HNRNPM (heterogeneous nuclear ribonucleoprotein M)

Gene

• Entrez ID: 4670
• Gene name: Heterogeneous nuclear ribonucleoprotein M
• Gene symbol: HNRNPM
• Synonyms: CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005120	hsa-miR-30a-5p	pSILAC	18668040
MIRT005120	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT029321	hsa-miR-26b-5p	Microarray	19088304
MIRT049986	hsa-miR-29a-3p	CLASH	23622248
MIRT049361	hsa-miR-92a-3p	CLASH	23622248
MIRT048765	hsa-miR-93-5p	CLASH	23622248
MIRT047057	hsa-miR-183-5p	CLASH	23622248
MIRT046439	hsa-miR-15b-5p	CLASH	23622248
MIRT045805	hsa-miR-191-5p	CLASH	23622248
MIRT043473	hsa-miR-331-3p	CLASH	23622248
MIRT042112	hsa-miR-484	CLASH	23622248
MIRT041425	hsa-miR-193b-3p	CLASH	23622248
MIRT040906	hsa-miR-18a-3p	CLASH	23622248
MIRT039993	hsa-miR-615-3p	CLASH	23622248
MIRT038991	hsa-let-7f-1-3p	CLASH	23622248
MIRT038991	hsa-let-7f-1-3p	CLASH	23622248
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT1051872	hsa-miR-1279	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051873	hsa-miR-3065-5p	CLIP-seq
MIRT1051874	hsa-miR-3914	CLIP-seq
MIRT1051875	hsa-miR-3973	CLIP-seq
MIRT1051876	hsa-miR-4680-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT1051877	hsa-miR-4789-5p	CLIP-seq
MIRT1051878	hsa-miR-4795-3p	CLIP-seq
MIRT1051879	hsa-miR-505	CLIP-seq
MIRT1051880	hsa-miR-520g	CLIP-seq
MIRT1051881	hsa-miR-520h	CLIP-seq
MIRT1051882	hsa-miR-873	CLIP-seq
MIRT1051872	hsa-miR-1279	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051873	hsa-miR-3065-5p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2244061	hsa-miR-3662	CLIP-seq
MIRT1051875	hsa-miR-3973	CLIP-seq
MIRT2244062	hsa-miR-4257	CLIP-seq
MIRT1051878	hsa-miR-4795-3p	CLIP-seq
MIRT1051879	hsa-miR-505	CLIP-seq
MIRT1051880	hsa-miR-520g	CLIP-seq
MIRT1051881	hsa-miR-520h	CLIP-seq
MIRT2244063	hsa-miR-522	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2547093	hsa-miR-3671	CLIP-seq
MIRT1051876	hsa-miR-4680-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT2547094	hsa-miR-4760-3p	CLIP-seq
MIRT1051877	hsa-miR-4789-5p	CLIP-seq
MIRT2547095	hsa-miR-548a-5p	CLIP-seq
MIRT2547096	hsa-miR-548ab	CLIP-seq
MIRT2547097	hsa-miR-548ak	CLIP-seq
MIRT2547098	hsa-miR-548b-5p	CLIP-seq
MIRT2547099	hsa-miR-548c-5p	CLIP-seq
MIRT2547100	hsa-miR-548d-5p	CLIP-seq
MIRT2547101	hsa-miR-548h	CLIP-seq
MIRT2547102	hsa-miR-548i	CLIP-seq
MIRT2547103	hsa-miR-548j	CLIP-seq
MIRT2547104	hsa-miR-548n	CLIP-seq
MIRT2547105	hsa-miR-548w	CLIP-seq
MIRT2547106	hsa-miR-548y	CLIP-seq
MIRT2547107	hsa-miR-559	CLIP-seq
MIRT2547108	hsa-miR-607	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2547093	hsa-miR-3671	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT2547094	hsa-miR-4760-3p	CLIP-seq
MIRT2547095	hsa-miR-548a-5p	CLIP-seq
MIRT2547096	hsa-miR-548ab	CLIP-seq
MIRT2547097	hsa-miR-548ak	CLIP-seq
MIRT2547098	hsa-miR-548b-5p	CLIP-seq
MIRT2547099	hsa-miR-548c-5p	CLIP-seq
MIRT2547100	hsa-miR-548d-5p	CLIP-seq
MIRT2547101	hsa-miR-548h	CLIP-seq
MIRT2547102	hsa-miR-548i	CLIP-seq
MIRT2547103	hsa-miR-548j	CLIP-seq
MIRT2547104	hsa-miR-548n	CLIP-seq
MIRT2547105	hsa-miR-548w	CLIP-seq
MIRT2547106	hsa-miR-548y	CLIP-seq
MIRT2547107	hsa-miR-559	CLIP-seq
MIRT2547108	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IBA	21873635
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IMP	19874820
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529, 11991638
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	NAS	9731529
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	17435768, 18457437, 19874820, 20467437, 21988832, 24965446, 25416956, 25678563, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA	19874820
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016070	Process	RNA metabolic process	TAS
GO:0016363	Component	Nuclear matrix	IDA	19874820
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0042382	Component	Paraspeckles	IDA	19874820
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	23658023
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0071014	Component	Post-mRNA release spliceosomal complex	IBA	21873635
GO:1990904	Component	Ribonucleoprotein complex	IBA	21873635
GO:2000815	Process	Regulation of mRNA stability involved in response to oxidative stress	IBA	21873635

Other IDs

• MIM: 160994
• HGNC: 5046
• e!Ensembl: ENSG00000099783

Protein

• UniProt ID: P52272
• Protein name: Heterogeneous nuclear ribonucleoprotein M (hnRNP M)
• Protein function: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosin
• PDB: 2DGV, 2DH9, 2DO0, 2OT8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11532	HnRNP_M	41 → 70	Heterogeneous nuclear ribonucleoprotein M	Family
  PF00076	RRM_1	73 → 143	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	206 → 275	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	655 → 723	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNR
  FEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFK
  MEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIP
  PSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKD
  GKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHG
  LGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENM
  GRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMG
  AGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIG
  SGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAG
  LERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPAL
  GAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNL
  PFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGR
  EIDVRIDRNA

• Sequence length: 730

Pathways

KEGG:

Spliceosome

Reactome:

FGFR2 alternative splicing
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778