NAB2 (NGFI-A binding protein 2)

Gene

• Entrez ID: 4665
• Gene name: NGFI-A binding protein 2
• Gene symbol: NAB2
• Synonyms: MADER
• Chromosome: 12
• Chromosome location: 12q13.3
• Summary: This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multim

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018637	hsa-miR-335-5p	Microarray	18185580
MIRT1172507	hsa-miR-1207-5p	CLIP-seq
MIRT1172508	hsa-miR-1275	CLIP-seq
MIRT1172509	hsa-miR-1280	CLIP-seq
MIRT1172510	hsa-miR-188-3p	CLIP-seq
MIRT1172511	hsa-miR-3179	CLIP-seq
MIRT1172512	hsa-miR-3668	CLIP-seq
MIRT1172513	hsa-miR-4436b-3p	CLIP-seq
MIRT1172514	hsa-miR-4640-5p	CLIP-seq
MIRT1172515	hsa-miR-4650-5p	CLIP-seq
MIRT1172516	hsa-miR-4665-5p	CLIP-seq
MIRT1172517	hsa-miR-4713-3p	CLIP-seq
MIRT1172518	hsa-miR-4726-5p	CLIP-seq
MIRT1172519	hsa-miR-4740-3p	CLIP-seq
MIRT1172520	hsa-miR-4761-3p	CLIP-seq
MIRT1172521	hsa-miR-4763-3p	CLIP-seq
MIRT1172522	hsa-miR-495	CLIP-seq
MIRT1172523	hsa-miR-518a-5p	CLIP-seq
MIRT1172524	hsa-miR-527	CLIP-seq
MIRT2049852	hsa-miR-134	CLIP-seq
MIRT2049853	hsa-miR-1915	CLIP-seq
MIRT2049854	hsa-miR-2467-3p	CLIP-seq
MIRT2049855	hsa-miR-28-3p	CLIP-seq
MIRT2049856	hsa-miR-296-3p	CLIP-seq
MIRT2049857	hsa-miR-3064-3p	CLIP-seq
MIRT2049858	hsa-miR-3118	CLIP-seq
MIRT2049859	hsa-miR-3125	CLIP-seq
MIRT2049860	hsa-miR-3164	CLIP-seq
MIRT2049861	hsa-miR-3916	CLIP-seq
MIRT2049862	hsa-miR-409-3p	CLIP-seq
MIRT2049863	hsa-miR-4252	CLIP-seq
MIRT2049864	hsa-miR-4423-5p	CLIP-seq
MIRT1172513	hsa-miR-4436b-3p	CLIP-seq
MIRT2049865	hsa-miR-4476	CLIP-seq
MIRT2049866	hsa-miR-4535	CLIP-seq
MIRT2049867	hsa-miR-4661-3p	CLIP-seq
MIRT2049868	hsa-miR-4685-5p	CLIP-seq
MIRT2049869	hsa-miR-4715-3p	CLIP-seq
MIRT2049870	hsa-miR-492	CLIP-seq
MIRT2049871	hsa-miR-758	CLIP-seq
MIRT2049872	hsa-miR-767-3p	CLIP-seq
MIRT2049852	hsa-miR-134	CLIP-seq
MIRT2049854	hsa-miR-2467-3p	CLIP-seq
MIRT2049856	hsa-miR-296-3p	CLIP-seq
MIRT2049858	hsa-miR-3118	CLIP-seq
MIRT2049859	hsa-miR-3125	CLIP-seq
MIRT2049860	hsa-miR-3164	CLIP-seq
MIRT2049861	hsa-miR-3916	CLIP-seq
MIRT2049865	hsa-miR-4476	CLIP-seq
MIRT2049867	hsa-miR-4661-3p	CLIP-seq
MIRT2049868	hsa-miR-4685-5p	CLIP-seq
MIRT2049871	hsa-miR-758	CLIP-seq
MIRT1172515	hsa-miR-4650-5p	CLIP-seq
MIRT1172519	hsa-miR-4740-3p	CLIP-seq
MIRT2577121	hsa-miR-122	CLIP-seq
MIRT2577122	hsa-miR-1228	CLIP-seq
MIRT2577123	hsa-miR-1276	CLIP-seq
MIRT2577124	hsa-miR-1294	CLIP-seq
MIRT2577125	hsa-miR-1321	CLIP-seq
MIRT2577126	hsa-miR-146b-3p	CLIP-seq
MIRT2577127	hsa-miR-147	CLIP-seq
MIRT2577128	hsa-miR-1827	CLIP-seq
MIRT2577129	hsa-miR-19a	CLIP-seq
MIRT2577130	hsa-miR-19b	CLIP-seq
MIRT2577131	hsa-miR-3123	CLIP-seq
MIRT2577132	hsa-miR-3126-5p	CLIP-seq
MIRT2577133	hsa-miR-3173-5p	CLIP-seq
MIRT2577134	hsa-miR-3612	CLIP-seq
MIRT2577135	hsa-miR-4254	CLIP-seq
MIRT2577136	hsa-miR-4308	CLIP-seq
MIRT2577137	hsa-miR-4311	CLIP-seq
MIRT2577138	hsa-miR-4313	CLIP-seq
MIRT2577139	hsa-miR-4316	CLIP-seq
MIRT2577140	hsa-miR-4419a	CLIP-seq
MIRT2577141	hsa-miR-4443	CLIP-seq
MIRT2577142	hsa-miR-4510	CLIP-seq
MIRT2577143	hsa-miR-4668-5p	CLIP-seq
MIRT2577144	hsa-miR-4728-5p	CLIP-seq
MIRT2577145	hsa-miR-4739	CLIP-seq
MIRT2577146	hsa-miR-4744	CLIP-seq
MIRT2577147	hsa-miR-4756-5p	CLIP-seq
MIRT2577148	hsa-miR-502-5p	CLIP-seq
MIRT2577149	hsa-miR-548q	CLIP-seq
MIRT2577150	hsa-miR-574-5p	CLIP-seq
MIRT2577151	hsa-miR-583	CLIP-seq
MIRT2577152	hsa-miR-650	CLIP-seq
MIRT2577153	hsa-miR-874	CLIP-seq
MIRT2577121	hsa-miR-122	CLIP-seq
MIRT2577122	hsa-miR-1228	CLIP-seq
MIRT2577123	hsa-miR-1276	CLIP-seq
MIRT2577124	hsa-miR-1294	CLIP-seq
MIRT2577125	hsa-miR-1321	CLIP-seq
MIRT2577126	hsa-miR-146b-3p	CLIP-seq
MIRT2577127	hsa-miR-147	CLIP-seq
MIRT2577128	hsa-miR-1827	CLIP-seq
MIRT2577129	hsa-miR-19a	CLIP-seq
MIRT2577130	hsa-miR-19b	CLIP-seq
MIRT2577131	hsa-miR-3123	CLIP-seq
MIRT2577132	hsa-miR-3126-5p	CLIP-seq
MIRT2577133	hsa-miR-3173-5p	CLIP-seq
MIRT2577134	hsa-miR-3612	CLIP-seq
MIRT2577135	hsa-miR-4254	CLIP-seq
MIRT2577136	hsa-miR-4308	CLIP-seq
MIRT2577137	hsa-miR-4311	CLIP-seq
MIRT2577139	hsa-miR-4316	CLIP-seq
MIRT2577140	hsa-miR-4419a	CLIP-seq
MIRT2577141	hsa-miR-4443	CLIP-seq
MIRT2577142	hsa-miR-4510	CLIP-seq
MIRT2577143	hsa-miR-4668-5p	CLIP-seq
MIRT2577144	hsa-miR-4728-5p	CLIP-seq
MIRT2577145	hsa-miR-4739	CLIP-seq
MIRT2577146	hsa-miR-4744	CLIP-seq
MIRT2577147	hsa-miR-4756-5p	CLIP-seq
MIRT2577149	hsa-miR-548q	CLIP-seq
MIRT2577150	hsa-miR-574-5p	CLIP-seq
MIRT2577151	hsa-miR-583	CLIP-seq
MIRT2577152	hsa-miR-650	CLIP-seq
MIRT2577153	hsa-miR-874	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
EGR1	Activation	16260776;20506119
EGR3	Activation	20506119

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001958	Process	Endochondral ossification	IEA
GO:0003712	Function	Transcription coregulator activity	IBA	21873635
GO:0003714	Function	Transcription corepressor activity	TAS	8668170
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 29892012, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0008134	Function	Transcription factor binding	IBA	21873635
GO:0014037	Process	Schwann cell differentiation	IEA
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IDA	8668170
GO:0042552	Process	Myelination	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0045682	Process	Regulation of epidermis development	IEA
GO:1902949	Process	Positive regulation of tau-protein kinase activity	ISS

Other IDs

• MIM: 602381
• HGNC: 7627
• e!Ensembl: ENSG00000166886

Protein

• UniProt ID: Q15742
• Protein name: NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER)
• Protein function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04904	NCD1	36 → 114	NAB conserved region 1 (NCD1)	Domain
  PF04905	NCD2	236 → 364	NAB conserved region 2 (NCD2)	Family

• Sequence:

  MHRAPSPTAEQPPGGGDSARRTLQPRLKPSARAMALPRTLGELQLYRVLQRANLLSYYET
  FIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFSQPVPAV
  PVSSIPLFKISETAGTRKGSMSNGHGSPGEKAGSARSFSPKSPLELGEKLSPLPGGPGAG
  DPRIWPGRSTPESDVGAGGEEEAGSPPFSPPAGGGVPEGTGAGGLAAGGTGGGPDRLEPE
  MVRMVVESVERIFRSFPRGDAGEVTSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSI
  IYGRFDSKRREGKQLSLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSL
  KGSRLHPEELGGPPLKKLKQEVGEQSHPEIQQPPPGPESYVPPYRPSLEEDSASLSGESL
  DGHLQAVGSCPRLTPPPADLPLALPAHGLWSRHILQQTLMDEGLRLARLVSHDRVGRLSP
  CVPAKPPLAEFEEGLLDRCPAPGPHPALVEGRRSSVKVEAEASRQ

• Sequence length: 525

Pathways

Reactome:

NGF-stimulated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypophosphatemic rickets	Hypophosphatemic Rickets	rs104894347, rs28937882, rs587776696, rs587776697, rs587776698, rs121908248, rs587776797, rs121908249, rs193922701, rs193922702, rs886041227, rs886041363, rs886041296, rs886041369, rs866429868, rs1556025994, rs1064793847, rs1556128253, rs1554278331, rs899142959, rs373044722
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrial neoplasms	Uterine Neoplasms
Hemangiopericytoma	hemangiopericytoma		23313952, 23313954
Solitary fibrous tumor	Solitary fibrous tumor		23313954, 23313952
Hypoinsulinemia	Hypoinsulinaemia (disorder)
Liver neoplasms	Liver neoplasms
Lung neoplasms	Lung Neoplasms
Soft tissue neoplasms	Soft Tissue Neoplasms
Neoplasia of the pleura	Neoplasia of the pleura
Nervous system neoplasms	Nervous System Neoplasms
Vaginal neoplasms	Vaginal Neoplasms