MPP1 (MAGUK p55 scaffold protein 1)

Gene

• Entrez ID: 4354
• Gene name: MAGUK p55 scaffold protein 1
• Gene symbol: MPP1
• Synonyms: AAG12, DXS552E, EMP55, MRG1, PEMP
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensiv

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046417	hsa-miR-15b-5p	CLASH	23622248
MIRT727164	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727163	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727162	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1156267	hsa-miR-1283	CLIP-seq
MIRT1156268	hsa-miR-1323	CLIP-seq
MIRT1156269	hsa-miR-2278	CLIP-seq
MIRT1156270	hsa-miR-3166	CLIP-seq
MIRT1156271	hsa-miR-361-3p	CLIP-seq
MIRT1156272	hsa-miR-3679-3p	CLIP-seq
MIRT1156273	hsa-miR-4446-5p	CLIP-seq
MIRT1156274	hsa-miR-4487	CLIP-seq
MIRT1156275	hsa-miR-4755-5p	CLIP-seq
MIRT1156276	hsa-miR-493	CLIP-seq
MIRT1156277	hsa-miR-548o	CLIP-seq
MIRT1156278	hsa-miR-642b	CLIP-seq
MIRT1156279	hsa-miR-671-5p	CLIP-seq
MIRT1156268	hsa-miR-1323	CLIP-seq
MIRT1156274	hsa-miR-4487	CLIP-seq
MIRT1156277	hsa-miR-548o	CLIP-seq
MIRT1156278	hsa-miR-642b	CLIP-seq
MIRT1156279	hsa-miR-671-5p	CLIP-seq
MIRT2044679	hsa-miR-1256	CLIP-seq
MIRT2044680	hsa-miR-1271	CLIP-seq
MIRT2044681	hsa-miR-182	CLIP-seq
MIRT2044682	hsa-miR-25	CLIP-seq
MIRT2044683	hsa-miR-32	CLIP-seq
MIRT2044684	hsa-miR-363	CLIP-seq
MIRT2044685	hsa-miR-367	CLIP-seq
MIRT2044686	hsa-miR-4642	CLIP-seq
MIRT2044687	hsa-miR-616	CLIP-seq
MIRT2044688	hsa-miR-92a	CLIP-seq
MIRT2044689	hsa-miR-92b	CLIP-seq
MIRT2044690	hsa-miR-96	CLIP-seq
MIRT2273959	hsa-miR-105	CLIP-seq
MIRT2273960	hsa-miR-1287	CLIP-seq
MIRT1156268	hsa-miR-1323	CLIP-seq
MIRT2273961	hsa-miR-185	CLIP-seq
MIRT2273962	hsa-miR-3135b	CLIP-seq
MIRT2273963	hsa-miR-3184	CLIP-seq
MIRT2273964	hsa-miR-423-5p	CLIP-seq
MIRT2273965	hsa-miR-4306	CLIP-seq
MIRT1156274	hsa-miR-4487	CLIP-seq
MIRT2273966	hsa-miR-4644	CLIP-seq
MIRT2273967	hsa-miR-4688	CLIP-seq
MIRT1156277	hsa-miR-548o	CLIP-seq
MIRT1156278	hsa-miR-642b	CLIP-seq
MIRT1156279	hsa-miR-671-5p	CLIP-seq
MIRT1156268	hsa-miR-1323	CLIP-seq
MIRT1156277	hsa-miR-548o	CLIP-seq
MIRT1156278	hsa-miR-642b	CLIP-seq
MIRT2273959	hsa-miR-105	CLIP-seq
MIRT2273960	hsa-miR-1287	CLIP-seq
MIRT1156268	hsa-miR-1323	CLIP-seq
MIRT2572791	hsa-miR-146b-3p	CLIP-seq
MIRT2273961	hsa-miR-185	CLIP-seq
MIRT2572792	hsa-miR-193a-3p	CLIP-seq
MIRT2572793	hsa-miR-193b	CLIP-seq
MIRT2572794	hsa-miR-22	CLIP-seq
MIRT2572795	hsa-miR-2467-3p	CLIP-seq
MIRT2572796	hsa-miR-3064-5p	CLIP-seq
MIRT2273962	hsa-miR-3135b	CLIP-seq
MIRT2572797	hsa-miR-3158-5p	CLIP-seq
MIRT2572798	hsa-miR-3656	CLIP-seq
MIRT2572799	hsa-miR-3678-3p	CLIP-seq
MIRT2572800	hsa-miR-4259	CLIP-seq
MIRT2273965	hsa-miR-4306	CLIP-seq
MIRT2572801	hsa-miR-4422	CLIP-seq
MIRT1156274	hsa-miR-4487	CLIP-seq
MIRT2273966	hsa-miR-4644	CLIP-seq
MIRT2572802	hsa-miR-4680-3p	CLIP-seq
MIRT2572803	hsa-miR-4708-3p	CLIP-seq
MIRT2572804	hsa-miR-4715-5p	CLIP-seq
MIRT2572805	hsa-miR-511	CLIP-seq
MIRT1156277	hsa-miR-548o	CLIP-seq
MIRT1156278	hsa-miR-642b	CLIP-seq
MIRT2572806	hsa-miR-651	CLIP-seq
MIRT2572807	hsa-miR-892b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004385	Function	Guanylate kinase activity	TAS	1310897
GO:0005515	Function	Protein binding	IPI	17584769, 19144871, 21903422, 25416956, 26871637, 29146910, 32296183, 32814053
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS	1713685
GO:0007165	Process	Signal transduction	TAS	1713685
GO:0016020	Component	Membrane	HDA	19946888
GO:0030863	Component	Cortical cytoskeleton	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0034451	Component	Centriolar satellite	IDA
GO:0046037	Process	GMP metabolic process	IEA
GO:0046710	Process	GDP metabolic process	IEA
GO:0090022	Process	Regulation of neutrophil chemotaxis	ISS

Other IDs

• MIM: 305360
• HGNC: 7219
• e!Ensembl: ENSG00000130830

Protein

• UniProt ID: Q00013
• Protein name: 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)
• Protein function: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
• PDB: 2EJY, 2EV8, 3NEY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	71 → 149	PDZ domain	Domain
  PF00018	SH3_1	164 → 220	SH3 domain	Domain
  PF00625	Guanylate_kin	281 → 453	Guanylate kinase	Domain

• Sequence:

  MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQ
  VKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEI
  NGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCK
  EAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAP
  SCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKN
  ALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFG
  TKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSE
  AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY

• Sequence length: 466

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	21552421
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	21552421
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	21552421

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		21552421