NCAM2 (neural cell adhesion molecule 2)

Gene

• Entrez ID: 4685
• Gene name: Neural cell adhesion molecule 2
• Gene symbol: NCAM2
• Synonyms: NCAM21
• Chromosome: 21
• Chromosome location: 21q21.1
• Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018062	hsa-miR-335-5p	Microarray	18185580
MIRT029650	hsa-miR-26b-5p	Microarray	19088304
MIRT503840	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503839	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT503838	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503836	hsa-miR-3924	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT563183	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT563182	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT563181	hsa-miR-3653-3p	PAR-CLIP	20371350
MIRT563180	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT563179	hsa-miR-3658	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT527323	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527322	hsa-miR-5688	PAR-CLIP	22012620
MIRT527321	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT527320	hsa-miR-3065-5p	PAR-CLIP	22012620
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT444930	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT444929	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT444928	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444927	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT503840	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503839	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT503838	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503836	hsa-miR-3924	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT563183	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT563182	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT563181	hsa-miR-3653-3p	PAR-CLIP	20371350
MIRT563180	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT563179	hsa-miR-3658	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT527323	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527322	hsa-miR-5688	PAR-CLIP	22012620
MIRT527321	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT527320	hsa-miR-3065-5p	PAR-CLIP	22012620
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT444930	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT444929	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT444928	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444927	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT1175679	hsa-miR-1182	CLIP-seq
MIRT1175680	hsa-miR-1324	CLIP-seq
MIRT1175681	hsa-miR-133a	CLIP-seq
MIRT1175682	hsa-miR-133b	CLIP-seq
MIRT1175683	hsa-miR-203	CLIP-seq
MIRT1175684	hsa-miR-2278	CLIP-seq
MIRT1175685	hsa-miR-3120-3p	CLIP-seq
MIRT1175686	hsa-miR-3121-3p	CLIP-seq
MIRT1175687	hsa-miR-3130-3p	CLIP-seq
MIRT1175688	hsa-miR-340	CLIP-seq
MIRT1175689	hsa-miR-34b	CLIP-seq
MIRT1175690	hsa-miR-3616-5p	CLIP-seq
MIRT1175691	hsa-miR-3646	CLIP-seq
MIRT1175692	hsa-miR-3647-5p	CLIP-seq
MIRT1175693	hsa-miR-369-3p	CLIP-seq
MIRT1175694	hsa-miR-374a	CLIP-seq
MIRT1175695	hsa-miR-374b	CLIP-seq
MIRT1175696	hsa-miR-3974	CLIP-seq
MIRT1175697	hsa-miR-4264	CLIP-seq
MIRT1175698	hsa-miR-4421	CLIP-seq
MIRT1175699	hsa-miR-4422	CLIP-seq
MIRT1175700	hsa-miR-4517	CLIP-seq
MIRT1175701	hsa-miR-4635	CLIP-seq
MIRT1175702	hsa-miR-4662a-5p	CLIP-seq
MIRT1175703	hsa-miR-4704-3p	CLIP-seq
MIRT1175704	hsa-miR-4793-3p	CLIP-seq
MIRT1175705	hsa-miR-4797-3p	CLIP-seq
MIRT1175706	hsa-miR-4803	CLIP-seq
MIRT1175707	hsa-miR-515-5p	CLIP-seq
MIRT1175708	hsa-miR-545	CLIP-seq
MIRT1175709	hsa-miR-548p	CLIP-seq
MIRT1175710	hsa-miR-561	CLIP-seq
MIRT1175711	hsa-miR-573	CLIP-seq
MIRT1175712	hsa-miR-610	CLIP-seq
MIRT1175713	hsa-miR-668	CLIP-seq
MIRT2050850	hsa-miR-2116	CLIP-seq
MIRT2050851	hsa-miR-3613-3p	CLIP-seq
MIRT1175690	hsa-miR-3616-5p	CLIP-seq
MIRT1175692	hsa-miR-3647-5p	CLIP-seq
MIRT2050852	hsa-miR-3662	CLIP-seq
MIRT1175701	hsa-miR-4635	CLIP-seq
MIRT2050853	hsa-miR-4659a-3p	CLIP-seq
MIRT2050854	hsa-miR-4659b-3p	CLIP-seq
MIRT2050855	hsa-miR-548c-3p	CLIP-seq
MIRT1175710	hsa-miR-561	CLIP-seq
MIRT1175711	hsa-miR-573	CLIP-seq
MIRT2050856	hsa-miR-622	CLIP-seq
MIRT2279957	hsa-miR-1243	CLIP-seq
MIRT2279958	hsa-miR-1255a	CLIP-seq
MIRT2279959	hsa-miR-1255b	CLIP-seq
MIRT2279960	hsa-miR-127-5p	CLIP-seq
MIRT2279961	hsa-miR-197	CLIP-seq
MIRT1175685	hsa-miR-3120-3p	CLIP-seq
MIRT1175693	hsa-miR-369-3p	CLIP-seq
MIRT1175694	hsa-miR-374a	CLIP-seq
MIRT1175695	hsa-miR-374b	CLIP-seq
MIRT2279962	hsa-miR-383	CLIP-seq
MIRT1175698	hsa-miR-4421	CLIP-seq
MIRT1175699	hsa-miR-4422	CLIP-seq
MIRT2279963	hsa-miR-4699-3p	CLIP-seq
MIRT2279964	hsa-miR-4772-5p	CLIP-seq
MIRT2279965	hsa-miR-495	CLIP-seq
MIRT2279966	hsa-miR-5096	CLIP-seq
MIRT2279967	hsa-miR-520g	CLIP-seq
MIRT2279968	hsa-miR-520h	CLIP-seq
MIRT1175712	hsa-miR-610	CLIP-seq
MIRT1175713	hsa-miR-668	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IDA
GO:0007158	Process	Neuron cell-cell adhesion	TAS	9226371
GO:0007413	Process	Axonal fasciculation	IEA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0030424	Component	Axon	IEA
GO:0042802	Function	Identical protein binding	IPI	21300289
GO:0043005	Component	Neuron projection	IBA	21873635

Other IDs

• MIM: 602040
• HGNC: 7657
• e!Ensembl: ENSG00000154654

Protein

• UniProt ID: O15394
• Protein name: Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2)
• Protein function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
• PDB: 2DOC, 2JLL, 2KBG, 2V5T, 2VAJ, 2WIM, 2XY1, 2XY2, 2XYC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	21 → 111	Immunoglobulin I-set domain	Domain
  PF07679	I-set	115 → 198	Immunoglobulin I-set domain	Domain
  PF07679	I-set	211 → 298	Immunoglobulin I-set domain	Domain
  PF07679	I-set	302 → 397	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	401 → 479		Domain
  PF00041	fn3	497 → 581	Fibronectin type III domain	Domain
  PF00041	fn3	593 → 678	Fibronectin type III domain	Domain

• Sequence:

  MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK
  IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV
  VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD
  EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP
  AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
  QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH
  GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI
  SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH
  IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE
  IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
  GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM
  GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD
  VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT
  NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA

• Sequence length: 837

Pathways

KEGG:

Virion - Ebolavirus, Lyssavirus and Morbillivirus
Cell adhesion molecules
Prion disease

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077, rs587779206, rs63750439, rs63751405, rs63750741, rs63750854, rs63750909, rs587779212, rs63749874, rs267608076, rs587779220, rs63750735, rs267608082, rs587779227, rs267608068, rs63750075, rs587779232, rs267608058, rs63751127, rs63750138, rs267608065, rs63751017, rs587779246, rs63750111, rs63750563, rs267608073, rs63751407, rs63749999, rs267608042, rs63750833, rs587779255, rs587779256, rs267608078, rs267608092, rs587779263, rs267608098, rs587779267, rs63750194, rs63751327, rs63751328, rs587779284, rs63749942, rs63751058, rs267608114, rs267608118, rs63751319, rs267608128, rs1553333594, rs267608126, rs63750767, rs267608120, rs267608121, rs267608122, rs63750342, rs63749873, rs587779318, rs63750019, rs63749980, rs267608048, rs1553412283, rs146816935, rs63750855, rs63751711, rs267607789, rs587779094, rs63750224, rs267607972, rs63750084, rs587779185, rs587778617, rs398123231, rs398123232, rs398123318, rs587780021, rs63750119, rs267608064, rs587781490, rs587781558, rs587781691, rs63749821, rs587782111, rs587782326, rs587782704, rs587779264, rs587779333, rs587782712, rs587783056, rs730881825, rs730881827, rs730881829, rs730881830, rs786202193, rs587782281, rs786202848, rs786201049, rs750528093, rs786202108, rs267608083, rs786201050, rs786203924, rs587781544, rs786201084, rs1553333738, rs863224829, rs863225398, rs863225409, rs863225412, rs864622041, rs869312769, rs869312770, rs63751077, rs876661205, rs876661025, rs63749919, rs876661073, rs876661222, rs267608041, rs878853702, rs751326348, rs866260675, rs886039666, rs886044911, rs1057517552, rs1057517764, rs1057517763, rs121909224, rs1057520605, rs1060502885, rs1060502918, rs1060502932, rs587779215, rs1060502937, rs1060502886, rs1060502875, rs1060502881, rs267607939, rs1023534466, rs1064793600, rs1064795256, rs1064795591, rs1064794055, rs1064794164, rs1553414010, rs1064793671, rs1064794302, rs1064793489, rs1064794384, rs1064793781, rs1553333500, rs760190301, rs1114167719, rs1114167776, rs1114167704, rs1114167748, rs1114167731, rs753796271, rs267608055, rs1114167746, rs1114167715, rs587782706, rs1114167750, rs1114167765, rs1114167747, rs786204048, rs1114167707, rs1114167767, rs1114167717, rs1114167783, rs1553412966, rs1553333598, rs587779297, rs1554294505, rs988423880, rs1554306353, rs1553408136, rs1553333321, rs1553408388, rs63749973, rs1553412064, rs1553412120, rs1553826166, rs1553413784, rs1553331242, rs1553414519, rs1564568660, rs1558392033, rs878853704, rs765763906, rs1558663559, rs1572720704, rs63750985, rs1572727440, rs587779253, rs1580538168, rs149350323, rs374133543, rs771721952, rs201033017, rs763478027, rs1475633334, rs1580553624, rs1580553669, rs578113271, rs757194485, rs539295465, rs778610412, rs758191157, rs1580597397, rs1580033751, rs751236312, rs376667075, rs1561486630, rs1561486632, rs777054839, rs1204002507, rs766672143, rs1580091499, rs1386063673, rs1450314617, rs1580027713, rs367544716, rs1488467945, rs1580053768, rs1580553607, rs1572720794, rs1572722039, rs1572723786, rs1572725235, rs1572728112, rs1175196087, rs1572741984, rs1580540688, rs1259647122, rs1580546793, rs1234762807, rs1580556516, rs1669245178, rs1669365820, rs756190979, rs371356175, rs766997264, rs1743353294, rs1379605717, rs770330684, rs1462955256, rs1744356274, rs1480047980, rs1744149615	30093612
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	21552555

Unknown
Disease name	Disease term	dbSNP ID	References
Ovarian neoplasm	ovarian neoplasm		30898391