MUC6 (mucin 6, oligomeric mucus/gel-forming (gene/pseudogene))

Gene

• Entrez ID: 4588
• Gene name: Mucin 6, oligomeric mucus/gel-forming (gene/pseudogene)
• Gene symbol: MUC6
• Synonyms: MUC-6
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018331	hsa-miR-335-5p	Microarray	18185580
MIRT1166376	hsa-miR-125a-5p	CLIP-seq
MIRT1166377	hsa-miR-125b	CLIP-seq
MIRT1166378	hsa-miR-1285	CLIP-seq
MIRT1166379	hsa-miR-1913	CLIP-seq
MIRT1166380	hsa-miR-214	CLIP-seq
MIRT1166381	hsa-miR-296-5p	CLIP-seq
MIRT1166382	hsa-miR-3187-5p	CLIP-seq
MIRT1166383	hsa-miR-324-3p	CLIP-seq
MIRT1166384	hsa-miR-326	CLIP-seq
MIRT1166385	hsa-miR-330-5p	CLIP-seq
MIRT1166386	hsa-miR-345	CLIP-seq
MIRT1166387	hsa-miR-3619-5p	CLIP-seq
MIRT1166388	hsa-miR-378g	CLIP-seq
MIRT1166389	hsa-miR-4290	CLIP-seq
MIRT1166390	hsa-miR-4314	CLIP-seq
MIRT1166391	hsa-miR-4319	CLIP-seq
MIRT1166392	hsa-miR-4438	CLIP-seq
MIRT1166393	hsa-miR-4446-3p	CLIP-seq
MIRT1166394	hsa-miR-4450	CLIP-seq
MIRT1166395	hsa-miR-4455	CLIP-seq
MIRT1166396	hsa-miR-4486	CLIP-seq
MIRT1166397	hsa-miR-4492	CLIP-seq
MIRT1166398	hsa-miR-4498	CLIP-seq
MIRT1166399	hsa-miR-4505	CLIP-seq
MIRT1166400	hsa-miR-4522	CLIP-seq
MIRT1166401	hsa-miR-4530	CLIP-seq
MIRT1166402	hsa-miR-4667-5p	CLIP-seq
MIRT1166403	hsa-miR-4700-5p	CLIP-seq
MIRT1166404	hsa-miR-4731-5p	CLIP-seq
MIRT1166405	hsa-miR-4732-3p	CLIP-seq
MIRT1166406	hsa-miR-609	CLIP-seq
MIRT1166407	hsa-miR-612	CLIP-seq
MIRT1166408	hsa-miR-670	CLIP-seq
MIRT1166409	hsa-miR-761	CLIP-seq
MIRT1166410	hsa-miR-762	CLIP-seq
MIRT1166389	hsa-miR-4290	CLIP-seq
MIRT2276800	hsa-miR-1184	CLIP-seq
MIRT2276801	hsa-miR-1205	CLIP-seq
MIRT2276802	hsa-miR-1207-5p	CLIP-seq
MIRT2276803	hsa-miR-1237	CLIP-seq
MIRT2276804	hsa-miR-1254	CLIP-seq
MIRT2276805	hsa-miR-1293	CLIP-seq
MIRT2276806	hsa-miR-138	CLIP-seq
MIRT2276807	hsa-miR-146b-3p	CLIP-seq
MIRT2276808	hsa-miR-150	CLIP-seq
MIRT2276809	hsa-miR-184	CLIP-seq
MIRT2276810	hsa-miR-1909	CLIP-seq
MIRT2276811	hsa-miR-1910	CLIP-seq
MIRT2276812	hsa-miR-205	CLIP-seq
MIRT2276813	hsa-miR-2278	CLIP-seq
MIRT2276814	hsa-miR-3074-5p	CLIP-seq
MIRT2276815	hsa-miR-3116	CLIP-seq
MIRT2276816	hsa-miR-3120-5p	CLIP-seq
MIRT2276817	hsa-miR-3157-5p	CLIP-seq
MIRT2276818	hsa-miR-3158-5p	CLIP-seq
MIRT2276819	hsa-miR-3173-5p	CLIP-seq
MIRT2276820	hsa-miR-3179	CLIP-seq
MIRT2276821	hsa-miR-3192	CLIP-seq
MIRT2276822	hsa-miR-3202	CLIP-seq
MIRT2276823	hsa-miR-323-5p	CLIP-seq
MIRT2276824	hsa-miR-3689a-3p	CLIP-seq
MIRT2276825	hsa-miR-3689c	CLIP-seq
MIRT2276826	hsa-miR-371b-3p	CLIP-seq
MIRT2276827	hsa-miR-3907	CLIP-seq
MIRT2276828	hsa-miR-4323	CLIP-seq
MIRT2276829	hsa-miR-4421	CLIP-seq
MIRT1166392	hsa-miR-4438	CLIP-seq
MIRT2276830	hsa-miR-4447	CLIP-seq
MIRT1166394	hsa-miR-4450	CLIP-seq
MIRT1166395	hsa-miR-4455	CLIP-seq
MIRT2276831	hsa-miR-4456	CLIP-seq
MIRT2276832	hsa-miR-4472	CLIP-seq
MIRT2276833	hsa-miR-4483	CLIP-seq
MIRT2276834	hsa-miR-4488	CLIP-seq
MIRT1166397	hsa-miR-4492	CLIP-seq
MIRT1166398	hsa-miR-4498	CLIP-seq
MIRT1166399	hsa-miR-4505	CLIP-seq
MIRT2276835	hsa-miR-4514	CLIP-seq
MIRT2276836	hsa-miR-4536	CLIP-seq
MIRT2276837	hsa-miR-4651	CLIP-seq
MIRT1166402	hsa-miR-4667-5p	CLIP-seq
MIRT2276838	hsa-miR-4670-5p	CLIP-seq
MIRT2276839	hsa-miR-4690-3p	CLIP-seq
MIRT2276840	hsa-miR-4690-5p	CLIP-seq
MIRT2276841	hsa-miR-4692	CLIP-seq
MIRT2276842	hsa-miR-4697-5p	CLIP-seq
MIRT1166403	hsa-miR-4700-5p	CLIP-seq
MIRT2276843	hsa-miR-4713-5p	CLIP-seq
MIRT2276844	hsa-miR-4725-5p	CLIP-seq
MIRT2276845	hsa-miR-4727-5p	CLIP-seq
MIRT2276846	hsa-miR-4728-5p	CLIP-seq
MIRT1166404	hsa-miR-4731-5p	CLIP-seq
MIRT2276847	hsa-miR-4747-5p	CLIP-seq
MIRT2276848	hsa-miR-4763-3p	CLIP-seq
MIRT2276849	hsa-miR-4768-3p	CLIP-seq
MIRT2276850	hsa-miR-4804-5p	CLIP-seq
MIRT2276851	hsa-miR-504	CLIP-seq
MIRT2276852	hsa-miR-532-3p	CLIP-seq
MIRT2276853	hsa-miR-541	CLIP-seq
MIRT2276854	hsa-miR-550a	CLIP-seq
MIRT2276855	hsa-miR-608	CLIP-seq
MIRT1166406	hsa-miR-609	CLIP-seq
MIRT2276856	hsa-miR-654-5p	CLIP-seq
MIRT2276857	hsa-miR-661	CLIP-seq
MIRT2276858	hsa-miR-665	CLIP-seq
MIRT1166410	hsa-miR-762	CLIP-seq
MIRT2276859	hsa-miR-874	CLIP-seq
MIRT2276860	hsa-miR-885-3p	CLIP-seq
MIRT2276812	hsa-miR-205	CLIP-seq
MIRT2276813	hsa-miR-2278	CLIP-seq
MIRT2276817	hsa-miR-3157-5p	CLIP-seq
MIRT2276828	hsa-miR-4323	CLIP-seq
MIRT2276835	hsa-miR-4514	CLIP-seq
MIRT2276839	hsa-miR-4690-3p	CLIP-seq
MIRT2276840	hsa-miR-4690-5p	CLIP-seq
MIRT2276841	hsa-miR-4692	CLIP-seq
MIRT2276849	hsa-miR-4768-3p	CLIP-seq
MIRT2276858	hsa-miR-665	CLIP-seq
MIRT2276812	hsa-miR-205	CLIP-seq
MIRT2276813	hsa-miR-2278	CLIP-seq
MIRT2276817	hsa-miR-3157-5p	CLIP-seq
MIRT2276828	hsa-miR-4323	CLIP-seq
MIRT2276835	hsa-miR-4514	CLIP-seq
MIRT2276839	hsa-miR-4690-3p	CLIP-seq
MIRT2276840	hsa-miR-4690-5p	CLIP-seq
MIRT2276841	hsa-miR-4692	CLIP-seq
MIRT2276849	hsa-miR-4768-3p	CLIP-seq
MIRT2276858	hsa-miR-665	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFKB1	Unknown	15979574
RELA	Unknown	15979574
SP1	Activation	15979574
SP3	Activation	15979574

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0005201	Function	Extracellular matrix structural constituent	NAS	7680650
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0016266	Process	O-glycan processing	TAS
GO:0030277	Process	Maintenance of gastrointestinal epithelium	NAS	7680650
GO:0031012	Component	Extracellular matrix	IBA	21873635

Other IDs

• MIM: 158374
• HGNC: 7517
• e!Ensembl: ENSG00000184956

Protein

• UniProt ID: Q6W4X9
• Protein name: Mucin-6 (MUC-6) (Gastric mucin-6)
• Protein function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces a
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00094	VWD	45 → 193	von Willebrand factor type D domain	Family
  PF08742	C8	231 → 297	C8 domain	Domain
  PF01826	TIL	302 → 357	Trypsin Inhibitor like cysteine rich domain	Domain
  PF00094	VWD	397 → 550	von Willebrand factor type D domain	Family
  PF08742	C8	591 → 660	C8 domain	Domain
  PF01826	TIL	764 → 827	Trypsin Inhibitor like cysteine rich domain	Domain
  PF00094	VWD	868 → 1019	von Willebrand factor type D domain	Family
  PF08742	C8	1060 → 1127	C8 domain	Domain

• Sequence:

  MVQRWLLLSCCGALLSAGLANTSYTSPGLQRLKDSPQTAPDKGQCSTWGAGHFSTFDHHV
  YDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSISRIIVELGASVVTVSEAIISVKDIGV
  ISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFD
  GKVTNEFVSEEGKFLEPHKFAALQKLDDPGEICTFQDIPSTHVRQAQHARICTQLLTLVA
  PECSVSKEPFVLSCQADVAAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVG
  QCPANQVYQECGSACVKTCSNPQHSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCV
  LHGAMYAPGEVTIAACQTCRCTLGRWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCT
  YILLQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGEAKWL
  PYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDT
  TDDFTTSMGIAEGTASLFVDSWRAGNCPAALERETDPCSMSQLNKVCAETHCSMLLRTGT
  VFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNC
  TIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNCPDGTYLNQKGECVRKAQ
  CPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLASCQAPKTFKSCSQSSENK
  FGAACAPTCQMLATGVACVPTKCEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGA
  ELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCG
  VNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPG
  ALSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYV
  ASSELELVNSWKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLP
  YYEACVRDACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQD
  GHGEYQYTQEANCTWHYQPCLCPSQPQSVPGSNIEGCYNCSQDEYFDHEEGVCVPCMPPT
  TPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLT
  SSKPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTST
  AQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQP
  TRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSHPE
  TTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAP
  PITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAH
  TNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTHVPPFS
  TSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQ
  ALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSF
  STAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTH
  SPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTH
  TQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPY
  HTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSS
  TGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHS
  TPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSS
  RPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVG
  TSSSFVSAPVHSTTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPF
  TLSALLPISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRV
  PTSGFVSLTSGVTGIPTSPVTNLTTRHPGPTLSPTTRFLTSSLTAHGSTPASAPVSSLGT
  PTPTSPGVCSVREQQEEITFKGCMANVTVTRCEGACISAASFNIITQQVDARCSCCRPLH
  SYEQQLELPCPDPSTPGRRLVLTLQVFSHCVCSSVACGD

• Sequence length: 2439

Pathways

Reactome:

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Dectin-2 family
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	24816253

Unknown
Disease name	Disease term	dbSNP ID	References
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		24816253