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MGMT (O-6-methylguanine-DNA methyltransferase)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4255
Gene nameGene Name - the full gene name approved by the HGNC.
O-6-methylguanine-DNA methyltransferase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MGMT
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.3
SummarySummary of gene provided in NCBI Entrez Gene.
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT006937 hsa-miR-181d-5p Luciferase reporter assay, qRT-PCR, Western blot 22570426
MIRT006937 hsa-miR-181d-5p Luciferase reporter assay, qRT-PCR, Western blot 22570426
MIRT438835 hsa-miR-661 Luciferase reporter assay 23340988
MIRT438835 hsa-miR-661 Luciferase reporter assay 23340988
MIRT438833 hsa-miR-370-3p Luciferase reporter assay 23340988
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
DNMT1 Unknown 18555750
EP300 Unknown 22675172
HDAC1 Unknown 18555750
JUN Unknown 9731508
MBD1 Repression 15657354
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003908 Function Methylated-DNA-[protein]-cysteine S-methyltransferase activity IBA 21873635
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P16455
Protein name Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)
Protein function Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue
PDB 1EH6 , 1EH7 , 1EH8 , 1QNT , 1T38 , 1T39 , 1YFH , 8RGG , 8RGH , 8RTY , 8RU2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02870 Methyltransf_1N
6 → 90
6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
 Domain
PF01035 DNA_binding_1
93 → 174
6-O-methylguanine DNA methyltransferase, DNA binding domain
 Domain
Sequence
Sequence length 207
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    MGMT-mediated DNA damage reversal
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Carcinoma of the head and neck Squamous cell carcinoma of the head and neck rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001, rs786201838, rs587782144, rs866775781, rs730882008, rs1567549584, rs1597371666, rs1597365075 24991542
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25574825
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 25520135
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 22162573, 20131314
Unknown
Disease name Disease term dbSNP ID References
Anorexia Anorexia Nervosa 31308545
Atypical mole melanoma syndrome Familial Atypical Mole Melanoma Syndrome 24801985
Brain neoplasms Brain Neoplasms, Malignant neoplasm of brain, Benign neoplasm of brain, unspecified, Brain Tumor, Primary, Recurrent Brain Neoplasm, Primary malignant neoplasm of brain rs1800720, rs587781720 20131314
Mammary neoplasms Mammary Neoplasms

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