MRC1 (mannose receptor C-type 1)

Gene

• Entrez ID: 4360
• Gene name: Mannose receptor C-type 1
• Gene symbol: MRC1
• Synonyms: CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR
• Chromosome: 10
• Chromosome location: 10p12.33
• Summary: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs606231248	G>A	Risk-factor	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT442609	hsa-miR-4480	PAR-CLIP	22100165
MIRT442608	hsa-miR-4448	PAR-CLIP	22100165
MIRT442609	hsa-miR-4480	PAR-CLIP	22100165
MIRT442608	hsa-miR-4448	PAR-CLIP	22100165
MIRT1157619	hsa-miR-105	CLIP-seq
MIRT1157620	hsa-miR-1305	CLIP-seq
MIRT1157621	hsa-miR-145	CLIP-seq
MIRT1157622	hsa-miR-3121-3p	CLIP-seq
MIRT1157623	hsa-miR-3145-3p	CLIP-seq
MIRT1157624	hsa-miR-3671	CLIP-seq
MIRT1157625	hsa-miR-3684	CLIP-seq
MIRT1157626	hsa-miR-409-3p	CLIP-seq
MIRT1157627	hsa-miR-491-3p	CLIP-seq
MIRT1157628	hsa-miR-511	CLIP-seq
MIRT1157629	hsa-miR-570	CLIP-seq
MIRT1157630	hsa-miR-607	CLIP-seq
MIRT1157631	hsa-miR-944	CLIP-seq
MIRT2274291	hsa-miR-3130-3p	CLIP-seq
MIRT2274292	hsa-miR-3182	CLIP-seq
MIRT2274293	hsa-miR-4659a-3p	CLIP-seq
MIRT2274294	hsa-miR-4659b-3p	CLIP-seq
MIRT2274295	hsa-miR-4793-3p	CLIP-seq
MIRT2274296	hsa-miR-544	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	11222859
GO:0005537	Function	Mannose binding	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	20035344
GO:0005887	Component	Integral component of plasma membrane	TAS	1294118
GO:0006898	Process	Receptor-mediated endocytosis	IBA	21873635
GO:0006898	Process	Receptor-mediated endocytosis	IDA	20035344
GO:0009986	Component	Cell surface	IEA
GO:0010008	Component	Endosome membrane	IDA	20035344
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0038024	Function	Cargo receptor activity	IDA	20035344
GO:0046718	Process	Viral entry into host cell	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071346	Process	Cellular response to interferon-gamma	IEA
GO:0071353	Process	Cellular response to interleukin-4	IEA

Other IDs

• MIM: 153618
• HGNC: 7228
• e!Ensembl: ENSG00000260314

Protein

• UniProt ID: P22897
• Protein name: Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)
• Protein function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial i
• PDB: 1EGG, 1EGI, 5XTS, 5XTW, 6INN, 6INO, 6INU, 6INV, 6IOE, 7JUB, 7JUC, 7JUD, 7JUE, 7JUF, 7JUG, 7JUH, 7L61, 7L62, 7L63, 7L64, 7L65, 7L66, 7L67, 7L68
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00652	Ricin_B_lectin	23 → 118	Ricin-type beta-trefoil lectin domain	Domain
  PF00040	fn2	168 → 209	Fibronectin type II domain	Domain
  PF00059	Lectin_C	236 → 342	Lectin C-type domain	Domain
  PF00059	Lectin_C	380 → 488	Lectin C-type domain	Domain
  PF00059	Lectin_C	521 → 627	Lectin C-type domain	Domain
  PF00059	Lectin_C	669 → 779	Lectin C-type domain	Domain
  PF00059	Lectin_C	817 → 924	Lectin C-type domain	Domain
  PF00059	Lectin_C	966 → 1081	Lectin C-type domain	Domain
  PF00059	Lectin_C	1112 → 1214	Lectin C-type domain	Domain
  PF00059	Lectin_C	1252 → 1357	Lectin C-type domain	Domain

• Sequence:

  MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
  VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG
  NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA
  DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW
  HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
  LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT
  HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND
  ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW
  PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT
  TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
  VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF
  KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG
  SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ
  KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS
  ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
  TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF
  GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF
  LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ
  TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA
  FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
  TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS
  LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
  NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD
  PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD
  MKDLVGNIEQNEHSVI

• Sequence length: 1456

Pathways

KEGG:

Phagosome
Tuberculosis

Reactome:

Cross-presentation of soluble exogenous antigens (endosomes)
Modulation by Mtb of host immune system

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404
Hyperinsulinism	Hyperinsulinism	rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180	29035695
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	29035695

Unknown
Disease name	Disease term	dbSNP ID	References
Compensatory hyperinsulinemia	Compensatory Hyperinsulinemia		29035695
Endogenous hyperinsulinism	Endogenous Hyperinsulinism		29035695
Exogenous hyperinsulinism	Exogenous Hyperinsulinism		29035695