GediPNet logo

MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4249
Gene nameGene Name - the full gene name approved by the HGNC.
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MGAT5
SynonymsGene synonyms aliases
GNT-V, GNT-VA, MGAT5A, glcNAc-T V
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q21.2-q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It i
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047339 hsa-miR-181a-5p CLASH 23622248
MIRT039157 hsa-miR-769-5p CLASH 23622248
MIRT037984 hsa-miR-502-3p CLASH 23622248
MIRT712416 hsa-miR-4695-5p HITS-CLIP 19536157
MIRT712415 hsa-miR-4459 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
ETS1 Unknown 10438459
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane ISS
GO:0000139 Component Golgi membrane TAS
GO:0004864 Function Protein phosphatase inhibitor activity IDA 24846175
GO:0005794 Component Golgi apparatus IBA 21873635
GO:0006487 Process Protein N-linked glycosylation IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q09328
Protein name Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V) [Clea
Protein function Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, comp
PDB 5ZIB , 5ZIC , 6YJQ , 6YJR , 6YJS , 6YJT , 6YJU , 6YJV , 7YYI , 7Z07 , 7Z08 , 7Z0B , 8CE3 , 9F5H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15027 DUF4525
3 138
Domain of unknown function (DUF4525)
Family
PF15024 Glyco_transf_18
172 726
Glycosyltransferase family 18
Family
Sequence
Sequence length 741
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  N-Glycan biosynthesis
Metabolic pathways
  N-Glycan antennae elongation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Multiple sclerosis Multiple Sclerosis rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544 20117844
Unknown
Disease name Disease term dbSNP ID References
B-cell lymphoma Marginal Zone B-Cell Lymphoma 31407831
Lymphocytic leukemia Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 31407831
Lupus erythematosus Lupus Erythematosus, Systemic 28714469, 31407831

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412