MYBL2 (MYB proto-oncogene like 2)

Gene

• Entrez ID: 4605
• Gene name: MYB proto-oncogene like 2
• Gene symbol: MYBL2
• Synonyms: B-MYB, BMYB
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006045	hsa-miR-30e-5p	Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot	21187425
MIRT006045	hsa-miR-30e-5p	Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot	21187425
MIRT006045	hsa-miR-30e-5p	Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot	21187425
MIRT021213	hsa-miR-149-3p	Reporter assay;Western blot;qRT-PCR	20623644
MIRT049701	hsa-miR-92a-3p	CLASH	23622248
MIRT041019	hsa-miR-505-3p	CLASH	23622248
MIRT038033	hsa-miR-423-5p	CLASH	23622248
MIRT437542	hsa-miR-19b-3p	Immunoprecipitaion	22382630
MIRT727125	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT727124	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT727123	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT727122	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT006045	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT021213	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT038033	hsa-miR-423-5p	PAR-CLIP	27292025
MIRT736221	hsa-miR-29b-2-5p	RNA-seq, qRT-PCR	33808771
MIRT1167644	hsa-miR-1205	CLIP-seq
MIRT1167645	hsa-miR-1207-3p	CLIP-seq
MIRT1167646	hsa-miR-1286	CLIP-seq
MIRT1167647	hsa-miR-1291	CLIP-seq
MIRT1167648	hsa-miR-138	CLIP-seq
MIRT1167649	hsa-miR-146b-3p	CLIP-seq
MIRT1167650	hsa-miR-29a	CLIP-seq
MIRT1167651	hsa-miR-29b	CLIP-seq
MIRT1167652	hsa-miR-29c	CLIP-seq
MIRT1167653	hsa-miR-30a	CLIP-seq
MIRT1167654	hsa-miR-30b	CLIP-seq
MIRT1167655	hsa-miR-30c	CLIP-seq
MIRT1167656	hsa-miR-30d	CLIP-seq
MIRT1167657	hsa-miR-30e	CLIP-seq
MIRT1167658	hsa-miR-3152-5p	CLIP-seq
MIRT1167659	hsa-miR-3184	CLIP-seq
MIRT1167660	hsa-miR-328	CLIP-seq
MIRT1167661	hsa-miR-3607-3p	CLIP-seq
MIRT1167662	hsa-miR-3613-3p	CLIP-seq
MIRT1167663	hsa-miR-3663-3p	CLIP-seq
MIRT1167664	hsa-miR-378g	CLIP-seq
MIRT1167665	hsa-miR-4423-5p	CLIP-seq
MIRT1167666	hsa-miR-4436b-3p	CLIP-seq
MIRT1167667	hsa-miR-4437	CLIP-seq
MIRT1167668	hsa-miR-4632	CLIP-seq
MIRT1167669	hsa-miR-4674	CLIP-seq
MIRT1167670	hsa-miR-4717-3p	CLIP-seq
MIRT1167671	hsa-miR-4722-5p	CLIP-seq
MIRT1167672	hsa-miR-4733-3p	CLIP-seq
MIRT1167673	hsa-miR-4792	CLIP-seq
MIRT1167674	hsa-miR-501-3p	CLIP-seq
MIRT1167675	hsa-miR-502-3p	CLIP-seq
MIRT1167676	hsa-miR-580	CLIP-seq
MIRT1167677	hsa-miR-590-3p	CLIP-seq
MIRT1167678	hsa-miR-665	CLIP-seq
MIRT1167679	hsa-miR-767-5p	CLIP-seq
MIRT1167680	hsa-miR-939	CLIP-seq
MIRT2048361	hsa-miR-1182	CLIP-seq
MIRT2048362	hsa-miR-1273f	CLIP-seq
MIRT2048363	hsa-miR-143	CLIP-seq
MIRT2048364	hsa-miR-1913	CLIP-seq
MIRT2048365	hsa-miR-27a	CLIP-seq
MIRT2048366	hsa-miR-27b	CLIP-seq
MIRT1167650	hsa-miR-29a	CLIP-seq
MIRT1167651	hsa-miR-29b	CLIP-seq
MIRT1167652	hsa-miR-29c	CLIP-seq
MIRT1167653	hsa-miR-30a	CLIP-seq
MIRT1167654	hsa-miR-30b	CLIP-seq
MIRT1167655	hsa-miR-30c	CLIP-seq
MIRT1167656	hsa-miR-30d	CLIP-seq
MIRT1167657	hsa-miR-30e	CLIP-seq
MIRT2048367	hsa-miR-324-3p	CLIP-seq
MIRT2048368	hsa-miR-331-3p	CLIP-seq
MIRT1167661	hsa-miR-3607-3p	CLIP-seq
MIRT2048369	hsa-miR-361-3p	CLIP-seq
MIRT2048370	hsa-miR-3661	CLIP-seq
MIRT1167663	hsa-miR-3663-3p	CLIP-seq
MIRT2048371	hsa-miR-4251	CLIP-seq
MIRT2048372	hsa-miR-4313	CLIP-seq
MIRT2048373	hsa-miR-4329	CLIP-seq
MIRT2048374	hsa-miR-4330	CLIP-seq
MIRT1167667	hsa-miR-4437	CLIP-seq
MIRT2048375	hsa-miR-4514	CLIP-seq
MIRT1167668	hsa-miR-4632	CLIP-seq
MIRT2048376	hsa-miR-4640-3p	CLIP-seq
MIRT2048377	hsa-miR-4645-5p	CLIP-seq
MIRT2048378	hsa-miR-4650-5p	CLIP-seq
MIRT2048379	hsa-miR-4673	CLIP-seq
MIRT1167669	hsa-miR-4674	CLIP-seq
MIRT2048380	hsa-miR-4692	CLIP-seq
MIRT2048381	hsa-miR-4701-5p	CLIP-seq
MIRT2048382	hsa-miR-4708-5p	CLIP-seq
MIRT1167672	hsa-miR-4733-3p	CLIP-seq
MIRT2048383	hsa-miR-4755-3p	CLIP-seq
MIRT2048384	hsa-miR-4770	CLIP-seq
MIRT1167673	hsa-miR-4792	CLIP-seq
MIRT2048385	hsa-miR-4795-5p	CLIP-seq
MIRT2048386	hsa-miR-513a-5p	CLIP-seq
MIRT1167676	hsa-miR-580	CLIP-seq
MIRT2048387	hsa-miR-588	CLIP-seq
MIRT2048388	hsa-miR-619	CLIP-seq
MIRT2048389	hsa-miR-631	CLIP-seq
MIRT1167678	hsa-miR-665	CLIP-seq
MIRT1167680	hsa-miR-939	CLIP-seq
MIRT2048364	hsa-miR-1913	CLIP-seq
MIRT2048365	hsa-miR-27a	CLIP-seq
MIRT2048366	hsa-miR-27b	CLIP-seq
MIRT1167653	hsa-miR-30a	CLIP-seq
MIRT1167654	hsa-miR-30b	CLIP-seq
MIRT1167655	hsa-miR-30c	CLIP-seq
MIRT1167656	hsa-miR-30d	CLIP-seq
MIRT1167657	hsa-miR-30e	CLIP-seq
MIRT2048367	hsa-miR-324-3p	CLIP-seq
MIRT1167661	hsa-miR-3607-3p	CLIP-seq
MIRT2048372	hsa-miR-4313	CLIP-seq
MIRT2048374	hsa-miR-4330	CLIP-seq
MIRT2048376	hsa-miR-4640-3p	CLIP-seq
MIRT2048386	hsa-miR-513a-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Activation	14618416;16299810
MYBL2	Unknown	15922873
MYCN	Activation	21304178
SP1	Unknown	15922873
TFDP1	Activation	14618416

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10770937
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	10770937
GO:0005515	Function	Protein binding	IPI	17159899, 17531812, 19725879
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS
GO:0031523	Component	Myb complex	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10770937
GO:0051726	Process	Regulation of cell cycle	TAS
GO:0090307	Process	Mitotic spindle assembly	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 601415
• HGNC: 7548
• e!Ensembl: ENSG00000101057

Protein

• UniProt ID: P10244
• Protein name: Myb-related protein B (B-Myb) (Myb-like protein 2)
• Protein function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
• PDB: 6C48
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13921	Myb_DNA-bind_6	34 → 94		Domain
  PF00249	Myb_DNA-binding	135 → 180	Myb-like DNA-binding domain	Domain
  PF09316	Cmyb_C	451 → 607	C-myb, C-terminal	Family

• Sequence:

  MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASH
  FPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQ
  CRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTI
  KRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEEN
  SEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLL
  IPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQ
  PSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVAL
  SPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCS
  QKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPH
  LEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMS
  TLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMS
  SAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS

• Sequence length: 700

Pathways

KEGG:

Cellular senescence

Reactome:

Polo-like kinase mediated events
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560