MSR1 (macrophage scavenger receptor 1)

Gene

• Entrez ID: 4481
• Gene name: Macrophage scavenger receptor 1
• Gene symbol: MSR1
• Synonyms: CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2
• Chromosome: 8
• Chromosome location: 8p22
• Summary: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and ha

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs41341748	G>A,C	Uncertain-significance, conflicting-interpretations-of-pathogenicity, pathogenic	Coding sequence variant, stop gained, missense variant
rs387906645	G>C	Pathogenic	Coding sequence variant, missense variant
rs772978107	C>A,T	Likely-pathogenic	Splice acceptor variant
rs1554466908	C>G	Pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT723021	hsa-miR-7108-3p	HITS-CLIP	19536157
MIRT723020	hsa-miR-1249-3p	HITS-CLIP	19536157
MIRT723019	hsa-miR-9-5p	HITS-CLIP	19536157
MIRT723018	hsa-miR-323b-5p	HITS-CLIP	19536157
MIRT723017	hsa-miR-410-5p	HITS-CLIP	19536157
MIRT723016	hsa-miR-494-5p	HITS-CLIP	19536157
MIRT723015	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT723021	hsa-miR-7108-3p	HITS-CLIP	19536157
MIRT723020	hsa-miR-1249-3p	HITS-CLIP	19536157
MIRT723019	hsa-miR-9-5p	HITS-CLIP	19536157
MIRT723018	hsa-miR-323b-5p	HITS-CLIP	19536157
MIRT723017	hsa-miR-410-5p	HITS-CLIP	19536157
MIRT723016	hsa-miR-494-5p	HITS-CLIP	19536157
MIRT723015	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT1161779	hsa-miR-1265	CLIP-seq
MIRT1161780	hsa-miR-1273f	CLIP-seq
MIRT1161781	hsa-miR-143	CLIP-seq
MIRT1161782	hsa-miR-185	CLIP-seq
MIRT1161783	hsa-miR-2467-3p	CLIP-seq
MIRT1161784	hsa-miR-2964a-5p	CLIP-seq
MIRT1161785	hsa-miR-3165	CLIP-seq
MIRT1161786	hsa-miR-3175	CLIP-seq
MIRT1161787	hsa-miR-3605-5p	CLIP-seq
MIRT1161788	hsa-miR-4258	CLIP-seq
MIRT1161789	hsa-miR-4306	CLIP-seq
MIRT1161790	hsa-miR-433	CLIP-seq
MIRT1161791	hsa-miR-4449	CLIP-seq
MIRT1161792	hsa-miR-4512	CLIP-seq
MIRT1161793	hsa-miR-4644	CLIP-seq
MIRT1161794	hsa-miR-4698	CLIP-seq
MIRT1161795	hsa-miR-4708-5p	CLIP-seq
MIRT1161796	hsa-miR-4770	CLIP-seq
MIRT1161797	hsa-miR-630	CLIP-seq
MIRT1161798	hsa-miR-1270	CLIP-seq
MIRT1161799	hsa-miR-147	CLIP-seq
MIRT1161800	hsa-miR-338-5p	CLIP-seq
MIRT1161801	hsa-miR-3691-5p	CLIP-seq
MIRT1161802	hsa-miR-3911	CLIP-seq
MIRT1161803	hsa-miR-4531	CLIP-seq
MIRT1161804	hsa-miR-4683	CLIP-seq
MIRT1161805	hsa-miR-4752	CLIP-seq
MIRT1161806	hsa-miR-620	CLIP-seq
MIRT1161807	hsa-miR-644	CLIP-seq
MIRT2046411	hsa-miR-3613-3p	CLIP-seq
MIRT2275492	hsa-miR-1206	CLIP-seq
MIRT1161779	hsa-miR-1265	CLIP-seq
MIRT2275493	hsa-miR-1273e	CLIP-seq
MIRT1161780	hsa-miR-1273f	CLIP-seq
MIRT1161781	hsa-miR-143	CLIP-seq
MIRT2275494	hsa-miR-2054	CLIP-seq
MIRT1161783	hsa-miR-2467-3p	CLIP-seq
MIRT1161784	hsa-miR-2964a-5p	CLIP-seq
MIRT2275495	hsa-miR-302f	CLIP-seq
MIRT1161787	hsa-miR-3605-5p	CLIP-seq
MIRT2275496	hsa-miR-3618	CLIP-seq
MIRT1161791	hsa-miR-4449	CLIP-seq
MIRT1161795	hsa-miR-4708-5p	CLIP-seq
MIRT1161796	hsa-miR-4770	CLIP-seq
MIRT2275497	hsa-miR-579	CLIP-seq
MIRT2275498	hsa-miR-934	CLIP-seq
MIRT1161779	hsa-miR-1265	CLIP-seq
MIRT1161780	hsa-miR-1273f	CLIP-seq
MIRT1161781	hsa-miR-143	CLIP-seq
MIRT1161783	hsa-miR-2467-3p	CLIP-seq
MIRT1161784	hsa-miR-2964a-5p	CLIP-seq
MIRT1161787	hsa-miR-3605-5p	CLIP-seq
MIRT1161791	hsa-miR-4449	CLIP-seq
MIRT1161795	hsa-miR-4708-5p	CLIP-seq
MIRT1161796	hsa-miR-4770	CLIP-seq
MIRT2438811	hsa-miR-3908	CLIP-seq
MIRT2438812	hsa-miR-545	CLIP-seq
MIRT2438811	hsa-miR-3908	CLIP-seq
MIRT2438812	hsa-miR-545	CLIP-seq
MIRT2574509	hsa-miR-4481	CLIP-seq
MIRT2574510	hsa-miR-4663	CLIP-seq
MIRT2574511	hsa-miR-4728-3p	CLIP-seq
MIRT2574512	hsa-miR-4745-5p	CLIP-seq
MIRT2574513	hsa-miR-548c-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPA	Unknown	9743233
ETS2	Activation	8114743
JUN	Activation	8114743
JUN	Unknown	9743233
SPI1	Unknown	7777517

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IBA	21873635
GO:0001540	Function	Amyloid-beta binding	ISS
GO:0005044	Function	Scavenger receptor activity	TAS	11240025
GO:0005515	Function	Protein binding	IPI	17237231, 25416956, 25965346, 31515488, 32296183
GO:0005581	Component	Collagen trimer	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	8093617
GO:0006898	Process	Receptor-mediated endocytosis	ISS
GO:0006898	Process	Receptor-mediated endocytosis	NAS	2251254
GO:0006898	Process	Receptor-mediated endocytosis	TAS
GO:0006911	Process	Phagocytosis, engulfment	ISS
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0010629	Process	Negative regulation of gene expression	ISS
GO:0010744	Process	Positive regulation of macrophage derived foam cell differentiation	ISS	12376530
GO:0010886	Process	Positive regulation of cholesterol storage	IBA	21873635
GO:0010886	Process	Positive regulation of cholesterol storage	ISS
GO:0016021	Component	Integral component of membrane	NAS	2251254
GO:0030169	Function	Low-density lipoprotein particle binding	IBA	21873635
GO:0030169	Function	Low-density lipoprotein particle binding	ISS	12376530
GO:0030301	Process	Cholesterol transport	ISS	12376530
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0034362	Component	Low-density lipoprotein particle	IEA
GO:0034381	Process	Plasma lipoprotein particle clearance	IBA	21873635
GO:0034381	Process	Plasma lipoprotein particle clearance	ISS	12376530
GO:0038024	Function	Cargo receptor activity	ISS
GO:0097242	Process	Amyloid-beta clearance	IBA	21873635
GO:0097242	Process	Amyloid-beta clearance	ISS

Other IDs

• MIM: 153622
• HGNC: 7376
• e!Ensembl: ENSG00000038945

Protein

• UniProt ID: P21757
• Protein name: Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204)
• Protein function: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including m
• PDB: 7DPX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03523	Macscav_rec	121 → 169	Macrophage scavenger receptor	Family
  PF01391	Collagen	271 → 335	Collagen triple helix repeat (20 copies)	Repeat
  PF00530	SRCR	353 → 450	Scavenger receptor cysteine-rich domain	Domain

• Sequence:

  MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLV
  FAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSN
  MEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSL
  ISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEI
  KGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIG
  PPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHE
  GRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCF
  GRESSIEECKIRQWGTRACSHSEDAGVTCTL

• Sequence length: 451

Pathways

KEGG:

Phagosome

Reactome:

Scavenging by Class A Receptors

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Esophageal carcinoma	Esophageal carcinoma	rs121912967
Prostate cancer	Malignant neoplasm of prostate, Prostate cancer, familial, Familial prostate cancer	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16998812, 28031937, 12244320, 23141781

Unknown
Disease name	Disease term	dbSNP ID	References
Barrett epithelium	Barrett Epithelium
Barrett esophagus	Barrett Esophagus, NON RARE IN EUROPE: Barrett esophagus	rs41341748
Gastroesophageal reflux disease	Gastroesophageal reflux disease
Kidney failure	Kidney Failure, Chronic		19878707
Prostatic neoplasms	Prostatic Neoplasms		16998812
Ulcer of esophagus	Ulcer of esophagus