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ASMT (acetylserotonin O-methyltransferase)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
438
Gene nameGene Name - the full gene name approved by the HGNC.
Acetylserotonin O-methyltransferase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ASMT
SynonymsGene synonyms aliases
ASMTY, HIOMT, HIOMTY
ChromosomeChromosome number
X|Y
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
X;Y
SummarySummary of gene provided in NCBI Entrez Gene.
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abund
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT2176846 hsa-miR-4795-3p CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005829 Component Cytosol TAS
GO:0006412 Process Translation TAS 8397829
GO:0008171 Function O-methyltransferase activity IBA 21873635
GO:0008172 Function S-methyltransferase activity TAS
GO:0008757 Function S-adenosylmethionine-dependent methyltransferase activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P46597
Protein name Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT)
Protein function [Isoform 1]: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). ; [Isoform 2]: Does not show Acetylserotonin O-methyltransferase activity.
PDB 4A6D , 4A6E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16864 Dimerisation2
11 → 100
Dimerisation domain
 Domain
PF00891 Methyltransf_2
117 → 327
O-methyltransferase domain
 Domain
Sequence
Sequence length 345
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Tryptophan metabolism
Metabolic pathways 		  Serotonin and melatonin biosynthesis
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Autism Autistic Disorder rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634 17505466
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 22694957
Hepatolenticular degeneration Hepatolenticular Degeneration, Hepatic Form of Wilson Disease 23519153
Mental depression Mental Depression, Depressive disorder rs587778876, rs587778877 22694957, 24881886

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