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MYB (MYB proto-oncogene, transcription factor)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4602
Gene nameGene Name - the full gene name approved by the HGNC.
MYB proto-oncogene, transcription factor
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MYB
SynonymsGene synonyms aliases
Cmyb, c-myb, c-myb_CDS, efg
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocati
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Luciferase reporter assay 18667440
Transcription factors
Transcription factor Regulation Reference
BCL3 Unknown 9694711
E2F1 Unknown 8137237
EGR1 Repression 7559553
ETS1 Activation 7848925
FOSL2 Activation 22493372
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 20531406
GO:0000278 Process Mitotic cell cycle IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 7987850
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P10242
Protein name Transcriptional activator Myb (Proto-oncogene c-Myb)
Protein function Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00249 Myb_DNA-binding
92 138
Myb-like DNA-binding domain
Domain
PF00249 Myb_DNA-binding
144 189
Myb-like DNA-binding domain
Domain
PF07988 LMSTEN
267 313
LMSTEN motif
Motif
PF09316 Cmyb_C
399 563
C-myb, C-terminal
Family
Sequence
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHL
NPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTM
RRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV
NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL
LLMSTENELKGQQ
VLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD
PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT
STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK
YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNF
FCSHHWEGDSLNTQLFTQTSPVA
DAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP
LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
Sequence length 640
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  PI3K-Akt signaling pathway   RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Adenocarcinoma Adenoid Cystic Carcinoma rs121913530, rs886039394, rs121913474 23685749, 26829750
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 19198610
Glioma Glioma, mixed gliomas, Malignant Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701 23583981, 26829751, 26829751, 23583981
Lymphoblastic leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-cell acute lymphoblastic leukemia rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591 28671688, 17435759
Unknown
Disease name Disease term dbSNP ID References
Angiocentric glioma Angiocentric glioma 26829751
Basophilic leukemia Acute Basophilic Leukemia 21474671

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