MMP8 (matrix metallopeptidase 8)

Gene

• Entrez ID: 4317
• Gene name: Matrix metallopeptidase 8
• Gene symbol: MMP8
• Synonyms: CLG1, HNC, MMP-8, PMNL-CL
• Chromosome: 11
• Chromosome location: 11q22.2
• Summary: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028875	hsa-miR-26b-5p	Microarray	19088304
MIRT1153518	hsa-miR-1237	CLIP-seq
MIRT1153519	hsa-miR-1248	CLIP-seq
MIRT1153520	hsa-miR-1343	CLIP-seq
MIRT1153521	hsa-miR-3124-3p	CLIP-seq
MIRT1153522	hsa-miR-3919	CLIP-seq
MIRT1153523	hsa-miR-421	CLIP-seq
MIRT1153524	hsa-miR-4266	CLIP-seq
MIRT1153525	hsa-miR-4646-5p	CLIP-seq
MIRT1153526	hsa-miR-4695-5p	CLIP-seq
MIRT1153527	hsa-miR-4709-5p	CLIP-seq
MIRT1153528	hsa-miR-4747-5p	CLIP-seq
MIRT1153529	hsa-miR-4753-3p	CLIP-seq
MIRT1153530	hsa-miR-4779	CLIP-seq
MIRT1153531	hsa-miR-604	CLIP-seq
MIRT1153532	hsa-miR-626	CLIP-seq
MIRT1153533	hsa-miR-647	CLIP-seq
MIRT1153534	hsa-miR-942	CLIP-seq
MIRT2043931	hsa-miR-3152-5p	CLIP-seq
MIRT2043932	hsa-miR-3667-3p	CLIP-seq
MIRT2043933	hsa-miR-500a	CLIP-seq
MIRT2043934	hsa-miR-502-5p	CLIP-seq
MIRT2273327	hsa-miR-204	CLIP-seq
MIRT2273328	hsa-miR-211	CLIP-seq
MIRT1153523	hsa-miR-421	CLIP-seq
MIRT2273329	hsa-miR-4648	CLIP-seq
MIRT2273330	hsa-miR-4654	CLIP-seq
MIRT2273331	hsa-miR-4755-5p	CLIP-seq
MIRT2273332	hsa-miR-4766-5p	CLIP-seq
MIRT2273333	hsa-miR-4769-5p	CLIP-seq
MIRT2273334	hsa-miR-543	CLIP-seq
MIRT2273335	hsa-miR-623	CLIP-seq
MIRT2273336	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IMP	25049354
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	IDA	2164002, 16192646
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	2164002, 24784232
GO:0006508	Process	Proteolysis	IDA	2164002
GO:0008233	Function	Peptidase activity	IDA	23845380
GO:0008270	Function	Zinc ion binding	TAS	2164002
GO:0010628	Process	Positive regulation of gene expression	ISS	25049354
GO:0010629	Process	Negative regulation of gene expression	ISS	25049354
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0030574	Process	Collagen catabolic process	IBA	21873635
GO:0030574	Process	Collagen catabolic process	TAS
GO:0032693	Process	Negative regulation of interleukin-10 production	ISS	25049354
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS	25049354
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS	25049354
GO:0035580	Component	Specific granule lumen	TAS
GO:0035987	Process	Endodermal cell differentiation	IEP	23154389
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043388	Process	Positive regulation of DNA binding	ISS	25049354
GO:0043410	Process	Positive regulation of MAPK cascade	ISS	25049354
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	ISS	25049354
GO:0046330	Process	Positive regulation of JNK cascade	ISS	25049354
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28344315
GO:0150077	Process	Regulation of neuroinflammatory response	TAS	25049354
GO:0150078	Process	Positive regulation of neuroinflammatory response	ISS	25049354
GO:1901224	Process	Positive regulation of NIK/NF-kappaB signaling	ISS	25049354
GO:1903428	Process	Positive regulation of reactive oxygen species biosynthetic process	ISS	25049354
GO:1903978	Process	Regulation of microglial cell activation	TAS	25049354
GO:1903980	Process	Positive regulation of microglial cell activation	ISS	25049354
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 120355
• HGNC: 7175
• e!Ensembl: ENSG00000118113

Protein

• UniProt ID: P22894
• Protein name: Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
• Protein function: Can degrade fibrillar type I, II, and III collagens.
• PDB: 1A85, 1A86, 1BZS, 1I73, 1I76, 1JAN, 1JAO, 1JAP, 1JAQ, 1JH1, 1JJ9, 1KBC, 1MMB, 1MNC, 1ZP5, 1ZS0, 1ZVX, 2OY2, 2OY4, 3DNG, 3DPE, 3DPF, 3TT4, 4QKZ, 5H8X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01471	PG_binding_1	26 → 86	Putative peptidoglycan binding domain	Domain
  PF00413	Peptidase_M10	107 → 262	Matrixin	Domain
  PF00045	Hemopexin	285 → 327	Hemopexin	Repeat
  PF00045	Hemopexin	329 → 372	Hemopexin	Repeat
  PF00045	Hemopexin	377 → 422	Hemopexin	Repeat

• Sequence:

  MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
  EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
  TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
  AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
  FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
  RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
  YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
  ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

• Sequence length: 467

Pathways

Reactome:

Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Epilepsy	Epilepsy, Generalized	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	25087078
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	19330028

Unknown
Disease name	Disease term	dbSNP ID	References
Lung diseases	Lung diseases		21602193
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	23794217