MIRT1118998	hsa-miR-3165	CLIP-seq
MIRT1118999	hsa-miR-3179	CLIP-seq
MIRT1119000	hsa-miR-3190	CLIP-seq
MIRT1119001	hsa-miR-3202	CLIP-seq
MIRT1119002	hsa-miR-3689d	CLIP-seq
MIRT1119003	hsa-miR-4419a	CLIP-seq
MIRT1119004	hsa-miR-4436b-5p	CLIP-seq
MIRT1119005	hsa-miR-4480	CLIP-seq
MIRT1119006	hsa-miR-4510	CLIP-seq
MIRT1119007	hsa-miR-4533	CLIP-seq
MIRT1119008	hsa-miR-4739	CLIP-seq
MIRT1119009	hsa-miR-4756-5p	CLIP-seq
MIRT1119010	hsa-miR-4784	CLIP-seq
MIRT1119011	hsa-miR-939	CLIP-seq
MIRT1920599	hsa-miR-193a-3p	CLIP-seq
MIRT1920600	hsa-miR-193b	CLIP-seq
MIRT1920601	hsa-miR-513a-3p	CLIP-seq
MIRT1920602	hsa-miR-892b	CLIP-seq
MIRT1920599	hsa-miR-193a-3p	CLIP-seq
MIRT1920600	hsa-miR-193b	CLIP-seq
MIRT1920601	hsa-miR-513a-3p	CLIP-seq
MIRT1920602	hsa-miR-892b	CLIP-seq
MIRT1920599	hsa-miR-193a-3p	CLIP-seq
MIRT1920600	hsa-miR-193b	CLIP-seq
MIRT1920601	hsa-miR-513a-3p	CLIP-seq
MIRT1920602	hsa-miR-892b	CLIP-seq
MIRT2033669	hsa-miR-759	CLIP-seq
MIRT1118998	hsa-miR-3165	CLIP-seq
MIRT1118999	hsa-miR-3179	CLIP-seq
MIRT1119000	hsa-miR-3190	CLIP-seq
MIRT1119001	hsa-miR-3202	CLIP-seq
MIRT1119004	hsa-miR-4436b-5p	CLIP-seq
MIRT1119007	hsa-miR-4533	CLIP-seq
MIRT2453322	hsa-miR-3074-3p	CLIP-seq
MIRT1118998	hsa-miR-3165	CLIP-seq
MIRT1118999	hsa-miR-3179	CLIP-seq
MIRT1119000	hsa-miR-3190	CLIP-seq
MIRT1119001	hsa-miR-3202	CLIP-seq
MIRT2453323	hsa-miR-365	CLIP-seq
MIRT1119004	hsa-miR-4436b-5p	CLIP-seq
MIRT1119007	hsa-miR-4533	CLIP-seq
MIRT2684180	hsa-miR-216a	CLIP-seq
MIRT2684181	hsa-miR-4450	CLIP-seq
MIRT2684182	hsa-miR-4667-5p	CLIP-seq
MIRT2684183	hsa-miR-4700-5p	CLIP-seq
MIRT2684184	hsa-miR-4762-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA

Other IDs

• MIM: 619002
• HGNC: 23199
• e!Ensembl: ENSG00000165383

Protein

• UniProt ID: Q8N456
• Protein name: Leucine-rich repeat-containing protein 18
• Protein function: May be involved in the regulation of spermatogenesis and sperm maturation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	30 → 85	Leucine rich repeat	Repeat
  PF13855	LRR_8	50 → 108	Leucine rich repeat	Repeat
  PF13855	LRR_8	73 → 133	Leucine rich repeat	Repeat

• Sequence:

  MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRN
  LIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL
  KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP
  KPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNL
  ISPNSMAKDSWEDWRIRLTSS

• Sequence length: 261

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	19503088

Unknown
Disease name	Disease term	dbSNP ID	References
Lupus erythematosus	Lupus Erythematosus, Systemic		19838193