NCAM1 (neural cell adhesion molecule 1)

Gene

• Entrez ID: 4684
• Gene name: Neural cell adhesion molecule 1
• Gene symbol: NCAM1
• Synonyms: CD56, MSK39, NCAM
• Chromosome: 11
• Chromosome location: 11q23.2
• Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein pla

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003090	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT003159	hsa-miR-210-3p	immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR	19826008
MIRT006773	hsa-miR-200c-3p	Luciferase reporter assay	22707408
MIRT019976	hsa-miR-375	qRT-PCR;Microarray	20584986
MIRT003090	hsa-miR-122-5p	Microarray	17179747
MIRT003090	hsa-miR-122-5p	Microarray	17612493
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT731768	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26255203
MIRT1175644	hsa-miR-1284	CLIP-seq
MIRT1175645	hsa-miR-300	CLIP-seq
MIRT1175646	hsa-miR-381	CLIP-seq
MIRT1175647	hsa-miR-4323	CLIP-seq
MIRT1175648	hsa-miR-4329	CLIP-seq
MIRT1175649	hsa-miR-4663	CLIP-seq
MIRT1175650	hsa-miR-4666-3p	CLIP-seq
MIRT1175651	hsa-miR-4728-3p	CLIP-seq
MIRT1175652	hsa-miR-942	CLIP-seq
MIRT1175653	hsa-miR-204	CLIP-seq
MIRT1175654	hsa-miR-211	CLIP-seq
MIRT1175655	hsa-miR-3119	CLIP-seq
MIRT1175656	hsa-miR-3136-5p	CLIP-seq
MIRT1175657	hsa-miR-3163	CLIP-seq
MIRT1175658	hsa-miR-361-3p	CLIP-seq
MIRT1175659	hsa-miR-3614-5p	CLIP-seq
MIRT1175660	hsa-miR-3679-3p	CLIP-seq
MIRT1175661	hsa-miR-3686	CLIP-seq
MIRT1175662	hsa-miR-4286	CLIP-seq
MIRT1175648	hsa-miR-4329	CLIP-seq
MIRT1175663	hsa-miR-4439	CLIP-seq
MIRT1175664	hsa-miR-4446-5p	CLIP-seq
MIRT1175665	hsa-miR-4513	CLIP-seq
MIRT1175666	hsa-miR-4652-3p	CLIP-seq
MIRT1175649	hsa-miR-4663	CLIP-seq
MIRT1175667	hsa-miR-4713-5p	CLIP-seq
MIRT1175651	hsa-miR-4728-3p	CLIP-seq
MIRT1175668	hsa-miR-4742-3p	CLIP-seq
MIRT1175669	hsa-miR-4755-5p	CLIP-seq
MIRT1175670	hsa-miR-4766-5p	CLIP-seq
MIRT1175671	hsa-miR-548c-3p	CLIP-seq
MIRT1175672	hsa-miR-548g	CLIP-seq
MIRT1175673	hsa-miR-548l	CLIP-seq
MIRT1175674	hsa-miR-561	CLIP-seq
MIRT1175675	hsa-miR-623	CLIP-seq
MIRT1175676	hsa-miR-943	CLIP-seq
MIRT1175648	hsa-miR-4329	CLIP-seq
MIRT1175649	hsa-miR-4663	CLIP-seq
MIRT1175651	hsa-miR-4728-3p	CLIP-seq
MIRT1175677	hsa-miR-4731-3p	CLIP-seq
MIRT1175678	hsa-miR-4801	CLIP-seq
MIRT2050849	hsa-miR-4777-5p	CLIP-seq
MIRT1175653	hsa-miR-204	CLIP-seq
MIRT1175654	hsa-miR-211	CLIP-seq
MIRT1175644	hsa-miR-1284	CLIP-seq
MIRT1175645	hsa-miR-300	CLIP-seq
MIRT1175646	hsa-miR-381	CLIP-seq
MIRT1175647	hsa-miR-4323	CLIP-seq
MIRT1175650	hsa-miR-4666-3p	CLIP-seq
MIRT1175668	hsa-miR-4742-3p	CLIP-seq
MIRT1175652	hsa-miR-942	CLIP-seq
MIRT2431504	hsa-miR-3140-3p	CLIP-seq
MIRT2454900	hsa-miR-1285	CLIP-seq
MIRT2454901	hsa-miR-141	CLIP-seq
MIRT2454902	hsa-miR-200a	CLIP-seq
MIRT2454903	hsa-miR-30a	CLIP-seq
MIRT2454904	hsa-miR-30b	CLIP-seq
MIRT2454905	hsa-miR-30c	CLIP-seq
MIRT2454906	hsa-miR-30d	CLIP-seq
MIRT2454907	hsa-miR-30e	CLIP-seq
MIRT2454908	hsa-miR-3187-5p	CLIP-seq
MIRT2454909	hsa-miR-371b-5p	CLIP-seq
MIRT2454910	hsa-miR-378g	CLIP-seq
MIRT2454911	hsa-miR-4314	CLIP-seq
MIRT2454912	hsa-miR-4437	CLIP-seq
MIRT2454913	hsa-miR-4486	CLIP-seq
MIRT2454914	hsa-miR-4674	CLIP-seq
MIRT2454915	hsa-miR-4715-5p	CLIP-seq
MIRT2454916	hsa-miR-522	CLIP-seq
MIRT2454917	hsa-miR-570	CLIP-seq
MIRT2454918	hsa-miR-612	CLIP-seq
MIRT2454919	hsa-miR-875-3p	CLIP-seq
MIRT2578529	hsa-miR-1226	CLIP-seq
MIRT2578530	hsa-miR-4733-3p	CLIP-seq
MIRT2578531	hsa-miR-1271	CLIP-seq
MIRT2578532	hsa-miR-135a	CLIP-seq
MIRT2578533	hsa-miR-135b	CLIP-seq
MIRT2578534	hsa-miR-18a	CLIP-seq
MIRT2578535	hsa-miR-18b	CLIP-seq
MIRT2578536	hsa-miR-2681	CLIP-seq
MIRT2578537	hsa-miR-27a	CLIP-seq
MIRT2578538	hsa-miR-27b	CLIP-seq
MIRT2578539	hsa-miR-3117-5p	CLIP-seq
MIRT2578540	hsa-miR-3131	CLIP-seq
MIRT2578541	hsa-miR-3169	CLIP-seq
MIRT2578542	hsa-miR-328	CLIP-seq
MIRT2578543	hsa-miR-4735-3p	CLIP-seq
MIRT2578544	hsa-miR-4740-5p	CLIP-seq
MIRT1175670	hsa-miR-4766-5p	CLIP-seq
MIRT2578545	hsa-miR-513a-5p	CLIP-seq
MIRT2578546	hsa-miR-611	CLIP-seq
MIRT2578547	hsa-miR-96	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
IRF9	Activation	17431130
NFKB1	Activation	19091137
PAX2	Unknown	16406048;19485921
PAX8	Activation	8071351
RELA	Activation	19091137
RUNX1	Activation	16892559
SOX4	Activation	20049565

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0000165	Process	MAPK cascade	TAS
GO:0001618	Function	Virus receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007411	Process	Axon guidance	TAS
GO:0009897	Component	External side of plasma membrane	IDA	17213291
GO:0009986	Component	Cell surface	IDA	10766765
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0031225	Component	Anchored component of membrane	IEA
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0046718	Process	Viral entry into host cell	IEA
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27559042
GO:0071679	Process	Commissural neuron axon guidance	ISS
GO:2001260	Process	Regulation of semaphorin-plexin signaling pathway	ISS

Other IDs

• MIM: 116930
• HGNC: 7656
• e!Ensembl: ENSG00000149294

Protein

• UniProt ID: P13591
• Protein name: Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)
• Protein function: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; (Microbial infection) Acts as a receptor for rabies virus. ; (Micro
• PDB: 2E3V, 2HAZ, 2VKW, 2VKX, 3MTR, 5AEA, 5LKN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	20 → 114	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	119 → 192		Domain
  PF07679	I-set	214 → 304	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	307 → 399		Domain
  PF07679	I-set	418 → 505	Immunoglobulin I-set domain	Domain
  PF00041	fn3	508 → 598	Fibronectin type III domain	Domain
  PF00041	fn3	610 → 696	Fibronectin type III domain	Domain

• Sequence:

  MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
  KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
  KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
  KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
  PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
  HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE
  KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
  PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
  ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
  LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
  SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI
  RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS
  TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS
  KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE
  VKTVPNDATQTKENESKA

• Sequence length: 858

Pathways

KEGG:

Virion - Ebolavirus, Lyssavirus and Morbillivirus
Cell adhesion molecules
Prion disease

Reactome:

NCAM signaling for neurite out-growth
NCAM1 interactions
Signal transduction by L1
RAF/MAP kinase cascade
Interferon gamma signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Left ventricular hypertrophy	Left Ventricular Hypertrophy	rs397516037	21212386
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24057454, 25445624, 21515372, 31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder, Depression, Bipolar		17413444, 21515372, 24651862, 17239033, 15050861, 21939373
Mental depression	Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	14985425, 18973581, 17409734, 22361116, 18973581, 22361116, 17409734, 14985425, 18068248, 18068248, 29942085
Miscarriage	Miscarriage		18539642
Mood disorder	Mood Disorders		17409734, 29942085, 15050861