Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
4249 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
MGAT5 |
SynonymsGene synonyms aliases
|
GNT-V, GNT-VA, MGAT5A, glcNAc-T V |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2q21.2-q21.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It i |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
ETS1 |
Unknown |
10438459 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q09328 |
Protein name |
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V) [Clea |
Protein function |
Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, comp |
PDB |
5ZIB
,
5ZIC
,
6YJQ
,
6YJR
,
6YJS
,
6YJT
,
6YJU
,
6YJV
,
7YYI
,
7Z07
,
7Z08
,
7Z0B
,
8CE3
,
9F5H
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF15027 |
DUF4525 |
3 → 138 |
Domain of unknown function (DUF4525) |
Family |
PF15024 |
Glyco_transf_18 |
172 → 726 |
Glycosyltransferase family 18 |
Family |
|
Sequence |
|
Sequence length |
741 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Multiple sclerosis |
Multiple Sclerosis |
rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544 |
20117844 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
B-cell lymphoma |
Marginal Zone B-Cell Lymphoma |
|
31407831 |
Lymphocytic leukemia |
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma |
|
31407831 |
Lupus erythematosus |
Lupus Erythematosus, Systemic |
|
28714469, 31407831 |
|