MLLT3 (MLLT3 super elongation complex subunit)

Gene

• Entrez ID: 4300
• Gene name: MLLT3 super elongation complex subunit
• Gene symbol: MLLT3
• Synonyms: AF9, YEATS3
• Chromosome: 9
• Chromosome location: 9p21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022911	hsa-miR-124-3p	Microarray	18668037
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT535872	hsa-miR-5692b	PAR-CLIP	20371350
MIRT535871	hsa-miR-5692c	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508973	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT508972	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT535872	hsa-miR-5692b	PAR-CLIP	22012620
MIRT535871	hsa-miR-5692c	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT508973	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT508972	hsa-miR-223-5p	PAR-CLIP	22012620
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT508969	hsa-miR-3924	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508973	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT508972	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508969	hsa-miR-3924	PAR-CLIP	23446348
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT535872	hsa-miR-5692b	PAR-CLIP	20371350
MIRT535871	hsa-miR-5692c	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508973	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT508972	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT535872	hsa-miR-5692b	PAR-CLIP	22012620
MIRT535871	hsa-miR-5692c	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT508973	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT508972	hsa-miR-223-5p	PAR-CLIP	22012620
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT508969	hsa-miR-3924	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508973	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT508972	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508969	hsa-miR-3924	PAR-CLIP	23446348
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1152149	hsa-miR-1237	CLIP-seq
MIRT1152150	hsa-miR-1248	CLIP-seq
MIRT1152151	hsa-miR-1283	CLIP-seq
MIRT1152152	hsa-miR-1299	CLIP-seq
MIRT1152153	hsa-miR-31	CLIP-seq
MIRT1152154	hsa-miR-3121-3p	CLIP-seq
MIRT1152155	hsa-miR-33a	CLIP-seq
MIRT1152156	hsa-miR-33b	CLIP-seq
MIRT1152157	hsa-miR-3653	CLIP-seq
MIRT1152158	hsa-miR-3658	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT1152160	hsa-miR-3974	CLIP-seq
MIRT1152161	hsa-miR-4328	CLIP-seq
MIRT1152162	hsa-miR-450b-3p	CLIP-seq
MIRT1152163	hsa-miR-4700-3p	CLIP-seq
MIRT1152164	hsa-miR-4709-5p	CLIP-seq
MIRT1152165	hsa-miR-4782-5p	CLIP-seq
MIRT1152166	hsa-miR-4796-3p	CLIP-seq
MIRT1152167	hsa-miR-488	CLIP-seq
MIRT1152168	hsa-miR-500a	CLIP-seq
MIRT1152169	hsa-miR-516b	CLIP-seq
MIRT1152170	hsa-miR-564	CLIP-seq
MIRT1152171	hsa-miR-570	CLIP-seq
MIRT1152172	hsa-miR-769-3p	CLIP-seq
MIRT1152173	hsa-miR-875-3p	CLIP-seq
MIRT2043341	hsa-miR-1253	CLIP-seq
MIRT2043342	hsa-miR-4426	CLIP-seq
MIRT2043343	hsa-miR-4434	CLIP-seq
MIRT2043344	hsa-miR-4516	CLIP-seq
MIRT2043345	hsa-miR-4531	CLIP-seq
MIRT2043346	hsa-miR-4647	CLIP-seq
MIRT2043347	hsa-miR-4662b	CLIP-seq
MIRT2043348	hsa-miR-4802-5p	CLIP-seq
MIRT2043349	hsa-miR-5095	CLIP-seq
MIRT2043350	hsa-miR-552	CLIP-seq
MIRT2043351	hsa-miR-603	CLIP-seq
MIRT1152173	hsa-miR-875-3p	CLIP-seq
MIRT2272725	hsa-miR-4436a	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT2571646	hsa-miR-1276	CLIP-seq
MIRT2571647	hsa-miR-1287	CLIP-seq
MIRT2571648	hsa-miR-2277-3p	CLIP-seq
MIRT2571649	hsa-miR-3065-5p	CLIP-seq
MIRT1152153	hsa-miR-31	CLIP-seq
MIRT2571650	hsa-miR-3135b	CLIP-seq
MIRT2571651	hsa-miR-3148	CLIP-seq
MIRT2571652	hsa-miR-3165	CLIP-seq
MIRT1152155	hsa-miR-33a	CLIP-seq
MIRT1152156	hsa-miR-33b	CLIP-seq
MIRT2571653	hsa-miR-374a	CLIP-seq
MIRT2571654	hsa-miR-374b	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT1152160	hsa-miR-3974	CLIP-seq
MIRT2571655	hsa-miR-3978	CLIP-seq
MIRT2571656	hsa-miR-409-3p	CLIP-seq
MIRT2571657	hsa-miR-4320	CLIP-seq
MIRT2571658	hsa-miR-4424	CLIP-seq
MIRT2272725	hsa-miR-4436a	CLIP-seq
MIRT2571659	hsa-miR-4502	CLIP-seq
MIRT1152162	hsa-miR-450b-3p	CLIP-seq
MIRT2571660	hsa-miR-4731-3p	CLIP-seq
MIRT1152166	hsa-miR-4796-3p	CLIP-seq
MIRT2571661	hsa-miR-4801	CLIP-seq
MIRT1152167	hsa-miR-488	CLIP-seq
MIRT2043349	hsa-miR-5095	CLIP-seq
MIRT2571662	hsa-miR-548n	CLIP-seq
MIRT2571663	hsa-miR-548t	CLIP-seq
MIRT2043350	hsa-miR-552	CLIP-seq
MIRT1152170	hsa-miR-564	CLIP-seq
MIRT2571664	hsa-miR-654-3p	CLIP-seq
MIRT1152172	hsa-miR-769-3p	CLIP-seq
MIRT2571665	hsa-miR-890	CLIP-seq
MIRT2571666	hsa-miR-891a	CLIP-seq
MIRT2571646	hsa-miR-1276	CLIP-seq
MIRT2571647	hsa-miR-1287	CLIP-seq
MIRT2571648	hsa-miR-2277-3p	CLIP-seq
MIRT2571649	hsa-miR-3065-5p	CLIP-seq
MIRT1152153	hsa-miR-31	CLIP-seq
MIRT2571650	hsa-miR-3135b	CLIP-seq
MIRT2571651	hsa-miR-3148	CLIP-seq
MIRT2571652	hsa-miR-3165	CLIP-seq
MIRT1152155	hsa-miR-33a	CLIP-seq
MIRT1152156	hsa-miR-33b	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT1152160	hsa-miR-3974	CLIP-seq
MIRT2571655	hsa-miR-3978	CLIP-seq
MIRT2571656	hsa-miR-409-3p	CLIP-seq
MIRT2571657	hsa-miR-4320	CLIP-seq
MIRT2571658	hsa-miR-4424	CLIP-seq
MIRT2272725	hsa-miR-4436a	CLIP-seq
MIRT1152162	hsa-miR-450b-3p	CLIP-seq
MIRT2571660	hsa-miR-4731-3p	CLIP-seq
MIRT1152166	hsa-miR-4796-3p	CLIP-seq
MIRT2571661	hsa-miR-4801	CLIP-seq
MIRT1152167	hsa-miR-488	CLIP-seq
MIRT2043349	hsa-miR-5095	CLIP-seq
MIRT2571662	hsa-miR-548n	CLIP-seq
MIRT2571663	hsa-miR-548t	CLIP-seq
MIRT2043350	hsa-miR-552	CLIP-seq
MIRT1152170	hsa-miR-564	CLIP-seq
MIRT1152172	hsa-miR-769-3p	CLIP-seq
MIRT2571665	hsa-miR-890	CLIP-seq
MIRT2571666	hsa-miR-891a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	25417107, 27105114
GO:0005515	Function	Protein binding	IPI	16189514, 20153263, 20203130, 21729782, 23145062, 23260655, 26496610, 28514442, 32296183
GO:0005634	Component	Nucleus	TAS	8506309
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006366	Process	Transcription by RNA polymerase II	TAS
GO:0006368	Process	Transcription elongation from RNA polymerase II promoter	TAS
GO:0007379	Process	Segment specification	IEA
GO:0008023	Component	Transcription elongation factor complex	IDA	22195968, 25417107, 27105114
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0042393	Function	Histone binding	IDA	27105114, 27545619
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	25417107, 27105114, 31776511
GO:0060218	Process	Hematopoietic stem cell differentiation	IDA	31776511
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070577	Function	Lysine-acetylated histone binding	IDA	25417107
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	19591803
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	19591803
GO:0140030	Function	Modification-dependent protein binding	IDA	27105114, 27545619
GO:1902275	Process	Regulation of chromatin organization	IMP	31776511
GO:2000035	Process	Regulation of stem cell division	IDA	31776511
GO:2000096	Process	Positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI	19591803

Other IDs

• MIM: 159558
• HGNC: 7136
• e!Ensembl: ENSG00000171843

Protein

• UniProt ID: P42568
• Protein name: Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
• Protein function: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:201
• PDB: 2LM0, 2MV7, 2N4Q, 2NDF, 2NDG, 4TMP, 5HJB, 5HJD, 5YYF, 6B7G, 6L5Z, 6LS6, 6MIL, 6MIM, 7EIC, 7EID, 7VKG, 7VKH, 8PJ7, 8TLV, 8TLW, 8TLX, 9ARO, 9ARR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03366	YEATS	29 → 110	YEATS family	Domain
  PF17793	AHD	503 → 563	ANC1 homology domain (AHD)	Domain

• Sequence:

  MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP
  RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE
  KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
  SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK
  PLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
  SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
  PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD
  EVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILE
  VKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITN
  TTFDFDLCSLDKTTVRKLQSYLETSGTS

• Sequence length: 568

Pathways

KEGG:

Viral life cycle - HIV-1
Transcriptional misregulation in cancer

Reactome:

Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	26083242

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20874815
Myeloid leukemia with t(9;11)(p22;q23)	Acute myeloid leukemia with t(9;11)(p22;q23)