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MT1A (metallothionein 1A)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4489
Gene nameGene Name - the full gene name approved by the HGNC.
Metallothionein 1A
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MT1A
SynonymsGene synonyms aliases
MT-1A, MT-IA, MT1, MT1S, MTC
ChromosomeChromosome number
16
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q13
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate meta
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT724135 hsa-miR-370-5p HITS-CLIP 19536157
MIRT724134 hsa-miR-4639-3p HITS-CLIP 19536157
MIRT724133 hsa-miR-130b-5p HITS-CLIP 19536157
MIRT724132 hsa-miR-3665 HITS-CLIP 19536157
MIRT724131 hsa-miR-657 HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16442532, 16778767
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm ISS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P04731
Protein name Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)
Protein function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00131 Metallothio
1 → 61
Metallothionein
 Domain
Sequence
Sequence length 61
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Mineral absorption   Metallothioneins bind metals
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 17418620
Nasopharyngeal carcinoma Nasopharyngeal carcinoma rs200046052 23209447
Unknown
Disease name Disease term dbSNP ID References
Arsenic encephalopathy Arsenic Encephalopathy 19953893
Urinary bladder cancer Malignant neoplasm of urinary bladder 16565513
Bladder neoplasm Bladder Neoplasm 16565513
Liver carcinoma Liver carcinoma 19363144, 17363595

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