Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4670 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Heterogeneous nuclear ribonucleoprotein M |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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HNRNPM |
SynonymsGene synonyms aliases
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CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M |
ChromosomeChromosome number
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19 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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19p13.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000380 |
Process |
Alternative mRNA splicing, via spliceosome |
IBA |
21873635 |
GO:0000380 |
Process |
Alternative mRNA splicing, via spliceosome |
IMP |
19874820 |
GO:0000398 |
Process |
MRNA splicing, via spliceosome |
IC |
9731529, 11991638 |
GO:0000398 |
Process |
MRNA splicing, via spliceosome |
TAS |
|
GO:0003723 |
Function |
RNA binding |
HDA |
22658674, 22681889 |
GO:0003723 |
Function |
RNA binding |
NAS |
9731529 |
GO:0003729 |
Function |
MRNA binding |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
17435768, 18457437, 19874820, 20467437, 21988832, 24965446, 25416956, 25678563, 32296183 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
19874820 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005681 |
Component |
Spliceosomal complex |
IDA |
9731529 |
GO:0005730 |
Component |
Nucleolus |
IEA |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0008543 |
Process |
Fibroblast growth factor receptor signaling pathway |
TAS |
|
GO:0016020 |
Component |
Membrane |
HDA |
19946888 |
GO:0016070 |
Process |
RNA metabolic process |
TAS |
|
GO:0016363 |
Component |
Nuclear matrix |
IDA |
19874820 |
GO:0019904 |
Function |
Protein domain specific binding |
IPI |
11984006 |
GO:0042382 |
Component |
Paraspeckles |
IDA |
19874820 |
GO:0062023 |
Component |
Collagen-containing extracellular matrix |
HDA |
23658023 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
23533145 |
GO:0071013 |
Component |
Catalytic step 2 spliceosome |
IDA |
11991638 |
GO:0071014 |
Component |
Post-mRNA release spliceosomal complex |
IBA |
21873635 |
GO:1990904 |
Component |
Ribonucleoprotein complex |
IBA |
21873635 |
GO:2000815 |
Process |
Regulation of mRNA stability involved in response to oxidative stress |
IBA |
21873635 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P52272 |
Protein name |
Heterogeneous nuclear ribonucleoprotein M (hnRNP M) |
Protein function |
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
PDB |
2DGV
,
2DH9
,
2DO0
,
2OT8
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF11532 |
HnRNP_M |
41 → 70 |
Heterogeneous nuclear ribonucleoprotein M |
Family |
PF00076 |
RRM_1 |
73 → 143 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
PF00076 |
RRM_1 |
206 → 275 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
PF00076 |
RRM_1 |
655 → 723 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
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Sequence |
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Sequence length |
730 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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