CAPN14 (calpain 14)

Gene

• Entrez ID: 440854
• Gene name: Calpain 14
• Gene symbol: CAPN14
• Synonyms: -
• Chromosome: 2
• Chromosome location: 2p23.1
• Summary: Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT861905	hsa-miR-1224-3p	CLIP-seq
MIRT861906	hsa-miR-1253	CLIP-seq
MIRT861907	hsa-miR-1295	CLIP-seq
MIRT861908	hsa-miR-3121-5p	CLIP-seq
MIRT861909	hsa-miR-3124-3p	CLIP-seq
MIRT861910	hsa-miR-3163	CLIP-seq
MIRT861911	hsa-miR-3194-5p	CLIP-seq
MIRT861912	hsa-miR-3198	CLIP-seq
MIRT861913	hsa-miR-3646	CLIP-seq
MIRT861914	hsa-miR-3673	CLIP-seq
MIRT861915	hsa-miR-3685	CLIP-seq
MIRT861916	hsa-miR-384	CLIP-seq
MIRT861917	hsa-miR-4251	CLIP-seq
MIRT861918	hsa-miR-4309	CLIP-seq
MIRT861919	hsa-miR-4690-3p	CLIP-seq
MIRT861920	hsa-miR-4717-5p	CLIP-seq
MIRT861921	hsa-miR-4760-5p	CLIP-seq
MIRT861922	hsa-miR-496	CLIP-seq
MIRT861923	hsa-miR-579	CLIP-seq
MIRT861924	hsa-miR-590-3p	CLIP-seq
MIRT2193358	hsa-miR-188-5p	CLIP-seq
MIRT2193359	hsa-miR-2355-3p	CLIP-seq
MIRT861908	hsa-miR-3121-5p	CLIP-seq
MIRT2193360	hsa-miR-3616-5p	CLIP-seq
MIRT2193361	hsa-miR-3647-5p	CLIP-seq
MIRT2193362	hsa-miR-3935	CLIP-seq
MIRT2193363	hsa-miR-4301	CLIP-seq
MIRT2193364	hsa-miR-4646-3p	CLIP-seq
MIRT2193365	hsa-miR-4762-3p	CLIP-seq
MIRT2193366	hsa-miR-4766-5p	CLIP-seq
MIRT2193367	hsa-miR-563	CLIP-seq
MIRT2193368	hsa-miR-573	CLIP-seq
MIRT2193369	hsa-miR-676	CLIP-seq
MIRT861912	hsa-miR-3198	CLIP-seq
MIRT861918	hsa-miR-4309	CLIP-seq
MIRT861921	hsa-miR-4760-5p	CLIP-seq
MIRT861922	hsa-miR-496	CLIP-seq
MIRT861924	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA	21873635
GO:0005509	Function	Calcium ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006508	Process	Proteolysis	IBA	21873635

Other IDs

• MIM: 610229
• HGNC: 16664
• e!Ensembl: ENSG00000214711

Protein

• UniProt ID: A8MX76
• Protein name: Calpain-14 (EC 3.4.22.-) (Calcium-activated neutral proteinase 14) (CANP 14)
• Protein function: Calcium-regulated non-lysosomal thiol-protease.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00648	Peptidase_C2	44 → 334	Calpain family cysteine protease	Family
  PF01067	Calpain_III	355 → 491	Calpain large subunit, domain III	Domain

• Sequence:

  MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS
  LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV
  VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK
  AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH
  SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS
  PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR
  STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI
  GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA
  HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN
  LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD
  RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF
  QNLTQDGKGIYLQKPEWMMMALYS

• Sequence length: 684

Pathways

Reactome:

Degradation of the extracellular matrix

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Endometriosis	Endometriosis	rs1800629, rs1143634	28333195
Eosinophilia	Eosinophilic esophagitis		25017104, 25407941