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MMP16 (matrix metallopeptidase 16)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4325
Gene nameGene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 16
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MMP16
SynonymsGene synonyms aliases
C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004887 hsa-miR-146b-5p U138 19265686
MIRT004887 hsa-miR-146b-5p U138 19265686
MIRT004887 hsa-miR-146b-5p U138 19265686
MIRT004887 hsa-miR-146b-5p U138 19265686
MIRT004978 hsa-miR-31-5p Luciferase reporter assay, qRT-PCR, Western blot 19524507
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development IBA 21873635
GO:0001958 Process Endochondral ossification IEA
GO:0004222 Function Metalloendopeptidase activity IBA 21873635
GO:0004222 Function Metalloendopeptidase activity IDA 27229514
GO:0005796 Component Golgi lumen TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P51512
Protein name Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
Protein function Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also coll
PDB 1RM8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1
38 96
Putative peptidoglycan binding domain
Domain
PF00413 Peptidase_M10
126 291
Matrixin
Domain
PF00045 Hemopexin
349 390
Hemopexin
Repeat
PF00045 Hemopexin
392 436
Hemopexin
Repeat
PF00045 Hemopexin
439 485
Hemopexin
Repeat
PF00045 Hemopexin
487 532
Hemopexin
Repeat
PF11857 DUF3377
537 607
Domain of unknown function (DUF3377)
Family
Sequence
Sequence length 607
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Parathyroid hormone synthesis, secretion and action
MicroRNAs in cancer
  Activation of Matrix Metalloproteinases
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 28540026, 21791550, 30285260, 29483656, 28991256, 26198764
Unknown
Disease name Disease term dbSNP ID References
Development disorder Child Development Disorders, Pervasive 28540026

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