NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)

Gene

• Entrez ID: 4702
• Gene name: NADH:ubiquinone oxidoreductase subunit A8
• Gene symbol: NDUFA8
• Synonyms: CI-19KD, CI-PGIV, MC1DN37, PGIV
• Chromosome: 9
• Chromosome location: 9q33.2
• Summary: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1178876	hsa-miR-224	CLIP-seq
MIRT1178877	hsa-miR-3691-3p	CLIP-seq
MIRT1178878	hsa-miR-4265	CLIP-seq
MIRT1178879	hsa-miR-4296	CLIP-seq
MIRT1178880	hsa-miR-4322	CLIP-seq
MIRT1178881	hsa-miR-4417	CLIP-seq
MIRT1178882	hsa-miR-4480	CLIP-seq
MIRT1178883	hsa-miR-4520a-3p	CLIP-seq
MIRT1178884	hsa-miR-4640-5p	CLIP-seq
MIRT1178885	hsa-miR-4726-5p	CLIP-seq
MIRT1178886	hsa-miR-522	CLIP-seq
MIRT1178887	hsa-miR-574-5p	CLIP-seq
MIRT1178888	hsa-miR-711	CLIP-seq
MIRT2051750	hsa-miR-129-5p	CLIP-seq
MIRT2051751	hsa-miR-2053	CLIP-seq
MIRT1178876	hsa-miR-224	CLIP-seq
MIRT1178877	hsa-miR-3691-3p	CLIP-seq
MIRT2051752	hsa-miR-409-3p	CLIP-seq
MIRT1178882	hsa-miR-4480	CLIP-seq
MIRT2051753	hsa-miR-569	CLIP-seq
MIRT2051750	hsa-miR-129-5p	CLIP-seq
MIRT2051751	hsa-miR-2053	CLIP-seq
MIRT1178876	hsa-miR-224	CLIP-seq
MIRT2280852	hsa-miR-3133	CLIP-seq
MIRT1178877	hsa-miR-3691-3p	CLIP-seq
MIRT2051752	hsa-miR-409-3p	CLIP-seq
MIRT1178882	hsa-miR-4480	CLIP-seq
MIRT2051753	hsa-miR-569	CLIP-seq
MIRT2280853	hsa-miR-603	CLIP-seq
MIRT2280854	hsa-miR-758	CLIP-seq
MIRT2391465	hsa-miR-1231	CLIP-seq
MIRT2391466	hsa-miR-1268	CLIP-seq
MIRT2391467	hsa-miR-1268b	CLIP-seq
MIRT2391468	hsa-miR-3663-3p	CLIP-seq
MIRT2391469	hsa-miR-4288	CLIP-seq
MIRT2391470	hsa-miR-4303	CLIP-seq
MIRT2391471	hsa-miR-585	CLIP-seq
MIRT2391472	hsa-miR-632	CLIP-seq
MIRT2051750	hsa-miR-129-5p	CLIP-seq
MIRT2051751	hsa-miR-2053	CLIP-seq
MIRT2051752	hsa-miR-409-3p	CLIP-seq
MIRT2051753	hsa-miR-569	CLIP-seq
MIRT2280854	hsa-miR-758	CLIP-seq
MIRT2051750	hsa-miR-129-5p	CLIP-seq
MIRT2051751	hsa-miR-2053	CLIP-seq
MIRT2051752	hsa-miR-409-3p	CLIP-seq
MIRT2051753	hsa-miR-569	CLIP-seq
MIRT2280854	hsa-miR-758	CLIP-seq
MIRT2051750	hsa-miR-129-5p	CLIP-seq
MIRT2051751	hsa-miR-2053	CLIP-seq
MIRT1178876	hsa-miR-224	CLIP-seq
MIRT1178877	hsa-miR-3691-3p	CLIP-seq
MIRT2051752	hsa-miR-409-3p	CLIP-seq
MIRT1178882	hsa-miR-4480	CLIP-seq
MIRT2051753	hsa-miR-569	CLIP-seq
MIRT2280854	hsa-miR-758	CLIP-seq
MIRT2051750	hsa-miR-129-5p	CLIP-seq
MIRT2051751	hsa-miR-2053	CLIP-seq
MIRT1178876	hsa-miR-224	CLIP-seq
MIRT1178877	hsa-miR-3691-3p	CLIP-seq
MIRT2051752	hsa-miR-409-3p	CLIP-seq
MIRT1178882	hsa-miR-4480	CLIP-seq
MIRT2051753	hsa-miR-569	CLIP-seq
MIRT2280854	hsa-miR-758	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21310150, 27499296, 32814053
GO:0005739	Component	Mitochondrion	IDA	23676665
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005747	Component	Mitochondrial respiratory chain complex I	IBA	21873635
GO:0005747	Component	Mitochondrial respiratory chain complex I	IDA	12611891, 27626371
GO:0005747	Component	Mitochondrial respiratory chain complex I	NAS	9878551
GO:0005758	Component	Mitochondrial intermembrane space	IDA	21310150
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	NAS	9878551
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	TAS
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	NAS	9878551
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IMP	27626371
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	TAS
GO:0044877	Function	Protein-containing complex binding	IDA	23209302

Other IDs

• MIM: 603359
• HGNC: 7692
• e!Ensembl: ENSG00000119421

Protein

• UniProt ID: P51970
• Protein name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
• Protein function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). Complex I functions in the transfer of electr
• PDB: 5XTC, 5XTD, 5XTH, 5XTI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06747	CHCH	78 → 113	CHCH domain	Domain

• Sequence:

  MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEG
  KLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRP
  DLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK

• Sequence length: 172

Pathways

KEGG:

Oxidative phosphorylation
Metabolic pathways
Thermogenesis
Retrograde endocannabinoid signaling
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Reactome:

Respiratory electron transport
Complex I biogenesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease name	Disease term	dbSNP ID	References
Mitochondrial diseases	Mitochondrial Diseases		15576045