MYCL (MYCL proto-oncogene, bHLH transcription factor)

Gene

• Entrez ID: 4610
• Gene name: MYCL proto-oncogene, bHLH transcription factor
• Gene symbol: MYCL
• Synonyms: L-Myc, LMYC, MYCL1, bHLHe38
• Chromosome: 1
• Chromosome location: 1p34.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT640804	hsa-miR-4506	HITS-CLIP	23824327
MIRT640803	hsa-miR-4328	HITS-CLIP	23824327
MIRT640802	hsa-miR-569	HITS-CLIP	23824327
MIRT640801	hsa-miR-2053	HITS-CLIP	23824327
MIRT439153	hsa-let-7c-5p	3'LIFE	25074381
MIRT439153	hsa-let-7c-5p	3'LIFE	25074381
MIRT742255	hsa-miR-4506	HITS-CLIP	23824327
MIRT742256	hsa-miR-4328	HITS-CLIP	23824327
MIRT742257	hsa-miR-569	HITS-CLIP	23824327
MIRT742258	hsa-miR-2053	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	NAS	3322939
GO:0003677	Function	DNA binding	TAS	10597290
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045607	Process	Regulation of inner ear auditory receptor cell differentiation	IEA
GO:0046983	Function	Protein dimerization activity	IEA

Other IDs

• MIM: 164850
• HGNC: 7555
• e!Ensembl: ENSG00000116990

Protein

• UniProt ID: P12524
• Protein name: Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01056	Myc_N	1 → 161	Myc amino-terminal region	Family
  PF01056	Myc_N	143 → 237	Myc amino-terminal region	Family
  PF00010	HLH	282 → 334	Helix-loop-helix DNA-binding domain	Domain

• Sequence:

  MDYDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPPWGLGPGAGDPAPGIGP
  PEPWPGGCTGDEAESRGHSKGWGRNYASIIRRDCMWSGFSARERLERAVSDRLAPGAPRG
  NPPKASAAPDCTPSLEAGNPAPAAPCPLGEPKTQACSGSESPSDSENEEIDVVTVEKRQS
  LGIRKPVTITVRADPLDPCMKHFHISIHQQQHNYAARFPPESCSQEEASERGPQEEVLER
  DAAGEKEDEEDEEIVSPPPVESEAAQSCHPKPVSSDTEDVTKRKNHNFLERKRRNDLRSR
  FLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMATEKRQLRCRQQQLQKRIAY
  LTGY

• Sequence length: 364

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22941189
Medulloblastoma	Medulloblastoma, Childhood Medulloblastoma, Adult Medulloblastoma, Desmoplastic Medulloblastoma, Melanotic medulloblastoma	rs1589970134, rs587776578, rs587776579, rs17847577, rs111033171, rs80359604, rs80358785, rs80358814, rs863224925, rs1555950011, rs1554231278, rs926177767, rs759412460, rs1564032829, rs761911009	19270706
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	26005866

Unknown
Disease name	Disease term	dbSNP ID	References
Medullomyoblastoma	Medullomyoblastoma		19270706
Prostatic neoplasms	Prostatic Neoplasms		26005866